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Displaying record number 61840

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HXB2 Location	Pol(748-758) Integrase(33-43) DNA(4326..4358)	Pol Epitope Map
Author Location
Epitope	AKEIVASCDKC	Epitope Alignment
Epitope Name	AC11
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID404: A*68:01, B*44:02, B*51:01, C*07:04, C*14:02, DQB1*06:02, DQB1*06:05, DRB1*13:01, DRB1*13:02, DRB3
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Novel peptide AKEIVASCDKC (AC11) is within peptide DKAQAKEIVASCDKC (HC139) that was recognized by VID 404, 1/12 vaccinated subjects. AC11 is novel, but of unknown restriction, though two epitopes are predicted within it to be AKEIVASCDKC (EK8) and AKEIVASCDKC (KC10) predicted to be restricted by HLA-A*67801 and HLA-B*4402 respectively.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.