HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 24 matching records:

Displaying record number 57406

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 59539

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58759

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name Vpr-AL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 56714

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr( HIV-1 NL4-3.1)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Cruz2009 Justin De La Cruz, Ayub Ali, Hwee L Ng, and Otto O Yang. Disruption of an env Tyrosine-Dependent Sorting Signal Does Not Affect Susceptibility of HIV-1 to Cytotoxic T Lymphocytes. AIDS, 23(11):1449-1451, 17 Jul 2009. PubMed ID: 19564727. Show all entries for this paper.


Displaying record number 55249

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, optimal epitope

Notes

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.


Displaying record number 58011

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Show epitope variants
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing, escape

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 1983

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name Vpr-AL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 61200

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Japan
Experimental methods Other
Keywords HLA associated polymorphism

Notes

References

Kamori2017 Doreen Kamori, Zafrul Hasan, Jun Ohashi, Ai Kawana-Tachikawa, Hiroyuki Gatanaga, Shinichi Oka, and Takamasa Ueno. Identification of Two Unique Naturally Occurring Vpr Sequence Polymorphisms Associated with Clinical Parameters in HIV-1 Chronic Infection. J. Med. Virol., 89(1):123-129, Jan 2017. PubMed ID: 27328918. Show all entries for this paper.


Displaying record number 1266

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(58-66 SF2)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Altfeld2001c M. Altfeld, M. M. Addo, R. L. Eldridge, X. G. Yu, S. Thomas, A. Khatri, D. Strick, M. N. Phillips, G. B. Cohen, S. A. Islam, S. A. Kalams, C. Brander, P. J. Goulder, E. S. Rosenberg, B. D. Walker, and The HIV Study Collaboration.. Vpr is preferentially targeted by CTL during HIV-1 infection. J. Immunol., 167(5):2743-52, 1 Sep 2001. URL: http://www.jimmunol.org/cgi/content/full/167/5/2743. PubMed ID: 11509618. Show all entries for this paper.


Displaying record number 1310

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name Vpr-59
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, immunodominance, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 52409

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(58-66)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords early-expressed proteins

Notes

References

Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.


Displaying record number 52642

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A32, B49, B51, Cw1, Cw7
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 55284

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A19, B*3501, B44, Cw16, Cw7; A*0201, A19, B14, B44, Cw16, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, mother-to-infant transmission, rate of progression, escape, co-receptor, mutation acquisition, HLA associated polymorphism

Notes

References

Reinis2007 Milan Reinis, Barbara Weiser, Carla Kuiken, Tao Dong, Dorothy Lang, Sharon Nachman, Yonghong Zhang, Sarah Rowland-Jones, and Harold Burger. Genomic Analysis of HIV Type 1 Strains Derived from a Mother and Child Pair of Long-Term Nonprogressors. AIDS Res. Hum. Retroviruses, 23(2):309-315, Feb 2007. PubMed ID: 17331038. Show all entries for this paper.


Displaying record number 58866

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, optimal epitope, HLA associated polymorphism

Notes

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 1190

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(58-66 LAI)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55908

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9(Vpr)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54226

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name A2-AL9(Vpr)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 1532

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67 SF2)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1287

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 55486

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords superinfection

Notes

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.


Displaying record number 1600

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 59540

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(C*16)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52064

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location  
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, escape

Notes

References

Yusim2002 Karina Yusim, Can Kesmir, Brian Gaschen, Marylyn M. Addo, Marcus Altfeld, S\oren Brunak, Alexandre Chigaev, Vincent Detours, and Bette T. Korber. Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation. J. Virol., 76(17):8757-8768, Sep 2002. PubMed ID: 12163596. Show all entries for this paper.


Displaying record number 55808

HXB2 Location Vpr(59-67)
DNA(5733..5759)
Vpr Epitope Map
Author Location Vpr(59-67)
Epitope AIIRILQQL Epitope Alignment
AIIRILQQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Srinivasan2008 Alagarsamy Srinivasan, Velpandi Ayyavoo, Sundarasamy Mahalingam, Aarthi Kannan, Anne Boyd, Debduti Datta, Vaniambadi S. Kalyanaraman, Anthony Cristillo, Ronald G. Collman, Nelly Morellet, Bassel E. Sawaya, and Ramachandran Murali. A Comprehensive Analysis of the Naturally Occurring Polymorphisms in HIV-1 Vpr: Potential Impact on CTL Epitopes. Virol. J., 5:99, 2008. PubMed ID: 18721481. Show all entries for this paper.


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