HIV molecular immunology database
Found 67 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other | |
Keywords | elite controllers, neutralization by CTL |
Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(101-) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | Pol313 | |
Subtype | A | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection, vaccine | |
Country | Guinea-Bissau | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection |
Vaccine type | peptide |
---|---|
Vaccine strain | A clade |
Adjuvant | CAF01 |
Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | Pol 325-333 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | vaccine | |
Country | France | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding | |
Keywords | vaccine-induced immune responses |
Vaccine type | lipopeptide |
---|
Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression |
Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | S00009: A*03, A*26, B*15, B*38, C*03, C*12 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, chronic infection |
Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Chromium-release assay, In vitro proteasome digestion | |
Keywords | epitope processing |
Boucau2019 Julie Boucau, Julien Madouasse, Georgio Kourjian, Christopher S. Carlin, Daniel Wambua, Matthew J. Berberich, and Sylvie Le Gall. The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner. J. Immunol., 202(10):2856-2872, 15 May 2019. PubMed ID: 30936293. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT Pol(313-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03, A*11) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Chromium-release assay, Cytotoxicity assay, Other | |
Keywords | epitope processing |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166 NL4.3) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03, A*11) | |
Immunogen | HIV-1 infected monocyte-derived | |
Country | United States | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, dendritic cells |
Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03, A*11) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | escape, HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(347-) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | vaccine | |
Country | Botswana, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | vaccine antigen design |
Vaccine type | DNA, polyepitope |
---|---|
Vaccine strain | multiple epitope immunogen |
Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | responses in children, mother-to-infant transmission |
Brander1995a Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. pages IV--1--IV--9. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1995. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection |
Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Zimbwa2007 Peter Zimbwa, Anita Milicic, John Frater, Thomas J. Scriba, Antony Willis, Philip J. R. Goulder, Tilly Pillay, Huldrych Gunthard, Jonathan N. Weber, Hua-Tang Zhang, and Rodney E. Phillips. Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant. J. Virol., 81(4):2031-2038, Feb 2007. PubMed ID: 17108020. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | 1339 | |
Subtype | multiple | |
Species (MHC/HLA) | human(A*03:01, A*68:01, A11, A3, A33) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A3, B51, B8, Cw1, Cw7; A26, A3, B52, B8; A11, A3, B14, B5, Cw8 | |
Country | United States | |
Experimental methods | T-cell Elispot | |
Keywords | binding affinity, supertype, computational epitope prediction, HLA cross-presentation |
DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01, A11, A33) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B | |
Keywords | Th1, characterizing CD8+ T cells |
Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | A, B, C, D | |
Species (MHC/HLA) | human, macaque(A*03:01, A11, A33) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(A*03:01, A*11:01, A*68:01, A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Threlkeld1997 S. C. Threlkeld, P. A. Wentworth, S. A. Kalams, B. M. Wilkes, D. J. Ruhl, E. Kepgh, J. Sidney, S. Southwood, B. D. Walker, and A. Sette. Degenerate and Promiscuous Recognition by CTL of Peptides Presented by the MHC Class I A3-Like Superfamily. J. Immunol., 159(4):1648-1657, 1997. Similarities in peptide binding across A3-like superfamily results in similar peptide-MHC complex structures engaged by T-cell receptors. PubMed ID: 9257824. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | P3 | |
Subtype | B | |
Species (MHC/HLA) | human(A03 supertype) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supertype |
Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(305-313 93TH253 subtype CRF01) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | CRF01_AE | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166 NL4.3) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | In vitro proteasome digestion, Other | |
Keywords | epitope processing |
Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166 IIIB) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | epitope processing, escape |
Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(305-313 93TH253 subtype CRF01) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | P313-321 | |
Subtype | CRF01_AE | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(314-322) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords |
Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | ||
Keywords |
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Zhang1993 Q.-I. Zhang, R. Gavioli, G. Klein, and M. G. Masucci. An HLA-A11-Specific Motif in Nonamer Peptides Derived from Viral And Cellular Proteins. Proc. Natl. Acad. Sci. U.S.A., 90:2217-2221, 1993. PubMed ID: 8384718. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(314-322) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01, A*11, B*08, B*15, C*04, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | escape, optimal epitope |
Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | A11-AK9 (RT) | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Wagner1998b L. Wagner, O. O. Yang, E. A. Zepeda, Y. Ge, S. A. Kalams, B. D. Walker, M. S. Pasternack, and A. D. Luster. Beta-Chemokines Are Released from HIV-1-Specific Cytolytic T Cell Granules Complexed to Proteoglycans. Nature, 391:908-911, 1998. PubMed ID: 9495345. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review |
McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT( B consensus) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | ATK9 | |
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5; A3, B14, B60, Cw3, Cw7; A1, A3, B14, B8, Cw7, Cw8 | |
Country | United States | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | HLA cross-presentation, assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11, A3, A33) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(325-333) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | (A11, A3, A33, A68) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | HLA binding | |
Keywords | binding affinity, immunodominance |
Racape2006a Judith Racape, Francine Connan, Johan Hoebeke, Jeannine Choppin, and Jean-Gérard Guillet. Influence of Dominant HIV-1 Epitopes on HLA-A3/Peptide Complex Formation. Proc. Natl. Acad. Sci. U.S.A., 103(48):18208-18213, 28 Nov 2006. PubMed ID: 17116886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | VID421: A*02:01, A*11:01, B*35:03, B*40:02, C*02:02, C*12:03 | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | vaccine-induced immune responses, optimal epitope |
Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B, CRF01_AE | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Fukada2002 Katsuhiko Fukada, Hiroko Tomiyama, Chantapong Wasi, Tomoko Matsuda, Shigeru Kusagawa, Hironori Sato, Shinichi Oka, Yutaka Takebe, and Masafumi Takiguchi. Cytotoxic T-cell Recognition of HIV-1 Cross-Clade and Clade-Specific Epitopes in HIV-1-Infected Thai and Japanese Patients. AIDS, 16(5):701-711, 29 Mar 2002. PubMed ID: 11964526. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(313-321) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Subtype | B, CRF01_AE | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | ||
Country | Thailand | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), structure |
Li2004 Lenong Li and Marlene Bouvier. Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. J. Immunol., 172(10):6175-6184, 15 May 2004. PubMed ID: 15128805. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | A, B, C, D | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | vaccine-induced immune responses, immunodominance |
Ahmed2016 Tina Ahmed, Nicola J. Borthwick, Jill Gilmour, Peter Hayes, Lucy Dorrell, and Tomáš Hanke. Control of HIV-1 Replication In Vitro by Vaccine-Induced Human CD8+ T Cells through Conserved Subdominant Pol Epitopes. Vaccine, 34(9):1215-1224, 24 Feb 2016. PubMed ID: 26784683. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection, vaccine | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | vaccine-induced immune responses |
Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | Pol347 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | vaccine | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine antigen design |
Vaccine type | DNA, polyepitope |
---|---|
Vaccine component | other |
Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | A3-ATK9(RT) | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B57, B7, Cw6, Cw7 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | Pol313 | |
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal | |
Experimental methods | Intracellular cytokine staining, Pentamer labeling | |
Keywords | vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Show epitope variants | ||
Epitope Name | A3-AK9 Pol | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supervised treatment interruptions (STI), escape, early treatment, superinfection |
Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | RT Pol(313-321) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Epitope Name | A3-ATK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | RT(325-333 SF2) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | Pol(325-333 IIIB) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Show epitope variants | ||
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | responses in children, mother-to-infant transmission, escape |
Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | RT(325-333 IIIB) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | responses in children, mother-to-infant transmission |
Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | RT(325-333 LAI) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Subtype | B | |
Species (MHC/HLA) | human(A33) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Rowland-JonesPerCom1995 S. Rowland-Jones. Personal communication, 1995. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | ||
Epitope |
AIFQSSMTK
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Epitope Alignment
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Species (MHC/HLA) | human(A33) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | Pol | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Epitope Name | Pol347 | |
Subtype | A, B, C, D | |
Species (MHC/HLA) | human, mouse(A3 supertype) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation |
Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | Pol(337-345) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Species (MHC/HLA) | human(A3 supertype) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | supertype, rate of progression |
Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Epitope Name | AK9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*68:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A*68:01, B51, B8, C*15, Cw7, DQ2, DQ3, DR3, DR4 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, escape, mutation acquisition |
Kemal2008 Kimdar Sherefa Kemal, Tara Beattie, Tao Dong, Barbara Weiser, Rupert Kaul, Carla Kuiken, Julian Sutton, Dorothy Lang, Hongbing Yang, Yan Chun Peng, Ronald Collman, Sean Philpott, Sarah Rowland-Jones, and Harold Burger. Transition from Long-Term Nonprogression to HIV-1 Disease Associated with Escape from Cellular Immune Control. J. Acquir. Immune Defic. Syndr., 48(2):119-126, 1 Jun 2008. PubMed ID: 18520675. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Show epitope variants | ||
Epitope Name | AK9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | structure, vaccine antigen design |
Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | Pol | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, computational epitope prediction, vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | Pol | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus type 5 (Ad5), DNA prime with Ad5 boost |
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Vaccine strain | B clade IIIB, B clade JRFL, B clade CAM-1 |
Vaccine component | Gag, Nef, Pol |
Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.
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HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
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Author Location | Pol(973-) | |
Epitope |
AIFQSSMTK
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Epitope Alignment
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Epitope Name | AK9 | |
Subtype | A3, B, C, CRF02_AG | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Denmark, Guinea-Bissau | |
Experimental methods | HLA binding, Intracellular cytokine staining, Tetramer binding | |
Keywords | binding affinity, vaccine antigen design, non-susceptible form |
Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(313-321) RT(158-166) DNA(3021..3047) |
Pol Epitope Map |
---|---|---|
Author Location | RT(158-166) | |
Epitope |
AIFQSSMTK
|
Epitope Alignment
|
Epitope Name | AK9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | acute/early infection, HLA associated polymorphism, chronic infection, protective allele |
Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.