HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 63 matching records:

Displaying record number 59538

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53101

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT Pol(313-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 59306

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 59216

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name Pol 325-333
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen vaccine
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type lipopeptide

Notes

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.


Displaying record number 1776

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 59003

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(101-)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name Pol313
Subtype A
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection, vaccine
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 57045

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other
Keywords elite controllers, neutralization by CTL

Notes

References

Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.


Displaying record number 59125

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166 NL4.3)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Subtype B
Species (MHC/HLA) human(A*03, A*11)
Immunogen HIV-1 infected monocyte-derived
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 56383

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype B
Species (MHC/HLA) human(A*03, A*11)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 58005

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location  
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Subtype B
Species (MHC/HLA) human(A*03, A*11)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 1117

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location  
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 448

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Brander1995a Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. pages IV--1--IV--9. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1995. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 1116

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56195

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(347-)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 1118

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 55350

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Zimbwa2007 Peter Zimbwa, Anita Milicic, John Frater, Thomas J. Scriba, Antony Willis, Philip J. R. Goulder, Tilly Pillay, Huldrych Gunthard, Jonathan N. Weber, Hua-Tang Zhang, and Rodney E. Phillips. Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant. J. Virol., 81(4):2031-2038, Feb 2007. PubMed ID: 17108020. Show all entries for this paper.


Displaying record number 52893

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name 1339
Subtype multiple
Species (MHC/HLA) human(A*0301, A*6801, A11, A3, A33)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B51, B8, Cw1, Cw7; A26, A3, B52, B8; A11, A3, B14, B5, Cw8
Country United States
Experimental methods T-cell Elispot
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.


Displaying record number 52428

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human, macaque(A*0301, A11, A33)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 53024

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301, A11, A33)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 446

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0301, A*1101, A*6801, A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Threlkeld1997 S. C. Threlkeld, P. A. Wentworth, S. A. Kalams, B. M. Wilkes, D. J. Ruhl, E. Kepgh, J. Sidney, S. Southwood, B. D. Walker, and A. Sette. Degenerate and Promiscuous Recognition by CTL of Peptides Presented by the MHC Class I A3-Like Superfamily. J. Immunol., 159(4):1648-1657, 1997. Similarities in peptide binding across A3-like superfamily results in similar peptide-MHC complex structures engaged by T-cell receptors. PubMed ID: 9257824. Show all entries for this paper.


Displaying record number 1500

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name P3
Subtype B
Species (MHC/HLA) human(A03 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supertype

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 1721

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(305-313 93TH253 subtype CRF01)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name P313-321
Subtype CRF01_AE
Species (MHC/HLA) human(A11)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.


Displaying record number 52068

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166 IIIB)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, escape

Notes

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.


Displaying record number 53479

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(314-322)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 54260

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name A11-AK9 (RT)
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 445

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Wagner1998b L. Wagner, O. O. Yang, E. A. Zepeda, Y. Ge, S. A. Kalams, B. D. Walker, M. S. Pasternack, and A. D. Luster. Beta-Chemokines Are Released from HIV-1-Specific Cytolytic T Cell Granules Complexed to Proteoglycans. Nature, 391:908-911, 1998. PubMed ID: 9495345. Show all entries for this paper.


Displaying record number 53752

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Epitope Name AK9
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A*01, A*11, B*08, B*15, Cw*04, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 450

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 53558

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(314-322)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 449

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Zhang1993 Q.-I. Zhang, R. Gavioli, G. Klein, and M. G. Masucci. An HLA-A11-Specific Motif in Nonamer Peptides Derived from Viral And Cellular Proteins. Proc. Natl. Acad. Sci. U.S.A., 90:2217-2221, 1993. PubMed ID: 8384718. Show all entries for this paper.


Displaying record number 57829

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Subtype B
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 1429

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 53350

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT( B consensus)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5; A3, B14, B60, Cw3, Cw7; A1, A3, B14, B8, Cw7, Cw8
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HLA cross-presentation, assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 1654

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A11, A3, A33)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 54959

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) (A11, A3, A33, A68)
Immunogen peptide-HLA interaction
Experimental methods HLA binding
Keywords binding affinity, immunodominance

Notes

References

Racape2006a Judith Racape, Francine Connan, Johan Hoebeke, Jeannine Choppin, and Jean-Gérard Guillet. Influence of Dominant HIV-1 Epitopes on HLA-A3/Peptide Complex Formation. Proc. Natl. Acad. Sci. U.S.A., 103(48):18208-18213, 28 Nov 2006. PubMed ID: 17116886. Show all entries for this paper.


Displaying record number 59191

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166 NL4.3)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Subtype B
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 59537

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name ATK9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1741

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(305-313 93TH253 subtype CRF01)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype CRF01_AE
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1126

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52099

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Fukada2002 Katsuhiko Fukada, Hiroko Tomiyama, Chantapong Wasi, Tomoko Matsuda, Shigeru Kusagawa, Hironori Sato, Shinichi Oka, Yutaka Takebe, and Masafumi Takiguchi. Cytotoxic T-cell Recognition of HIV-1 Cross-Clade and Clade-Specific Epitopes in HIV-1-Infected Thai and Japanese Patients. AIDS, 16(5):701-711, 29 Mar 2002. PubMed ID: 11964526. Show all entries for this paper.


Displaying record number 61328

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype A, B, C, D
Species (MHC/HLA) human(A*1101)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, immunodominance

Notes

References

Ahmed2016 Tina Ahmed, Nicola J. Borthwick, Jill Gilmour, Peter Hayes, Lucy Dorrell, and Tomáš Hanke. Control of HIV-1 Replication In Vitro by Vaccine-Induced Human CD8+ T Cells through Conserved Subdominant Pol Epitopes. Vaccine, 34(9):1215-1224, 24 Feb 2016. PubMed ID: 26784683. Show all entries for this paper.


Displaying record number 53048

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*1101)
Immunogen  
Country Thailand
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), structure

Notes

References

Li2004 Lenong Li and Marlene Bouvier. Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. J. Immunol., 172(10):6175-6184, 15 May 2004. PubMed ID: 15128805. Show all entries for this paper.


Displaying record number 61818

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location  
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA VID421: A*0201, A*1101, B*3503, B*4002, Cw*0202, Cw*1203; VID421: A*0201, A*1101, B*3503, B*4002, Cw*0202, Cw*1203
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, optimal epitope

Notes

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.


Displaying record number 61875

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location  
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 444

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 IIIB)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


Displaying record number 53503

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 52974

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 52826

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Epitope Name A3-AK9 Pol
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape, early treatment, superinfection

Notes

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 54252

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name A3-ATK9(RT)
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52146

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT Pol(313-321)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name A3-ATK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 56538

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name Pol347
Subtype B
Species (MHC/HLA) human(A3)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component Other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 1524

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 SF2)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 58417

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name Pol313
Subtype B, CRF02_AG
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 452

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(325-333 IIIB)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 447

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 1331

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location  
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A33)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.


Displaying record number 451

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A33)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Rowland-JonesPerCom1995 S. Rowland-Jones. Personal communication, 1995. Show all entries for this paper.


Displaying record number 56517

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name Pol347
Subtype A, B, C, D
Species (MHC/HLA) human, mouse(A3 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


Displaying record number 1615

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(337-345)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Species (MHC/HLA) human(A3 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 55540

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(158-166)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype B
Species (MHC/HLA) human(A*6801)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A*6801, B51, B8, Cw15, Cw7, DQ2, DQ3, DR3, DR4
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, mutation acquisition

Notes

References

Kemal2008 Kimdar Sherefa Kemal, Tara Beattie, Tao Dong, Barbara Weiser, Rupert Kaul, Carla Kuiken, Julian Sutton, Dorothy Lang, Hongbing Yang, Yan Chun Peng, Ronald Collman, Sean Philpott, Sarah Rowland-Jones, and Harold Burger. Transition from Long-Term Nonprogression to HIV-1 Disease Associated with Escape from Cellular Immune Control. J. Acquir. Immune Defic. Syndr., 48(2):119-126, 1 Jun 2008. PubMed ID: 18520675. Show all entries for this paper.


Displaying record number 58064

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 61952

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol(973-)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Epitope Name AK9
Subtype A3 (CRF02_AG+C), B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design, non-susceptible form

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


Displaying record number 56955

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location Pol
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


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