HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 59007

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HXB2 Location Pol(592-600)
RT(437-445)
DNA(3858..3884)
Pol Epitope Map
Author Location Pol(592-)
Epitope AETFYVDGA Epitope Alignment
AETFYVDGA epitope logo
Epitope Name Pol592
Subtype A
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P4: A*30:02, A*68:01, B*56:01, B*58:01; P7: A*26:01, A*68:01, B*08:01
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 58420

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HXB2 Location Pol(592-600)
RT(437-445)
DNA(3858..3884)
Pol Epitope Map
Author Location Pol
Epitope AETFYVDGA Epitope Alignment
AETFYVDGA epitope logo
Epitope Name Pol592
Subtype B, CRF02_AG
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 1972

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HXB2 Location Pol(592-600)
RT(437-445)
DNA(3858..3884)
Pol Epitope Map
Author Location RT(437-445)
Epitope AETFYVDGA Epitope Alignment
AETFYVDGA epitope logo
Epitope Name Pol-AA9; RT-AA9
Subtype B
Species (MHC/HLA) human(B*45:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*30:02, A*32:01, B*45:01, B*53:01, C*04:01, C*12:02; 00RCH33: A*30:02, A*32:01, B*45:01, B*53:01, C*04:01, C*12:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 61959

Download this epitope record as JSON.

HXB2 Location Pol(592-600)
RT(437-445)
DNA(3858..3884)
Pol Epitope Map
Author Location Pol(592-)
Epitope AETFYVDGA Epitope Alignment
AETFYVDGA epitope logo
Epitope Name AA9
Subtype A3, B, C, CRF02_AG
Species (MHC/HLA) human(B*45:01, B*50:01)
Immunogen HIV-1 infection
Patient MHC/HLA 1108: ; 1115: A*02:01, A*68:01, B*50:01, B*58:01
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


Displaying record number 56953

Download this epitope record as JSON.

HXB2 Location Pol(592-600)
RT(437-445)
DNA(3858..3884)
Pol Epitope Map
Author Location Pol
Epitope AETFYVDGA Epitope Alignment
AETFYVDGA epitope logo
Subtype A1
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


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