HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 30 matching records:

Displaying record number 59526

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*15:03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59527

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*15:24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59525

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59521

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*35:01, B*35:08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62118

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(306-316 NL4-3)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Species (MHC/HLA) human(B*44)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 56347

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B, C
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 56374

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Subtype B
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 58543

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name B44-AW11
Subtype B
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 61614

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name Gag B44-AW11
Subtype B
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Patient MHC/HLA 9213: A*01, A*24, B*38, B*44, C*04
Country Germany, Switzerland, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords escape, acute/early infection, assay or method development

Notes

References

Henn2012 Matthew R. Henn, Christian L. Boutwell, Patrick Charlebois, Niall J. Lennon, Karen A. Power, Alexander R. Macalalad, Aaron M. Berlin, Christine M. Malboeuf, Elizabeth M. Ryan, Sante Gnerre, Michael C. Zody, Rachel L. Erlich, Lisa M. Green, Andrew Berical, Yaoyu Wang, Monica Casali, Hendrik Streeck, Allyson K. Bloom, Tim Dudek, Damien Tully, Ruchi Newman, Karen L. Axten, Adrianne D. Gladden, Laura Battis, Michael Kemper, Qiandong Zeng, Terrance P. Shea, Sharvari Gujja, Carmen Zedlack, Olivier Gasser, Christian Brander, Christoph Hess, Huldrych F. Günthard, Zabrina L. Brumme, Chanson J. Brumme, Suzane Bazner, Jenna Rychert, Jake P. Tinsley, Ken H. Mayer, Eric Rosenberg, Florencia Pereyra, Joshua Z. Levin, Sarah K. Young, Heiko Jessen, Marcus Altfeld, Bruce W. Birren, Bruce D. Walker, and Todd M. Allen. Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection. PLoS Pathog., 8(3):e1002529, 2012. PubMed ID: 22412369. Show all entries for this paper.


Displaying record number 59522

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1498

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(306-316 LAI)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name G3
Subtype B
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 1807

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(174-184)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 58511

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(18-)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*44, B*57, C*04)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 52281

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name B44-AW11(p24)
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Patient MHC/HLA A32, B44
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 57837

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 53353

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location ( B consensus)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, C*12, Cw5; A28, A29, B14, B44, Cw8
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53478

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, C*12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 53557

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, C*12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53688

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Show epitope variants
Subtype B, D
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Patient MHC/HLA A23, A34, B44, B53, Cw4, Cw6; M12020: A*23, A*34, B*44, B*53, C*04, C*06
Country Democratic Republic of the Congo
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, variant cross-reactivity

Notes

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 54369

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name B44-AW11(p24)
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55043

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location  
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55506

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords dynamics, characterizing CD8+ T cells, chronic infection

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55188

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location  
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 336

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(306-316 LAI)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*44:02, B44)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Brander1997 Christian Brander and Bruce Walker. Systematic Identification of Optimal HIV-1 CTL Epitopes. In Systematic Identification of Optimal HIV-1 CTL Epitopes. pages IV--1--IV--11. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1997. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 60912

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(174-184)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*44:02)
Immunogen HIV-1 infection
Patient MHC/HLA 98621: A*02:01:01G, B*40:01:01G, B*44:02:01G, C*03:04:01G, C*05:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 337

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(306-316 LAI)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*44:02)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59523

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*45)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59520

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59524

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location Gag(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Epitope Name AW11
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62821

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HXB2 Location Gag(306-316)
p24(174-184)
DNA(1705..1737)
Gag Epitope Map
Author Location p24(306-316)
Epitope AEQASQDVKNW Epitope Alignment
AEQASQDVKNW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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