HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 59515

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location Env(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Species (MHC/HLA) human(B*1517)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59514

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location Env(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Species (MHC/HLA) human(B*1540)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59512

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location Env(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58157

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp120(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Epitope Name AY9
Subtype B
Species (MHC/HLA) human(B*1801)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 54101

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location  
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Species (MHC/HLA) human(B*1801)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54160

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp120(31-39 HIV-MN)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Epitope Name AY9
Subtype B
Species (MHC/HLA) human(B*1801)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 59090

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp120(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*1801)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 55042

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location  
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 1557

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp120(30-38 SF2)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52112

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp120
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Cao2002 Huyen Cao, Deepak Agrawal, Nicholas Kushner, Neal Touzjian, Max Essex, and Yichen Lu. Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol. J. Infect. Dis., 185(2):244-251, 15 Jan 2002. PubMed ID: 11807699. Show all entries for this paper.


Displaying record number 53362

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location ( B consensus)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A29, B44, B8, Cw4, Cw7
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 622

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp160(30-39 WEAU)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance, escape

Notes

References

Borrow1997 P. Borrow, H. Lewicki, X. Wei, M. S. Horwitz, N. Peffer, H. Meyers, J. A. Nelson, J. E. Gairin, B. H. Hahn, M. B. Oldstone, and G. M. Shaw. Anti-Viral Pressure Exerted by HIV-1-Specific Cytotoxic T Lymphocytes (CTLs) During Primary Infection Demonstrated by Rapid Selection of CTL Escape Virus. Nat. Med., 3:205-211, 1997. Genetic pathways of virus escape from CTL pressure resembled virus escape from antiretroviral therapy. PubMed ID: 9018240. Show all entries for this paper.

Borrow1998 P. Borrow and G. M. Shaw. Cytotoxic T-Lymphocyte Escape Viral Variants: How Important Are They in Viral Evasion of Immune Clearance In Vivo? Immunol. Rev., 164:37-51, 1998. PubMed ID: 9795762. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 56044

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp120
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9(gp120)
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54105

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location  
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Species (MHC/HLA) human(B*44)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57436

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp160
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Epitope Name AY9
Subtype B
Species (MHC/HLA) human(B*4403)
Immunogen HIV-1 infection
Country United States
Experimental methods Chromium-release assay
Keywords escape, acute/early infection

Notes

References

Fischer2010 Will Fischer, Vitaly V. Ganusov, Elena E. Giorgi, Peter T. Hraber, Brandon F. Keele, Thomas Leitner, Cliff S. Han, Cheryl D. Gleasner, Lance Green, Chien-Chi Lo, Ambarish Nag, Timothy C. Wallstrom, Shuyi Wang, Andrew J. McMichael, Barton F. Haynes, Beatrice H. Hahn, Alan S. Perelson, Persephone Borrow, George M. Shaw, Tanmoy Bhattacharya, and Bette T. Korber. Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing. PLoS One, 5(8):e12303, 2010. PubMed ID: 20808830. Show all entries for this paper.


Displaying record number 53226

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp160(30-38 WEAU)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Epitope Name gp160 AY9
Species (MHC/HLA) human(B*4403)
Immunogen HIV-1 infection
Patient MHC/HLA A*2902, B*0801, B*4403
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords dynamics, immunodominance, escape, acute/early infection, kinetics, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.


Displaying record number 59513

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location Env(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Epitope Name AY9
Species (MHC/HLA) human(C*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54677

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp160(31-39)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A1, A29, B44, B8
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


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