HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 28 matching records:

Displaying record number 57517

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location  
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 59504

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1187

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24( SF2)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 1370

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name ACQ
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA SC19: A*11, A*29, B*08, B*44, Cw*06, Cw*0701, DQ2, DQ8, DR3, DR52, DR53, DR7; SC18: A*02, A*11, B*50, B*58, Bw4, Bw6, Cw*0401, Cw10, DQ2, DQ8, DR3, DR4, DR52, DR53
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1440

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(216-226)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1540

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(349-359 SF2)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52316

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name ACQ
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 53361

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location ( B consensus)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A29, B44, B8, Cw4, Cw7
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53474

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Show epitope variants
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, TCR usage, variant cross-reactivity

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 53501

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 54539

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(217-227)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Show epitope variants
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54257

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name A11-AK11(p24)
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 360

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(349-359 IIIB)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Show epitope variants
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 62120

HXB2 Location Gag(349-359)
p24(217-227)
Gag Epitope Map
Author Location p24(349-359 NL4-3)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Species (MHC/HLA) human(A*11)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 56364

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57348

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, supervised treatment interruptions (STI), early treatment, elite controllers

Notes

References

Streeck2009 Hendrik Streeck, Heiko Jessen, Claudia Kuecherer, Bin Li, Arne B. Jessen, Stephan Dupke, Axel Baumgarten, Ingrid Stahmer, Jan van Lunzen, Marcus Altfeld, Bruce D. Walker, and Todd M. Allen. Epidemiologically Linked Transmission of HIV-1 Illustrates the Impact of Host Genetics on Virological Outcome. AIDS, 23(2):259-262, 14 Jan 2009. PubMed ID: 19098497. Show all entries for this paper.


Displaying record number 57710

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape

Notes

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 58549

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name A11-AK11
Subtype B
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 59502

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57644

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name Gag349
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Country Japan
Experimental methods HLA binding, Intracellular cytokine staining, Relative replication capacity assay, Tetramer binding
Keywords rate of progression, immunodominance

Notes

References

Koizumi2010 Hirokazu Koizumi, Masao Hashimoto, Mamoru Fujiwara, Hayato Murakoshi, Takayuki Chikata, Mohamed Ali Borghan, Atsuko Hachiya, Yuka Kawashima, Hiroshi Takata, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi. Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses. J. Virol., 84(11):5508-5519, Jun 2010. PubMed ID: 20335254. Show all entries for this paper.


Displaying record number 61790

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location  
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords vaccine-induced immune responses, variant cross-reactivity

Notes

References

Murakoshi2018 Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. CD8+ T Cells Specific for Conserved, Cross-Reactive Gag Epitopes with Strong Ability to Suppress HIV-1 Replication. Retrovirology, 15(1):46, 3 Jul 2018. PubMed ID: 29970102. Show all entries for this paper.


Displaying record number 361

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location p24(349-359 IIIB)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52104

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, TCR usage

Notes

References

Fukada2002 Katsuhiko Fukada, Hiroko Tomiyama, Chantapong Wasi, Tomoko Matsuda, Shigeru Kusagawa, Hironori Sato, Shinichi Oka, Yutaka Takebe, and Masafumi Takiguchi. Cytotoxic T-cell Recognition of HIV-1 Cross-Clade and Clade-Specific Epitopes in HIV-1-Infected Thai and Japanese Patients. AIDS, 16(5):701-711, 29 Mar 2002. PubMed ID: 11964526. Show all entries for this paper.


Displaying record number 57377

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location  
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Show epitope variants
Epitope Name AK11 wt
Species (MHC/HLA) human(A*1101)
Immunogen in vitro stimulation or selection, peptide-HLA interaction
Country United States
Experimental methods Other
Keywords binding affinity, escape

Notes

References

Yang2010 Yue Yang, Jinghe Huang, Ildiko Toth, Mathias Lichterfeld, and Xu G. Yu. Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors. PLoS One, 5(12):e15084, 2010. PubMed ID: 21170342. Show all entries for this paper.


Displaying record number 61178

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Show epitope variants
Epitope Name AK11
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 53249

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359 SUMA)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name Gag AK11
Subtype B
Species (MHC/HLA) human(A*1103)
Immunogen HIV-1 infection
Patient MHC/HLA A*1103, A*2402, B*1402, B*1501, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords dynamics, acute/early infection, characterizing CD8+ T cells

Notes

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.


Displaying record number 59503

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59505

HXB2 Location Gag(349-359)
p24(217-227)
DNA(1834..1866)
Gag Epitope Map
Author Location Gag(349-359)
Epitope ACQGVGGPGHK Epitope Alignment
ACQGVGGPGHK epitope logo
Epitope Name AK11
Species (MHC/HLA) human(B*82)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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