HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 30 matching records:

Displaying record number 54564

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Show epitope variants
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 53848

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Show epitope variants
Epitope Name AL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA P-1031: A*02, A*30, B*13, B*18, Cw*01, Cw*05; M-1002: A*30, B*18, B*40, Cw*02, Cw*05; M-1005: A*02, A*32, B*07, B*40, Cw*03, Cw*07; P-1026: A*24, A*32, B*07, B*18, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 58757

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name Nef-AL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 60911

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA 98621: A*0201, A*0201, B*4001, B*4401, Cw*0304, Cw*0501
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 59501

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53766

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91 HXB2)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Viet Nam
Experimental methods HLA binding
Keywords subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


Displaying record number 52114

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91 BRU)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 55482

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype A1, B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 52940

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 53718

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91 BRU)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Show epitope variants
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 54277

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name A68-AL(Nef)
Species (MHC/HLA) human(A68)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 59496

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61746

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(B*14)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59414

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance, novel epitope

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 59498

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61747

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(B*58)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59415

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(B*58)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance, novel epitope

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 59500

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52620

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Species (MHC/HLA) human(B60, B62, Cw*0802, Cw8)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A23, B44, B62, Cw3, Cw4; A1, A3, B14, B7, Cw*0702, Cw*0802; A*0201, A31, B44, B60, Cw16, Cw3; A1, A1, B14, B8, Cw7, Cw8
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, early treatment

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 54541

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Show epitope variants
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(B62, Cw8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, assay or method development, mutation acquisition

Notes

References

Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.


Displaying record number 59497

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59495

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59494

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(C*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59499

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59416

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(Cw*03)
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-10: A*11, A*30, B*15, B*52, Cw*03, Cw*12; LTNP/EC-11: A*33, A*68, B*14, B*15, Cw*02, Cw*08
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 54801

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Species (MHC/HLA) human(Cw*03)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 57250

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Show epitope variants
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(Cw*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B, Flow cytometric T-cell cytokine assay, Proliferation
Keywords acute/early infection

Notes

References

Malhotra2009 U. Malhotra, J. Nolin, H. Horton, F. Li, L. Corey, J. I. Mullins, and M. J. McElrath. Functional Properties and Epitope Characteristics of T-Cells Recognizing Natural HIV-1 Variants. Vaccine, 27(48):6678-6687, 12 Nov 2009. PubMed ID: 19747576. Show all entries for this paper.


Displaying record number 1157

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91 LAI)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Subtype B
Species (MHC/HLA) human(Cw*0802)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56419

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location Nef(83-91)
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Epitope Name AL9
Subtype B
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 54914

HXB2 Location Nef(83-91)
DNA(9043..9069)
Nef Epitope Map
Author Location  
Epitope AAVDLSHFL Epitope Alignment
AAVDLSHFL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0101; B*0801, B*1401
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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