Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 53767

Download this epitope record as JSON.

HXB2 Location	Nef(83-90) DNA(9043..9066)	Nef Epitope Map
Author Location	Nef(83-90 HXB2)
Epitope	AAVDLSHF	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(B*62)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE variant gAfDLSfF had a higher HLA-B*62 binding score than the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.