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Displaying record number 55065

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HXB2 Location	Nef(83-91) DNA(9043..9069)	Nef Epitope Map
Author Location	Nef(83-91)
Epitope	AALDMSHFL	Epitope Alignment
		Show epitope variants
Epitope Name	AL9
Species (MHC/HLA)	human(Cw3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02:01, A*24:02, B*40:01, B*50:01, C*03, Cw4
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	immunodominance, escape, variant cross-reactivity, characterizing CD8+ T cells

Notes

• HIV-specific cellular and humoral immune responses were examined in monozygotic male twins infected simultaneously with the same virus. 15 of 17 targeted epitopes were identical in the twins, including two immunodominant responses. 3 of 4 declining responses in the twins showed mutations at the same residue. Evolving antibody responses cross-neutralized the other twin's virus. The results were compared with a third brother, infected by the twins' virus 13 months after their seroconversion. The data show similarity in disease course in persons of identical genetic background infected with the same strain of HIV-1.
• This epitope, AALDMSHFL (AL9), is restricted by HLA-Cw3. Variants that arose were AALDiSHFL and gALDMSHFL.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.