Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 89

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17(76-84)
Epitope	SLYNTVATL	Epitope Alignment
Epitope Name	SL9
Species (MHC/HLA)	human(A*02:01)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords

Notes

• Slow dissociation rate is associated with immunogenicity.
• CTL generated by in vitro stimulation of PBMC derived from uninfected individual.

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.

Displaying record number 423

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HXB2 Location	Pol(263-273) RT(108-118) DNA(2871..2903)	Pol Epitope Map
Author Location	RT(267-277)
Epitope	VLDVGDAYFSV	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords

Notes

• High dissociation rate, but immunogenic in primary CTL induction after repeated stimulations with peptide.
• CTL generated by in vitro stimulation of PBMC derived from uninfected individual.

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.

Displaying record number 519

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT(468-476)
Epitope	ILKEPVHGV	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords

Notes

• Immunogenic in humans, slow dissociation rate, and associated with immunogenicity in transgenic HLA-A*0201/K^b mice.
• CTL generated by in vitro stimulation of PBMC derived from uninfected individual.

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.

Displaying record number 586

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HXB2 Location	Pol(956-964) Integrase(241-249) DNA(4950..4976)	Pol Epitope Map
Author Location	Pol(576-584)
Epitope	LLWKGEGAV	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords

Notes

• Slow dissociation rate, associated with immunogenicity in transgenic HLA-A*0201/K^b mice.
• CTL generated by in vitro stimulation of PBMC derived from uninfected individual.

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.