Search CTL/CD8+ T-Cell Epitope Database

Found 173 matching records:

Displaying record number 56027

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HXB2 Location	Gag(11-19) p17(11-19) DNA(820..846)	Gag Epitope Map
Author Location	p17
Epitope	`GQLDRWEKI`	Epitope Alignment
		Show epitope variants
Epitope Name	GI9(p17)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope GQLDRWEKI elicited an immune response as part of peptide SGGQLDRWEKIRLRPGGK. This epitope differs from the previously described epitope, GELDRWEKI, at 1 residue, GqLDRWEKI.
1 of the 20 HLA-B40 carriers responded to GqLDRWEKI-containing peptide with a magnitude of CTL response of 50 SFC/million PBMC (author communication and Fig.1).

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.

Displaying record number 56422

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HXB2 Location	Gag(18-26) p17(18-26) DNA(841..867)	Gag Epitope Map
Author Location	p17
Epitope	`KIRLRPGGK`	Epitope Alignment
Epitope Name	KK9(p17)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence, SGGQLDRWEKIRLRPGGK, contains the exact sequence of a previously described HLA-A3 optimal epitope, KIRLRPGGK, none of the 3 HLA-A3 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55912

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HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	p17
Epitope	`RLRPGGKKKK`	Epitope Alignment
Epitope Name	RK9(p17)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3-restricted epitope RLRPGGKKKK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EKIRLRPGGKKKKYRLKHL.
2 of the 3 HLA-A3 carriers responded to the RLRPGGKKKK-containing peptide with average magnitude of CTL response of 285 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55913

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HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	p17
Epitope	`RLRPGGKKKKY`	Epitope Alignment
Epitope Name	RK10(p17)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3-restricted epitope RLRPGGKKKKY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EKIRLRPGGKKKKYRLKHL.
2 of the 3 HLA-A3 carriers responded to RLRPGGKKKKY-containing peptide with average magnitude of CTL response of 285 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55928

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HXB2 Location	Gag(28-36) p17(28-36) DNA(871..897)	Gag Epitope Map
Author Location	p17
Epitope	`KYRLKHLVW`	Epitope Alignment
		Show epitope variants
Epitope Name	KW9(p17)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope KYRLKHLVW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GKKKYRLKHLVWASREL. This epitope differs from the previously described HLA-A24-restricted epitope , KYKLKHIVW, at 2 residues, KYrLKHlVW.
6 of the 30 HLA-A24 carriers responded to KYrLKHlVW-containing peptide with average magnitude of CTL response of 179 SFC/million PBMC (author communication and Fig. 1).

References

Displaying record number 55945

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HXB2 Location	Gag(34-44) p17(34-44) DNA(889..921)	Gag Epitope Map
Author Location	p17
Epitope	`LVWASRELERF`	Epitope Alignment
Epitope Name	LF11(p17)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A30-restricted epitope LVWASRELERF elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KHLVWASRELERFAV.
1 of the 15 HLA-A30 carriers responded to LVWASRELERF-containing peptide with a magnitude of CTL response of 260 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56009

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HXB2 Location	Gag(36-44) p17(36-44) DNA(895..921)	Gag Epitope Map
Author Location	p17
Epitope	`WASRELERF`	Epitope Alignment
Epitope Name	WF9(p17)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope WASRELERF elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KHLVWASRELERFAV.
1 of the 12 HLA-B35 carriers responded to WASRELERF-containing peptide with a magnitude of CTL response of 460 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55946

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HXB2 Location	Gag(76-86) p17(76-86) DNA(1015..1047)	Gag Epitope Map
Author Location	p17
Epitope	`RSLFNTVATLY`	Epitope Alignment
		Show epitope variants
Epitope Name	RY11(p17)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RSLFNTVATLY elicited an immune response as part of peptide TGSEELRSLFNTVATLY. This epitope differs from the previously described HLA-A30 and B58-restricted epitope , RSLYNTVATLY, at 1 residue, RSLfNTVATLY.
0 of the 15 HLA-A30 carriers responded to an RSLfNTVATLY-containing peptide and 1 of the 14 HLA-B58 carriers responded to that peptide with average magnitude of CTL response of 170 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55762

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17
Epitope	`SLFNTVATL`	Epitope Alignment
Epitope Name	SL9(p17)
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, optimal epitope, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope SLFNTVATL elicited an immune response as part of peptide TGSEELRSLFNTVATLY. The tested sequence corresponds to previously described HLA-A2-restricted epitope SLYNTVATL, differing from this epitope, SLfNTVATL, at one residue.
11 of the 55 HLA-A2 carriers responded to SLfNTVATL-containing peptide with average magnitude of CTL response of 227 SFC/million PBMC.

References

Displaying record number 55939

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HXB2 Location	Gag(78-86) p17(78-86) DNA(1021..1047)	Gag Epitope Map
Author Location	p17
Epitope	`LFNTVATLY`	Epitope Alignment
		Show epitope variants
Epitope Name	LY9(p17)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope LFNTVATLY elicited an immune response as part of peptides TGSEELRSLFNTVATLY and SLFNTVATLYCVHQRIEI. This epitope differs from the previously described HLA-A29 and -B44-restricted epitope, LYNTVATLY, at 1 residue, LfNTVATLY.
1 of the 8 HLA-A29 carriers responded to LfNTVATLY-containing peptide #11 with a magnitude of CTL response of 415 SFC/million PBMC and 3/8 of the HLA-A29 carriers responded to peptide #12 with average magnitude of CTL response of 95 SFC/million PBMC. 1 of the 6 HLA-B44 carriers responded to peptide #11 with a magnitude of CTL response of 50 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55917

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HXB2 Location	Gag(84-92) p17(84-92) DNA(1039..1065)	Gag Epitope Map
Author Location	p17
Epitope	`TLYCVHQRI`	Epitope Alignment
Epitope Name	TI9(p17)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope TLYCVHQRI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SLFNTVATLYCVHQRI.
4 of the 28 HLA-A11 carriers responded to TLYCVHQRI-containing peptide with average magnitude of CTL response of 145 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56029

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HXB2 Location	Gag(92-101) p17(92-101) DNA(1063..1092)	Gag Epitope Map
Author Location	p17
Epitope	`IEIKDTKEAL`	Epitope Alignment
Epitope Name	IL10(p17)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope IEIKDTKEAL elicited an immune response in Chinese HIV-1 positive subjects as part of peptides LYCVHQRIEIKDTKEAL and IEIKDTKEALEKIEEEQNK.
3 of the 20 HLA-B40 carriers responded to a IEIKDTKEAL-containing peptide with average magnitude of CTL response of 363 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56010

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HXB2 Location	Gag(124-132) p17(124-132) DNA(1159..1185)	Gag Epitope Map
Author Location	p17
Epitope	`NSSQVSQNY`	Epitope Alignment
		Show epitope variants
Epitope Name	NY9(p17)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope NSSQVSQNY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide AADTGNSSQVSQNYPIV. This epitope differs from the previously described HLA-B35-restricted epitope, NSSKVSQNY, at 1 residue, NSSqVSQNY.
2 of the 17 HLA-B35 carriers responded to an NSSqVSQNY-containing peptide with average magnitude of CTL response of 80 SFC/million PBMC.

References

Displaying record number 55964

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HXB2 Location	Gag(127-135) p17(127)-p24(3) DNA(1168..1194)	Gag Epitope Map
Author Location	p17
Epitope	`QVSQNYPIV`	Epitope Alignment
Epitope Name	QV9(p17)
Subtype	B
Species (MHC/HLA)	human(A68)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A68-restricted epitope QVSQNYPIV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SQVSQNYPIVQNLQGQMV.

References

Displaying record number 55984

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HXB2 Location	Gag(135-143) p24(3-11) DNA(1192..1218)	Gag Epitope Map
Author Location	p24
Epitope	`VQNLQGQMV`	Epitope Alignment
Epitope Name	VV9(p24)
Subtype	B
Species (MHC/HLA)	human(B13)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B13-restricted epitope VQNLQGQMV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide IVQNLQGQMVHQPISPR.
7 of the 29 HLA-B13 carriers responded to VQNLQGQMV-containing peptide with average magnitude of CTL response of 189 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55992

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HXB2 Location	Gag(144-152) p24(12-20) DNA(1219..1245)	Gag Epitope Map
Author Location	p24
Epitope	`HQPISPRTL`	Epitope Alignment
		Show epitope variants
Epitope Name	HL9(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope HQPISPRTL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QMVHQPISPRTLNAWVKV. This epitope differs from the previously described HLA-B15-restricted epitope, HQAISPRTL, at 1 residue, HQpISPRTL.
3 of the 21 HLA-B15 carriers responded to HQpISPRTL-containing peptide with average magnitude of CTL response of 750 SFC/million PBMC.

References

Displaying record number 56437

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HXB2 Location	Gag(148-156) p24(16-24) DNA(1231..1257)	Gag Epitope Map
Author Location	p24
Epitope	`SPRTLNAWV`	Epitope Alignment
Epitope Name	SV9(p24)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B7-restricted epitope SPRTLNAWV elicited no immune response in Chinese HIV-1 positive subjects as part of peptide QMVHQPISPRTLNAWVKV.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B7 optimal epitope, SPRTLNAWV, none of the 9 HLA-B7 carriers responded to it.

References

Displaying record number 56452

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HXB2 Location	Gag(156-164) p24(24-32) DNA(1255..1281)	Gag Epitope Map
Author Location	p24
Epitope	`VKVIEEKAF`	Epitope Alignment
Epitope Name	VF9(p24)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, PRTNAWVKVVEEKAF, contains a variant, VKVvEEKAF to the previously described HLA-B15 epitope VKVIEEKAF. None of the 21 HLA-B15 carriers responded to the variant VKVvEEKAF.

References

Displaying record number 56040

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HXB2 Location	Gag(160-168) p24(28-36) DNA(1267..1293)	Gag Epitope Map
Author Location	p24
Epitope	`EEKAFSPEV`	Epitope Alignment
Epitope Name	EV9(p24)
Subtype	B
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B44-restricted epitope EEKAFSPEV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide WVKVVEEKAFSPEVIPMF.
1 of the 6 HLA-B44 carriers responded to EEKAFSPEV-containing peptide with a magnitude of CTL response of 110 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55935

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HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	p24
Epitope	`EVIPMFSAL`	Epitope Alignment
Epitope Name	EL9(p24)
Subtype	B
Species (MHC/HLA)	human(A26)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A26-restricted epitope EVIPMFSAL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide AFSPEVIPMFSALSEGA.
5 of the 8 HLA-A26 carriers responded to EVIPMFSAL-containing peptide with average magnitude of CTL response of 646 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56030

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HXB2 Location	Gag(176-184) p24(44-52) DNA(1315..1341)	Gag Epitope Map
Author Location	p24
Epitope	`SEGATPQDL`	Epitope Alignment
Epitope Name	SL9(p24)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope SEGATPQDL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide PMFSALSEGATPQDLNTM.
4 of the 20 HLA-B40 carriers responded to SEGATPQDL-containing peptide with average magnitude of CTL response of 590 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56456

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	p24
Epitope	`TPQDLNTML`	Epitope Alignment
Epitope Name	TL9(p24)
Subtype	B
Species (MHC/HLA)	human(B39, B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B7- and -B39-restricted epitope, TPQDLNTML, none of the 9 HLA-B7 carriers responded to it (author communication and Fig.1). No information regarding HLA-B39 reactivity is provided.

References

Displaying record number 55993

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HXB2 Location	Gag(193-201) p24(61-69) DNA(1366..1392)	Gag Epitope Map
Author Location	p24
Epitope	`GHQAAMQML`	Epitope Alignment
Epitope Name	GL9(p24)
Subtype	B
Species (MHC/HLA)	human(B15, B39)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope GHQAAMQML elicited an immune response as part of peptide NTMLNTVGGHQAAMQMLK. This epitope is also restricted by HLA-B39 and elicited responses as part of the above peptide and peptide GHQAAMQMLKETINEEAA.
2 of the 21 HLA-B15 carriers responded to GHQAAMQML-containing peptide with average magnitude of CTL response of 105 SFC/million PBMC (author communication and Fig.1). No information regarding HLA-B39 reactivity is provided.

References

Displaying record number 56447

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HXB2 Location	Gag(194-202) p24(62-70) DNA(1369..1395)	Gag Epitope Map
Author Location	p24
Epitope	`HQAAMQMLK`	Epitope Alignment
Epitope Name	HK9(p24)
Subtype	B
Species (MHC/HLA)	human(B52)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B52 optimal epitope, HQAAMQMLK, none of the 5 HLA-B52 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56031

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HXB2 Location	Gag(202-210) p24(70-78) DNA(1393..1419)	Gag Epitope Map
Author Location	p24
Epitope	`KETINEEAA`	Epitope Alignment
Epitope Name	KA9(p24)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope KETINEEAA elicited an immune response in Chinese HIV-1 positive subjects as part of peptides GHQAAMQMLKETINEEAA and LKETINEEAAEWDRLHPV.
5 of the 20 HLA-B40 carriers responded to KETINEEAA-containing peptide #27 with average magnitude of CTL response of 450 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56032

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HXB2 Location	Gag(210-218) p24(78-86) DNA(1417..1443)	Gag Epitope Map
Author Location	p24
Epitope	`AEWDRVHPV`	Epitope Alignment
Epitope Name	AV9(p24)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope AEWDRVHPV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide AAEWDRVHPVHAGPIA.
7 of the 20 HLA-B40 carriers responded to AEWDRVHPV-containing peptide with average magnitude of CTL response of 460 SFC/million PBMC.

References

Displaying record number 56438

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	p24
Epitope	`HPVHAGPIA`	Epitope Alignment
Epitope Name	HA9(p24)
Subtype	B
Species (MHC/HLA)	human(B39, B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B7 and -B39 optimal epitope, HPVHAGPIA, none of the 9 HLA-B7 carriers responded to it (author communication and Fig.1). No information regarding HLA-B39 reactivity is provided.

References

Displaying record number 55985

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HXB2 Location	Gag(226-236) p24(94-104) DNA(1465..1497)	Gag Epitope Map
Author Location	p24
Epitope	`GQMREPRGSDI`	Epitope Alignment
Epitope Name	G11(p24)
Subtype	B
Species (MHC/HLA)	human(B*13)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	optimal epitope, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B13-restricted epitope GQMREPRGSDI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide IAPGQMREPRGSDIA.
10 of the 29 HLA-B13 carriers responded to GQMREPRGSDI-containing peptide with average magnitude of CTL response of 266 SFC/million PBMC.

References

Displaying record number 56051

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	p24
Epitope	`TSTLQEQIGW`	Epitope Alignment
Epitope Name	TW10(p24)
Subtype	B
Species (MHC/HLA)	human(B58)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B58-restricted epitope TSTLQEQIGWF elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SDIAGTTSTLQEQIGWM. This epitope differs from another previously described epitope TSTVEEQQIW, at 3 residues.
4 of the 14 HLA-B58 carriers responded to TSTLqEQigWF-containing peptide with average magnitude of CTL response of 90 SFC/million PBMC.

References

Displaying record number 56011

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HXB2 Location	Gag(254-262) p24(122-130) DNA(1549..1575)	Gag Epitope Map
Author Location	p24
Epitope	`PPIPVGEIY`	Epitope Alignment
		Show epitope variants
Epitope Name	PY9(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope PPIPVGEIY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide WMTNNPPIPVGEIYKRWI. This epitope differs from the previously described HLA-B35-restricted epitope, PPIPVGDIY, at 1 residue, PPIPVGeIY; and from another previously described epitope, NPVPVGNIY, at 3 residues, pPiPVGeIY.
3 of the 12 HLA-B35 carriers responded to PPIPVGeIY-containing peptide with average magnitude of CTL response of 150 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55959

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HXB2 Location	Gag(266-275) p24(134-143) DNA(1585..1614)	Gag Epitope Map
Author Location	p24
Epitope	`IILGLNKIVR`	Epitope Alignment
Epitope Name	IR10(p24)
Subtype	B
Species (MHC/HLA)	human(A33)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	optimal epitope, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A33-restricted epitope IILGLNKIVR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide WIILGLNKIVRMYSPTSI.
2 of the 20 HLA-A33 carriers responded to an IILGLNKIVR-containing peptide with average magnitude of CTL response of 90 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55994

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HXB2 Location	Gag(269-277) p24(137-145) DNA(1594..1620)	Gag Epitope Map
Author Location	p24
Epitope	`GLNKIVRMY`	Epitope Alignment
Epitope Name	GY9(p24)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope GLNKIVRMY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide WIILGLNKIVRMYSPTSI.
5 of the 21 HLA-B15 carriers responded to GLNKIVRMY-containing peptide with average magnitude of CTL response of 204 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56048

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HXB2 Location	Gag(275-282) p24(143-150) DNA(1612..1635)	Gag Epitope Map
Author Location	p24
Epitope	`RMYSPTSI`	Epitope Alignment
Epitope Name	RI8(p24)
Subtype	B
Species (MHC/HLA)	human(B52)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B52-restricted epitope RMYSPTSI elicited an immune response in Chinese HIV-1 positive subjects as peptide WIILGLNKIVRMYSPTSI, but there was no response to peptide IVRMYSPTSILDIRQGPK.
1 of the 5 HLA-B52 carriers responded to RMYSPTSI-containing peptide with a magnitude of CTL response of 250 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55936

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HXB2 Location	Gag(294-304) p24(162-172) DNA(1669..1701)	Gag Epitope Map
Author Location	p24
Epitope	`RDYVDRFYKTL`	Epitope Alignment
		Show epitope variants
Epitope Name	RL11(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RDYVDRFYKTL elicited an immune response as part of peptide GPKEPFRDYVDRFYKTLR. In HLA-A24, -A26 and -B44 carriers, this epitope differs from the previously described epitope , RDYVDRFFKTL, at 1 residue, RDYVDRFyKTL.
5 of the 30 HLA-A24 carriers responded to RDYVDRFyKTL-containing peptide with average magnitude of CTL response of 182 SFC/million PBMC; 3 of the 8 HLA-A26 carriers responded with an average magnitude of CTL response of 333 SFC/million PBMC; 1 of the 6 HLA-B44 carriers responded with a magnitude of CTL response of 80 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55899

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HXB2 Location	Gag(296-304) p24(164-172) DNA(1675..1701)	Gag Epitope Map
Author Location	p24
Epitope	`YVDRFYKTL`	Epitope Alignment
		Show epitope variants
Epitope Name	YL9(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described epitope YVDRFYKTL elicited an immune response as part of peptide YVDRFYKTLRAEQASQEV as well as peptides GPKEPFRDYVDRFYKTLR and YYVDRFYKTLRAEQASQEV. This epitope differs from the previously described HLA-A2 and B15-restricted epitope, YVDRFFKTL, at 1 residue, YVDRFyKTL.
18 of the 55 HLA-A2 carriers responded to a YVDRFyKTL-containing peptide with average magnitude of CTL response of 334 SFC/million PBMC; 9 of the 21 HLA-B15 carriers responded to a YVDRFyKTL-containing peptide with average magnitude of CTL response of 542 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56042

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HXB2 Location	Gag(306-316) p24(174-184) DNA(1705..1737)	Gag Epitope Map
Author Location	p24
Epitope	`AEQASQEVKNW`	Epitope Alignment
		Show epitope variants
Epitope Name	AW11(p24)
Subtype	B
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope AEQASQEVKNW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LRAEQASQEVKNWMTETL. This epitope differs from the previously described HLA-B44-restricted epitope, AEQASQDVKNW, at 1 residue, AEQASQeVKNW.
2 of the 6 HLA-B44 carriers responded to AEQASQeVKNW-containing peptide with average magnitude of CTL response of 190 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55919

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HXB2 Location	Gag(349-359) p24(217-227) DNA(1834..1866)	Gag Epitope Map
Author Location	p24
Epitope	`ACQGVGGPSHK`	Epitope Alignment
		Show epitope variants
Epitope Name	AK11(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope ACQGVGGPSHK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ACQGVGGPSHKARVLAEA. This epitope differs from the previously described HLA-A11-restricted epitope sequence, ACQGVGGPGHK, at 1 residue, ACQGVGGPsHK.
3 of the 28 HLA-A11 carriers responded to ACQGVGGPsHK-containing peptide with average magnitude of CTL response of 145 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55918

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HXB2 Location	Gag(352-359) p24(220-227) DNA(1843..1866)	Gag Epitope Map
Author Location	p24
Epitope	`GVGGPSHK`	Epitope Alignment
		Show epitope variants
Epitope Name	GK8(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope GVGGPSHK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide AATLEEMMTACQGVGGPSH. This epitope differs from the previously described HLA-A11-restricted epitope, GVGGPSGK, at 1 residue, GVGGPsHK.
6 of the 28 HLA-A11 carriers responded to GVGGPsHK-containing peptide with average magnitude of CTL response of 345 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55972

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HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location	p24
Epitope	`GPSHKARVL`	Epitope Alignment
		Show epitope variants
Epitope Name	GL9(p24)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope GPSHKARVL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ACQGVGGPSHKARVLAEA. This epitope differs from the previously described HLA-B7-restricted epitope, GPGHKARVL, at 1 residue, GPsHKARVL.
1 of the 9 HLA-B7 carriers responded to GPsHKARVL-containing peptide with average magnitude of CTL response of 870 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56033

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HXB2 Location	Gag(427-434) p2p7p1p6(64-71) DNA(2068..2091)	Gag Epitope Map
Author Location	p2p7p1p6
Epitope	`TERQANFL`	Epitope Alignment
Epitope Name	TL8(p2p7p1p6)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope TERQANFL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QMKDCTERQANFLGKIW.
5 of the 20 HLA-B40 carriers responded to TERQANFL-containing peptide with average magnitude of CTL response of 361 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55986

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HXB2 Location	Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100)	Gag Epitope Map
Author Location	p2p7p1p6
Epitope	`RQANFLGKI`	Epitope Alignment
Epitope Name	RI9(p2p7p1p6)
Subtype	B
Species (MHC/HLA)	human(B13)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B13-restricted epitope RQANFLGKI elicited an immune response in Chinese HIV-1 positive subjects as part of peptides QMKDCTERQANFLGKIW and RQANFLGKIWPSHKGR.
9 of the 29 HLA-B13 carriers responded to RQANFLGKI-containing peptide #59 with average magnitude of CTL response of 342 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55900

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HXB2 Location	Gag(433-442) p2p7p1p6(70-79) DNA(2086..2115)	Gag Epitope Map
Author Location	p2p7p1p6
Epitope	`FLGKIWPSHK`	Epitope Alignment
Epitope Name	FK10(p2p7p1p6)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope FLGKIWPSHK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide RQANFLGKIWPSHKGR. This epitope differs from the previously described HLA-B7-restricted epitope, FLGKIWPSYK, at 1 residue, FLGKIWPShK.
11 of the 55 HLA-A2 carriers responded to FLGKIWPShK-containing peptide with average magnitude of CTL response of 188 SFC/million PBMC.

References

Displaying record number 56034

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HXB2 Location	Gag(481-489) p2p7p1p6(118-126) DNA(2230..2256)	Gag Epitope Map
Author Location	p2p7p1p6
Epitope	`KELYPLTSL`	Epitope Alignment
		Show epitope variants
Epitope Name	KL9(p2p7p1p6)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope KELYPLASL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide as part of peptides QKQEPIDKELYPLASLK and KELYPLASLKSLFGNDPS. This epitope differs from the previously described HLA-B40-restricted epitope, KELYPLTSL, at 1 residue, KELYPLaSL.
5 of the 20 HLA-B40 carriers responded to KELYPLaSL-containing peptide #65 with average magnitude of CTL response of 462 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55967

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HXB2 Location	Pol(59-67) Protease(3-11) DNA(2259..2285)	Pol Epitope Map
Author Location	Protease
Epitope	`ITLWQRPLV`	Epitope Alignment
Epitope Name	IV9(Protease)
Subtype	B
Species (MHC/HLA)	human(A68)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A68-restricted epitope ITLWQRPLV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SFSFPQITLWQRPLVTIK.

References

Displaying record number 55968

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HXB2 Location	Pol(86-94) Protease(30-38) DNA(2340..2366)	Pol Epitope Map
Author Location	Protease
Epitope	`DTVLEDMNL`	Epitope Alignment
		Show epitope variants
Epitope Name	DL9(Protease)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope DTVLEDMNL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide as part of peptide GADDTVLEDMNLPGRWK. This epitope differs from the previously described HLA-A68-restricted epitope, DTVLEEWNL, at 2 residues, DTVLEdmNL.

References

Displaying record number 56043

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HXB2 Location	Pol(90-98) Protease(34-42) DNA(2352..2378)	Pol Epitope Map
Author Location	Protease
Epitope	`EDMNLPGRW`	Epitope Alignment
		Show epitope variants
Epitope Name	EW9(Protease)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope EDMNLPGRW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GADDTVLEDMNLPGRWK. This epitope differs from the previously described HLA-B44-restricted epitope, EEMNLPGRW, at 1 residue, EdMNLPGRW.
1 of the 6 HLA-B44 carriers responded to EdMNLPGRW-containing peptide with average magnitude of CTL response of 300 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55989

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HXB2 Location	Pol(113-122) Protease(57-66) DNA(2421..2450)	Pol Epitope Map
Author Location	Protease
Epitope	`RQYDQIPIEI`	Epitope Alignment
		Show epitope variants
Epitope Name	RI10(Protease)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RQYDQIPIEI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KVRQYDQIPIEICGHKAI. This epitope differs from the previously described HLA-B13-restricted epitope sequence, RQYDQILIEI, at 1 residue, RQYDQIpIEI.
2 of the 29 HLA-B13 carriers responded to RQYDQIpIEI-containing peptide with average magnitude of CTL response of 160 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56000

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HXB2 Location	Pol(124-132) Protease(68-76) DNA(2454..2480)	Pol Epitope Map
Author Location	Protease
Epitope	`GKKAIGTVL`	Epitope Alignment
		Show epitope variants
Epitope Name	GL9(Protease)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
GHKAIGTVL elicited an immune response in Chinese HIV-1 positive subjects as peptide PIEICGHKAIGTVL. None of the 21 HLA-B15 carriers responded to peptide GHKAIGTVLVGPTPVNII. These peptide-contained epitopes differ from the previously described HLA-B15-restricted epitope, GkKAIGTVL by 1 residue.

References

Displaying record number 55904

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HXB2 Location	Pol(132-140) Protease(76-84) DNA(2478..2504)	Pol Epitope Map
Author Location	Protease
Epitope	`LVGPTPVNI`	Epitope Alignment
Epitope Name	LI9(Proteasee)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A2-restricted epitope LVGPTPVNI elicited an immune response in Chinese HIV-1 positive subjects as part of peptides GHKAIGTVLVGPTPVNII and LVGPTPVNIIGRNLLTQL.
8 of the 55 HLA-A2 carriers responded to LVGPTPVNI-containing peptide with average magnitude of CTL response of 213 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56036

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HXB2 Location	Pol(160-167) RT(5-12) DNA(2562..2585)	Pol Epitope Map
Author Location	RT
Epitope	`IETVPVKL`	Epitope Alignment
Epitope Name	IL8(RT)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope IETVPVKL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide PISPIETVPVKLKPGM.
5 of the 20 HLA-B40 carriers responded to a IETVPVKL-containing peptide with average magnitude of CTL response of 664 SFC/million PBMC.

References

Displaying record number 56420

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HXB2 Location	Pol(188-196) RT(33-41) DNA(2646..2672)	Pol Epitope Map
Author Location	RT
Epitope	`ALVEICTEM`	Epitope Alignment
Epitope Name	AM9(RT)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-A2 optimal epitope, ALVEICTEM, none of the 55 HLA-A2 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56423

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HXB2 Location	Pol(188-198) RT(33-43) DNA(2646..2678)	Pol Epitope Map
Author Location	RT
Epitope	`ALVEICTEMEK`	Epitope Alignment
Epitope Name	AK11(RT)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3-restricted epitope ALVEICTEMEK elicited no immune response in Chinese HIV-1 positive subjects as part of peptide EEKIKALVEICTEMEK.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-A3 optimal epitope, ALVEICTEMEK, none of the 3 HLA-A3 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56444

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HXB2 Location	Pol(197-205) RT(42-50) DNA(2673..2699)	Pol Epitope Map
Author Location	RT
Epitope	`EKEGKISKI`	Epitope Alignment
Epitope Name	EI9(RT)
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B51 optimal epitope, EKEGKISKI, none of the 15 HLA-B51 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56424

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HXB2 Location	Pol(228-237) RT(73-82) DNA(2766..2795)	Pol Epitope Map
Author Location	RT
Epitope	`KLVDFRELNK`	Epitope Alignment
Epitope Name	KK10(RT)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-A3 optimal epitope, KLVDFRELNK, none of the 3 HLA-A3 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56425

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HXB2 Location	Pol(248-256) RT(93-101) DNA(2826..2852)	Pol Epitope Map
Author Location	RT
Epitope	`GIPHPAGLK`	Epitope Alignment
Epitope Name	GK9(RT)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-A3 optimal epitope, GIPHPAGLK, none of the 3 HLA-A3 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56014

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HXB2 Location	Pol(262-270) RT(107-115) DNA(2868..2894)	Pol Epitope Map
Author Location	RT
Epitope	`TVLDVGDAY`	Epitope Alignment
Epitope Name	TY9(RT)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope TVLDVGDAY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KKKSVTVLDVGDAYFSV.
5 of the 12 HLA-B35 carriers responded to a TVLDVGDAY-containing peptide with average magnitude of CTL response of 604 SFC/million PBMC.

References

Displaying record number 56015

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HXB2 Location	Pol(273-282) RT(118-127) DNA(2901..2930)	Pol Epitope Map
Author Location	RT
Epitope	`VPLDKDFRKY`	Epitope Alignment
		Show epitope variants
Epitope Name	VY10(RT)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope VPLDKDFRKY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SVPLDKDFRKYTAFTI. This epitope differs from the previously described HLA-B35-restricted epitope, VPLDEDFRKY, at 1 residue, VPLDkDFRKY.
2 of the 12 HLA-B35 carriers responded to VPLDkDFRKY-containing peptide with average magnitude of CTL response of 210 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55905

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HXB2 Location	Pol(282-290) RT(127-135) DNA(2928..2954)	Pol Epitope Map
Author Location	RT
Epitope	`YTAFTIPSI`	Epitope Alignment
Epitope Name	YI9(RT)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A2-restricted epitope YTAFTIPSI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide DFRKYTAFTIPSINNETPGI.
4 of the 55 HLA-A2 carriers responded to YTAFTIPSI-containing peptide with average magnitude of CTL response of 140 SFC/million PBMC.

References

Displaying record number 56045

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	RT
Epitope	`TAFTIPSI`	Epitope Alignment
Epitope Name	TI8(RT)
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B51-restricted epitope TAFTIPSI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide DRFKYTAFTIPSINNETPGI.
3 of the 15 HLA-B51 carriers responded to TAFTIPSI-containing peptide with average magnitude of CTL response of 173 SFC/million PBMC.

References

Displaying record number 55980

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HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	RT
Epitope	`SPAIFQSSM`	Epitope Alignment
Epitope Name	SM9(RT)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, QGWKGSPAIFQCSMTKIL, contains a variant, SPAIFQcSM, that differs by 1 substitution from the previously described HLA-B7 epitope SPAIFQSSM. None of the 16 HLA-B7 carriers responded to a variant SPAIFQcSM.

References

Displaying record number 56458

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	RT
Epitope	`AIFQCSMTK`	Epitope Alignment
		Show epitope variants
Epitope Name	AK9(RT)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, QGWKGSPAIFQcSMTKIL, contains a variant, AIFQcSMTK that differs by 1 substitution from the previously described HLA-A3 and HLA-A11 previously described epitope AIFQSSMTK.
None of the 3 HLA-A3 carriers responded to peptide epitope AIFQcSMTK. 4 of the 16 HLA-A11 carriers responded with average magnitude of CTL response of 183 SFC/million PBMC.

References

Displaying record number 56433

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HXB2 Location	Pol(328-336) RT(173-181) DNA(3066..3092)	Pol Epitope Map
Author Location	RT
Epitope	`KQNPDIVIY`	Epitope Alignment
Epitope Name	KY9(RT)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequences, MTKILEPFRKQNPDIVIY and RKQNPDIVIYQYMDDLYV, contain the exact sequence of a previously described HLA-A30 epitope, KQNPDIVIY, none of the 15 HLA-A30 carriers responded to it.

References

Displaying record number 56016

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HXB2 Location	Pol(330-338) RT(175-183) DNA(3072..3098)	Pol Epitope Map
Author Location	RT
Epitope	`NPDIVIYQY`	Epitope Alignment
Epitope Name	NY9(RT)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope NPDIVIYQY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide RKQNPDIVIYQYMDDLYV. This epitope differs from another described epitope, HPDIVIYQY, at 1 residue, nPDIVIYQY.
5 of the 12 HLA-B35 carriers responded to NPDIVIYQY-containing peptide with average magnitude of CTL response of 662 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55906

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HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	RT
Epitope	`VIYQYMDDL`	Epitope Alignment
Epitope Name	VL9(RT)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously desctibedHLA-A2-restricted epitope VIYQYMDDL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide RKQNPDIVIYQYMDDLYV.
4 of the 55 HLA-A2 carriers responded to VIYQYMDDL-containing peptide with average magnitude of CTL response of 252 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56037

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HXB2 Location	Pol(357-365) RT(202-210) DNA(3153..3179)	Pol Epitope Map
Author Location	RT
Epitope	`IEELRQHLL`	Epitope Alignment
Epitope Name	IL9(RT)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope IEELRQHLL elicited an immune response in Chinese HIV-1 positive subjects as part of peptides LEIGQHRTKIEELRQHLL and KIEELRQHLLRWGFTTPDK.
5 of the 20 HLA-B40 carriers responded to IEELRQHLL-containing peptide #193 with average magnitude of CTL response of 716 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56001

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HXB2 Location	Pol(415-426) RT(260-271) DNA(3327..3362)	Pol Epitope Map
Author Location	RT
Epitope	`LVGKLNWASQIY`	Epitope Alignment
Epitope Name	LY12(RT)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope LVGKLNWASQIY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide NDIQKLVGKLNWASQIYA.
4 of the 21 HLA-B15 carriers responded to LVGKLNWASQIY-containing peptide with average magnitude of CTL response of 350 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55947

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HXB2 Location	Pol(418-426) RT(263-271) DNA(3336..3362)	Pol Epitope Map
Author Location	RT
Epitope	`KLNWASQIY`	Epitope Alignment
Epitope Name	KY9(RT)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A30-restricted epitope KLNWASQIY elicited an immune response in Chinese HIV-1 positive subjects as peptide NDIQKLVGKLNWASQIYA but not as peptide KLNWASQIYAGIKVKQL.
1 of the 15 HLA-A30 carriers responded to KLNWASQIY-containing peptide #201 with average magnitude of CTL response of 40 SFC/million PBMC. Although the second tested peptide #202 contains the exact sequence of a previously described HLA-A30 optimal epitope, KLNWASQIY, none of the 15 HLA-A30 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55926

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HXB2 Location	Pol(424-432) RT(269-277) DNA(3354..3380)	Pol Epitope Map
Author Location	RT
Epitope	`QIYAGIKVK`	Epitope Alignment
Epitope Name	QK9(RT)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope QIYAGIKVK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KLNWASQIYAGIKVKQL.
3 of the 28 HLA-A11 carriers responded to QIYAGIKVK-containing peptide with average magnitude of CTL response of 53 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56459

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HXB2 Location	Pol(424-432) RT(269-277) DNA(3354..3380)	Pol Epitope Map
Author Location	RT
Epitope	`QIYPGIKVR`	Epitope Alignment
Epitope Name	QR9(RT)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, KLNWASQIYaGIKVkQL, contains a variant, QIYaGIKVk that differs by 2 substitutions from the previously described HLA-A3 epitope QIYPGIKVR. None of the 18 HLA-A3 carriers responded to the variant QIYaGIKVk.

References

Displaying record number 55907

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT
Epitope	`ILKEPVHGV`	Epitope Alignment
Epitope Name	IV9(RT)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A2-restricted epitope ILKEPVHGV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ELAENREILKEPVHGVYY.
5 of the 55 HLA-A2 carriers responded to ILKEPVHGV-containing peptide with average magnitude of CTL response of 189 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56002

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HXB2 Location	Pol(464-473) RT(309-318) DNA(3474..3503)	Pol Epitope Map
Author Location	RT
Epitope	`ILKEPVHGVY`	Epitope Alignment
Epitope Name	IY10(RT)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope ILKEPVHGVY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ELAENREILKEPVHGVYY.
4 of the 21 HLA-B15 carriers responded to ILKEPVHGVY-containing peptide with average magnitude of CTL response of 410 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55990

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HXB2 Location	Pol(488-496) RT(333-341) DNA(3546..3572)	Pol Epitope Map
Author Location	RT
Epitope	`GQGQWTYQI`	Epitope Alignment
Epitope Name	GI9(RT)
Subtype	B
Species (MHC/HLA)	human(B13)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B13-restricted epitope GQGQWTYQI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GQGQWTYQIYQEPFKNLK.
>2 of the 29 HLA-B13 carriers responded to GQGQWTYQI-containing peptide with average magnitude of CTL response of 160 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55924

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HXB2 Location	Pol(496-505) RT(341-350) DNA(3570..3599)	Pol Epitope Map
Author Location	RT
Epitope	`IYQEPFKNLK`	Epitope Alignment
Epitope Name	IK10(RT)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope IYQEPFKNLK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GQGQWTYQIYQEPFKNLK.
6 of the 28 HLA-A11 carriers responded to IYQEPFKNLK-containing peptide with average magnitude of CTL response of 316 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55948

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HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	RT
Epitope	`RMRGAHTNDV`	Epitope Alignment
Epitope Name	RV10(RT)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A30-restricted epitope RMRGAHTNDV elicited an immune response in Chinese HIV-1 positive subjects LKTGKYARMRGAHTNDVK.
1 of the 15 HLA-A30 carriers responded to RMRGAHTNDV-containing peptide with average magnitude of CTL response of 90 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56426

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HXB2 Location	Pol(511-521) RT(356-366) DNA(3615..3647)	Pol Epitope Map
Author Location	RT
Epitope	`RMRGAHTNDVK`	Epitope Alignment
Epitope Name	RK11(RT)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3-restricted epitope RMRGAHTNDVK elicited no immune response in Chinese HIV-1 positive subjects as part of peptide LKTGKYARMRGAHTNDVK.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-A3 optimal epitope, RMRGAHTNDVK, none of the 3 HLA-A3 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56053

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HXB2 Location	Pol(530-538) RT(375-383) DNA(3672..3698)	Pol Epitope Map
Author Location	RT
Epitope	`IATESIVIW`	Epitope Alignment
		Show epitope variants
Epitope Name	IW9(RT)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
IATESIVIW, elicited an immune response in Chinese HIV-1 positive subjects as a part of peptide QKIATESIVIWGKTPKFK. This epitope differs from the previously described HLA-B58-restricted epitope IAMESIVIW, at 1 residue, IAtESIVIW.
8 of the 14 HLA-B58 carriers responded to IAtESIVIW-containing peptide with average magnitude of CTL response of 455 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55955

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HXB2 Location	Pol(547-556) RT(392-401) DNA(3723..3752)	Pol Epitope Map
Author Location	RT
Epitope	`PIQKETWEAW`	Epitope Alignment
		Show epitope variants
Epitope Name	PW10(RT)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope PIQKETWEAW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide FKLPIQKETWEAWWTEYW. This epitope differs from the previously described HLA-A32-restricted epitope, PIQKETWETW, at 1 residue, PIQKETWEaW.

References

Displaying record number 55966

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HXB2 Location	Pol(591-600) RT(436-445) DNA(3855..3884)	Pol Epitope Map
Author Location	RT
Epitope	`GAETFYVDGA`	Epitope Alignment
Epitope Name	GA10(RT)
Subtype	B
Species (MHC/HLA)	human(A68)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A68-restricted epitope GAETFYVDGA elicited an immune response in Chinese HIV-1 positive subjects as part of peptides QLEKEPIEGAETFYVDGA and GAETFYVDGAANRETKL.

References

Displaying record number 55937

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HXB2 Location	Pol(593-603) RT(438-448) DNA(3861..3893)	Pol Epitope Map
Author Location	RT
Epitope	`ETFYVDGAANR`	Epitope Alignment
Epitope Name	ER11(RT)
Subtype	B
Species (MHC/HLA)	human(A26)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A26-restricted epitope ETFYVDGAANR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GAETFYVDGAANRETKL.
1 of the 8 HLA-A26 carriers responded to ETFYVDGAANR-containing peptide with a magnitude of CTL response of 220 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55938

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HXB2 Location	Pol(604-612) RT(449-457) DNA(3894..3920)	Pol Epitope Map
Author Location	RT
Epitope	`ETKLGKAGY`	Epitope Alignment
Epitope Name	EY9(RT)
Subtype	B
Species (MHC/HLA)	human(A26)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A26-restricted epitope ETKLGKAGY elicited an immune response in Chinese HIV-1 positive subjects as part of peptides DGAANRETKLGKAGYV and ETKLGKAGYVTNKGRQKV.
2 of the 8 HLA-A26 carriers responded to ETKLGKAGY-containing peptide #225 with average magnitude of CTL response of 380 SFC/million PBMC, and to peptide #226 with average magnitude of CTL response of 575 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56441

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HXB2 Location	Pol(651-660) RT(496-505) DNA(4035..4064)	Pol Epitope Map
Author Location	RT
Epitope	`VTDSQYALGI`	Epitope Alignment
Epitope Name	VI10(RT)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B15 optimal epitope, VTDSQYALGI, none of the 21 HLA-B15 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55925

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HXB2 Location	Pol(675-683) RT(520-528) DNA(4107..4133)	Pol Epitope Map
Author Location	RT
Epitope	`QIIEQLIKK`	Epitope Alignment
Epitope Name	QK9(RT)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope ELVSQIIEQLIKKEKVYL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QIIEQLIKK.
2 of the 28 HLA-A11 carriers responded to QIIEQLIKK-containing peptide with average magnitude of CTL response of 75 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56046

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HXB2 Location	Pol(743-751) Integrase(28-36) DNA(4311..4337)	Pol Epitope Map
Author Location	Integrase
Epitope	`LPPVVAKEI`	Epitope Alignment
Epitope Name	LI9(Integrase)
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B51-restricted epitope LPPVVAKEI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide MASDFNLPPVVAKEIVA.
1 of the 15 HLA-B51 carriers responded to LPPVVAKEI-containing peptide with a magnitude of CTL response of 40 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56003

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HXB2 Location	Pol(781-789) Integrase(66-74) DNA(4425..4451)	Pol Epitope Map
Author Location	Integrase
Epitope	`THLEGKIIL`	Epitope Alignment
Epitope Name	TL9(Integrase)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope THLEGKIIL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GIWQLDCTHLEGKIILVA.
1 of the 21 HLA-B15 carriers responded to THLEGKIIL-containing peptide with average magnitude of CTL response of 50 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56453

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HXB2 Location	Pol(850-858) Integrase(135-143) DNA(4632..4658)	Pol Epitope Map
Author Location	Integrase
Epitope	`IQQEFGIPY`	Epitope Alignment
Epitope Name	IY9(Integrase)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	enhancing activity, non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequences, KAACWWAGIKQEFGIPY and GIKQEFGIPYNPQSQGVV, contain a variant, IkQEFGIPY that differs by 1 substitution from the previously described HLA-B15 epitope IQQEFGIPY. None of the 21 HLA-B15 carriers responded to the variant IkQEFGIPY.

References

Displaying record number 56427

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HXB2 Location	Pol(894-903) Integrase(179-188) DNA(4764..4793)	Pol Epitope Map
Author Location	Integrase
Epitope	`AVFIHNFKRK`	Epitope Alignment
Epitope Name	AK10(Integrase)
Subtype	B
Species (MHC/HLA)	human(A11, A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence LKTAVQMAVFIHNFKRK contains the exact sequence of a previously described HLA-A3 optimal epitope, AVFIHNFKRK, none of the 3 HLA-A3 carriers responded to it. 4 of the 28 HLA-A11 carriers responded to the AVFIHNFKRK-containing peptide AVFIHNFKRKGGIGGYSA with average magnitude of CTL response of 150 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56442

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HXB2 Location	Pol(900-909) Integrase(185-194) DNA(4782..4811)	Pol Epitope Map
Author Location	Integrase
Epitope	`FKRKGGIGGY`	Epitope Alignment
Epitope Name	FY10(Integrase)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B15 optimal epitope, FKRKGGIGGY, none of the 21 HLA-B15 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55949

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HXB2 Location	Pol(934-942) Integrase(219-227) DNA(4884..4910)	Pol Epitope Map
Author Location	Integrase
Epitope	`KIQNFRVYY`	Epitope Alignment
Epitope Name	KY9(Integrase)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the peptides tested, FKIQNFRVYYRDSRDPLW and TKELQKQITKIQNFRVYY, contained the exact sequence of a previously described HLA-A30 epitope, KIQNFRVYY, none of the 15 HLA-A30 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56004

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HXB2 Location	Pol(978-986) Integrase(263-271) DNA(5016..5042)	Pol Epitope Map
Author Location	Integrase
Epitope	`RKAKIIRDY`	Epitope Alignment
Epitope Name	RY9(Integrase)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope RKAKIIRDY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KVVPRRKAKIIRDYGKQM.
1 of the 21 HLA-B15 carriers responded to RKAKIIRDY-containing peptide with a magnitude of CTL response of 1,150 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56429

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HXB2 Location	Vif(17-26) DNA(5089..5118)	Vif Epitope Map
Author Location	Vif
Epitope	`RIRTWKSLVK`	Epitope Alignment
Epitope Name	RK10(Vif)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptides (IVWQVDRMRIRTWKSLVK and RIRTWKSLVKHHMYISKK) contained the exact sequence of a previously described HLA-A3 optimal epitope, RIRTWKSLVK, none of the 3 HLA-A3 carriers responded to it.

References

Displaying record number 55916

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HXB2 Location	Vif(28-36) DNA(5122..5148)	Vif Epitope Map
Author Location	Vif
Epitope	`HMYISKKAK`	Epitope Alignment
Epitope Name	HK9(Vif)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3-restricted epitope HMYISKKAK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide VKHHMYISKKAKGWLYKH.
1 of the 3 HLA-A3 carriers responded to HMYISKKAK-containing peptidewith a magnitude of CTL response of 70 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55983

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HXB2 Location	Vif(48-57) DNA(5182..5211)	Vif Epitope Map
Author Location	Vif
Epitope	`HPKISSEVHI`	Epitope Alignment
Epitope Name	HI10(Vif)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B7-restricted epitope HPKISSEVHI elicited an immune response in Chinese HIV-1 positive subjects as part of peptides KHHYDSTHPKISSEVHI and HPKISSEVHIPLGDARLV.
1 of the 9 HLA-B7 carriers responded to an HPKISSEVHI-containing peptide with a magnitude of CTL response of 140 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56450

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HXB2 Location	Vif(57-66) DNA(5209..5238)	Vif Epitope Map
Author Location	Vif
Epitope	`IPLGDAKLII`	Epitope Alignment
Epitope Name	II10(Vif)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, HIPLGDArLvITTYWGLH, contains a variant, IPLGDArLvI that differs by 2 substitutions from the previously described HLA-B51 epitope IPLGDAKLII. None of the 15 HLA-B51 carriers responded to the variant IPLGDArLvI.

References

Displaying record number 56008

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HXB2 Location	Vif(79-87) DNA(5275..5301)	Vif Epitope Map
Author Location	Vif
Epitope	`WHLGHVSI`	Epitope Alignment
Epitope Name	WI8(Vif)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence, LHTGERDWHLGQGVSIEW, contains the exact sequence of a previously described HLA-B15 epitope, WHLGHVSI, none of the 21 HLA-B15 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56023

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HXB2 Location	Vif(79-87) DNA(5275..5301)	Vif Epitope Map
Author Location	Vif
Epitope	`WHLGQGVSI`	Epitope Alignment
Epitope Name	WI9(Vif)
Subtype	B
Species (MHC/HLA)	human(B*38)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B38-restricted epitope WHLGQGVSI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LHTGERDWHLGQGVSIEW.

References

Displaying record number 56457

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HXB2 Location	Vif(158-168) DNA(5512..5544)	Vif Epitope Map
Author Location	Vif
Epitope	`KTKPPLPSVKK`	Epitope Alignment
Epitope Name	KK11(Vif)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, TALTTPKkIKPPLPSVrK, contains a variant, KiKPPLPSVrK that differs by 2 substitutions from the previously described HLA-A3 epitope KTKPPLPSVKK. None of the 3 HLA-A3 carriers responded to the variant KiKPPLPSVrK.

References

Displaying record number 56038

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HXB2 Location	Vpr(12-20) DNA(5592..5618)	Vpr Epitope Map
Author Location	Vpr
Epitope	`REPYNEWTL`	Epitope Alignment
		Show epitope variants
Epitope Name	RL9(Vpr)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope REPYNEWTL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GPQREPYNEWTLELLEEL. This epitope differs from the previously described HLA-B40-restricted epitope sequence, REPHNEWTL, at 1 residue, REPyNEWTL.
4 of the 20 HLA-B40 carriers responded to REPyNEWTL-containing peptide with average magnitude of CTL response of 705 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56451

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HXB2 Location	Vpr(29-37) DNA(5643..5669)	Vpr Epitope Map
Author Location	Vpr
Epitope	`EAVRHFPRI`	Epitope Alignment
Epitope Name	EI9(Vpr)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, ELKREAVRHFPRpWLHGL, contains a variant, EAVRHFPRp that differs by 2 substitutions from the previously described HLA-B51 epitope EAVRHFPRI. None of the 15 HLA-B51 carriers responded to the variant EAVRHFPRp.

References

Displaying record number 55981

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HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location	Vpr
Epitope	`FPRPWLHGL`	Epitope Alignment
		Show epitope variants
Epitope Name	FL9(Vpr)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope FPRPWLHGL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide HFPRPWLHGLGQHIYETY. This epitope differs from the previously described HLA-B7-restricted epitope, FPRIWLHGL, at 1 residue, FPRpWLHGL.
1 of the 9 HLA-B7 carriers responded to an FPRpWLHGL-containing peptide with a magnitude of CTL response of 100 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55969

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HXB2 Location	Vpr(48-57) DNA(5700..5729)	Vpr Epitope Map
Author Location	Vpr
Epitope	`ETYGDTWAGV`	Epitope Alignment
		Show epitope variants
Epitope Name	EV10(Vpr)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope ETYGDTWAGV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GLGQHIYETYGDTWAGV. This epitope differs from the previously described HLA-A68-restricted epitope, ETYGDTWTGV, at 1 residue, ETYGDTWaGV.

References

Displaying record number 55970

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HXB2 Location	Vpr(52-62) DNA(5712..5744)	Vpr Epitope Map
Author Location	Vpr
Epitope	`DTWAGVEAIIR`	Epitope Alignment
Epitope Name	DR11(Vpr)
Subtype	B
Species (MHC/HLA)	human(A68)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A68-restricted epitope DTWAGVEAIIR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ETYGDTWAGVEAIIRIL.

References

Displaying record number 55908

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HXB2 Location	Vpr(59-67) DNA(5733..5759)	Vpr Epitope Map
Author Location	Vpr
Epitope	`AIIRILQQL`	Epitope Alignment
Epitope Name	AL9(Vpr)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A2-restricted epitope AIIRILQQL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide AGVEAIIRILQQLFIHF.
1 of the 55 HLA-A2 carriers responded to AIIRILQQL-containing peptide with a magnitude of CTL response of 130 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56449

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HXB2 Location	Tat(2-11) DNA(5834..5863)	Tat Epitope Map
Author Location	Tat
Epitope	`EPVDPNLEPW`	Epitope Alignment
Epitope Name	EW10(Tat)
Subtype	B
Species (MHC/HLA)	human(B58)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence contains the exact sequence of a previously described HLA-B58 optimal epitope, EPVDPNLEPW, as part of peptide MEPVDPNLEPWKHPGSQPK, none of the 14 HLA-B58 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55999

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HXB2 Location	Tat(38-47) DNA(5942..5971)	Tat Epitope Map
Author Location	Tat
Epitope	`FMKKGLGISY`	Epitope Alignment
		Show epitope variants
Epitope Name	FY10(Tat)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope FMKKGLGISY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide as part of peptide LHCQVCFMKKGLGISYGR. This epitope differs from the previously described HLA-B15-restricted epitope , FQTKGLGISY, at 2 residues, FmkKGLGISY.
1 of the 21 HLA-B15 carriers responded to FmkKGLGISY-containing peptide with a magnitude of CTL response of 100 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55965

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HXB2 Location	Tat(39-49) DNA(5945..5977)	Tat Epitope Map
Author Location	Tat
Epitope	`MKKGLGISYGR`	Epitope Alignment
		Show epitope variants
Epitope Name	IR11(Tat)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope MKKGLGISYGR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LHCQVCFMKKGLGISYGR. This epitope differs from the previously described HLA-A68-restricted epitope, ITKGLGISYGR, at 2 residues, mkKGLGISYGR.

References

Displaying record number 56052

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HXB2 Location	Rev(14-23) DNA(6009..6038)	Rev Epitope Map
Author Location	Rev
Epitope	`RTVRLIKLLY`	Epitope Alignment
		Show epitope variants
Epitope Name	KY10(Rev)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RTVRLIKLLY elicited an immune response in Chinese HIV-1 positive subjects as a part of peptide DEELLRTVRLIKLLY. This epitope differs from the previously described HLA-B58-restricted epitope, KAVRLIKFLY, at 3 residues, rtVRLIKlLY.
6 of the 14 HLA-B58 carriers responded to rtVRLIKlLY-containing peptide with average magnitude of CTL response of 290 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56461

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HXB2 Location	Rev(55-64) DNA(8465..8494)	Rev Epitope Map
Author Location	Rev
Epitope	`ISERILSTYL`	Epitope Alignment
Epitope Name	IY9(Rev)
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, QRQIRAISgRILSTYLGR, contains a variant, ISgRILSTY that differs by 1 substitution from the previously described HLA-A1 epitope ISERILSTY. None of the 4 HLA-A1 carriers responded to the variant ISgRILSTY.

References

Displaying record number 56454

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HXB2 Location	Rev(66-75) DNA(8498..8527)	Rev Epitope Map
Author Location	Rev
Epitope	`RSAEPVPLQL`	Epitope Alignment
		Show epitope variants
Epitope Name	RL10(Rev)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RSAEPVPLQ elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LGRsAEPVPLQLPPLERL. This epitope differs from the previously described HLA-B7-restricted epitope sequence, RPAEPVPLQ, at 1 residue, RsAEPVPLQL.
1 of the 9 HLA-B7 carriers responded to RsAEPVPLQL-containing peptide with a magnitude of CTL response of 750 SFC/million PBMC.

References

Displaying record number 55961

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HXB2 Location	Vpu(29-37) DNA(6146..6172)	Vpu Epitope Map
Author Location	Vpu
Epitope	`EYRKILRQR`	Epitope Alignment
Epitope Name	ER9(Vpu)
Subtype	B
Species (MHC/HLA)	human(A33)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A33-restricted epitope EYRKILRQR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide IVFIEYRKILRQRKIDRL.
3 of the 20 HLA-A33 carriers responded to EYRKILRQR-containing peptide with average magnitude of CTL response of 403 SFC/million PBMC.

References

Displaying record number 56044

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HXB2 Location	gp160(31-39) gp120(31-39) DNA(6315..6341)	gp160 Epitope Map
Author Location	gp120
Epitope	`AENLWVTVY`	Epitope Alignment
Epitope Name	AY9(gp120)
Subtype	B
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B44-restricted epitope AENLWVTVY elicited an immune response in Chinese HIV-1 positive subjects as part of peptides LGMLMICSAAENLWVTVY and AAENLWVTVYYGVPVWK.
1 of the 6 HLA-B44 carriers responded to AENLWVTVY-containing peptide, AAENLWVTVYYGVPVWK, with average magnitude of CTL response of 620 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56464

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HXB2 Location	gp160(37-46) gp120(37-46) DNA(6333..6362)	gp160 Epitope Map
Author Location	gp160
Epitope	`TVYYGVPVWK`	Epitope Alignment
Epitope Name	TK10(gp160)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3-restricted epitope TVYYGVPVWK elicited an immune response in Chinese HIV-1 positive subjects as part of peptides AAENLWVTVYYGVPVWK and TVYYGVPVWKEATTTLF.
2 of the 3 HLA-A3 carriers responded to a TVYYGVPVWK-containing peptide, TVYYGVPVWKEATTTLF, with average magnitude of CTL response of 200 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56018

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HXB2 Location	gp160(42-52) gp120(42-52) DNA(6348..6380)	gp160 Epitope Map
Author Location	gp120
Epitope	`VPVWKEATTTL`	Epitope Alignment
Epitope Name	VL11(gp120)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope VPVWKEATTTL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide TVYYGVPVWKEATTTLF.
3 of the 12 HLA-B35 carriers responded to a VPVWKEATTTL-containing peptide with average magnitude of CTL response of 167 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56431

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HXB2 Location	gp160(52-61) gp120(52-61) DNA(6378..6407)	gp160 Epitope Map
Author Location	gp120
Epitope	`LFCASDAKAY`	Epitope Alignment
Epitope Name	LY10(gp120)
Subtype	B
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence (VQKEATTTLFCASDAKAY) contains the exact sequence of a previously described HLA-A24 optimal epitope, LFCASDAKAY, none of the 30 HLA-A24 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56054

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	gp120
Epitope	`KAYDTEVHNVW`	Epitope Alignment
		Show epitope variants
Epitope Name	KW11(gp120)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope KAYDTEVHNVW elicited an immune response in Chinese HIV-1 positive subjects as a part of peptide KAYDTEVHNVW. The epitope differs from the previously described HLA-B58-restricted epitope sequence, KAYETEVHNVW, at 1 residue, KAYdTEVHNVW.
6 of the 14 HLA-B58 carriers responded to KAYdTEVHNVW-containing peptide with average magnitude of CTL response of 235 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56020

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HXB2 Location	gp160(78-86) gp120(78-86) DNA(6456..6482)	gp160 Epitope Map
Author Location	gp120
Epitope	`DPNPQEVVL`	Epitope Alignment
Epitope Name	DL9(gp120)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope DPNPQEVVL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide VPTDPNPQEVVLGNV.
4 of the 12 HLA-B35 carriers responded to a DPNPQEVVL-containing peptide with average magnitude of CTL response of 442 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56022

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HXB2 Location	gp160(104-112) gp120(104-112) DNA(6534..6560)	gp160 Epitope Map
Author Location	gp120
Epitope	`MHEDIISLW`	Epitope Alignment
Epitope Name	MW9(gp120)
Subtype	B
Species (MHC/HLA)	human(B38)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B38-restricted epitope MHEDIISLW elicited an immune response in Chinese HIV-1 positive subjects as part of peptides WKNNMVEQMHEDIISLW and QMHEDIISLWDQSLKPCV.

References

Displaying record number 55909

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HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	gp120
Epitope	`KLTPLCVTL`	Epitope Alignment
Epitope Name	KL9(gp120)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A2-restricted epitope KLTPLCVTL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide PCVKLTPLCVTLNCTDL.
3 of the 55 HLA-A2 carriers responded to KLTPLCVTL-containing peptide with average magnitude of CTL response of 110 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55927

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HXB2 Location	gp160(199-207) gp120(199-207) DNA(6819..6845)	gp160 Epitope Map
Author Location	gp160
Epitope	`SVITQACPK`	Epitope Alignment
Epitope Name	SK9(gp169)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope SVITQACPK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SVITQACPKVSFEPIPIH.
2 of the 28 HLA-A11 carriers responded to a SVITQACPK-containing peptide with average magnitude of CTL response of 150 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55942

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HXB2 Location	gp160(209-217) gp120(209-217) DNA(6849..6875)	gp160 Epitope Map
Author Location	gp120
Epitope	`SFEPIPIHY`	Epitope Alignment
Epitope Name	SY9(gp120)
Subtype	B
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A29-restricted epitope SFEPIPIHY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KVSFEPIPIHYCAPAGFA.
2 of the 8 HLA-A29 carriers responded to SFEPIPIHY-containing peptide with average magnitude of CTL response of 100 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56440

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HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	gp120
Epitope	`RPNNNTRKSI`	Epitope Alignment
Epitope Name	RI10(gp120)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence (NCTRPNNNTRKSITL) contains the exact sequence of a previously described HLA-B7 optimal epitope, RPNNNTRKSI, none of the 9 HLA-B7 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56455

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HXB2 Location	gp160(310-318) gp120(310-318) DNA(7152..7178)	gp160 Epitope Map
Author Location	gp120
Epitope	`HIGPGRAFY`	Epitope Alignment
Epitope Name	HY9(gp120)
Subtype	B
Species (MHC/HLA)	human(A*30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, ItlGPGRvwYTTGQII, contains a variant, tlGPGRvwY that differs by 4 substitutions from the previously described HLA-A30 epitope HIGPGRAFY. None of the 15 HLA-A30 carriers responded to the variant tlGPGRvwY.

References

Displaying record number 55910

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp120
Epitope	`LGPGRVWYTT`	Epitope Alignment
		Show epitope variants
Epitope Name	RI10(gp120)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope LGPGRVWYTT elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ITlGPGRvwyTtGQII. This epitope differs from the previously described HLA-A2-restricted epitope sequence, RGPGRAFVTI, at 5 residues, lGPGRvwyTt.
1 of the 55 HLA-A2 carriers responded to an lGPGRvwyTt-containing peptide with a magnitude of CTL response of 55 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56006

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HXB2 Location	gp160(375-383) gp120(375-383) DNA(7347..7373)	gp160 Epitope Map
Author Location	gp120
Epitope	`SFNCGGEFF`	Epitope Alignment
Epitope Name	SF9(gp120)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope SFNCGGEFF elicited an immune response in Chinese HIV-1 positive subjects as peptide GDPEIVMHSFNCGGEFFY but not as peptide SFNCGGEFFYCNTTQLF.
2 of the 21 HLA-B15 carriers responded to FLGKIWPShK-containing peptide with average magnitude of CTL response of 495 SFC/million PBMC.

References

Displaying record number 55943

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HXB2 Location	gp160(375-384) gp120(375-384) DNA(7347..7376)	gp160 Epitope Map
Author Location	gp120
Epitope	`SFNCGGEFFY`	Epitope Alignment
Epitope Name	SY10(gp120)
Subtype	B
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A29-restricted epitope SFNCGGEFFY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide GDPEIVMHSFNCGGEFFY.

References

Displaying record number 55932

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HXB2 Location	gp160(383-391) gp120(383-391) DNA(7371..7397)	gp160 Epitope Map
Author Location	gp120
Epitope	`FYCNTTQLF`	Epitope Alignment
Epitope Name	FF9(gp120)
Subtype	B
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A24-restricted epitope FYCNTTQLF elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SFNCGGEFFYCNTTQLF.
2 of the 30 HLA-A24 carriers responded to FYCNTTQLF-containing peptide with average magnitude of CTL response of 120 SFC/million PBMC.

References

Displaying record number 56445

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HXB2 Location	gp160(416-424) gp120(416-424) DNA(7470..7496)	gp160 Epitope Map
Author Location	gp120
Epitope	`LPCRIKWII`	Epitope Alignment
Epitope Name	LI9(gp120)
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequence (LVEICTEMEKEGKISKI) contains the exact sequence of a previously described HLA-B51 optimal epitope, EKEGKISKI, none of the 15 HLA-B51 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55957

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HXB2 Location	gp160(419-427) gp120(419-427) DNA(7479..7505)	gp160 Epitope Map
Author Location	gp120
Epitope	`RIKQFINMW`	Epitope Alignment
Epitope Name	RW9(gp120)
Subtype	B
Species (MHC/HLA)	human(A32)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A32-restricted epitope RIKQFINMW elicited an immune response in Chinese HIV-1 positive subjects.

References

Displaying record number 55956

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HXB2 Location	gp160(419-427) gp120(419-427) DNA(7479..7505)	gp160 Epitope Map
Author Location	gp120
Epitope	`RIKQIINMW`	Epitope Alignment
Epitope Name	RW9(gp120)
Subtype	B
Species (MHC/HLA)	human(A32)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Prewviously described HLA-A32-restricted epitope RIKQIINMW elicited an immune response in Chinese HIV-1 positive subjects as part of peptides ENITLPCRIKQIINMW and CRIKQIINMWQEVGKAMY.

References

Displaying record number 56446

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	gp41
Epitope	`RAIEAQQHL`	Epitope Alignment
Epitope Name	RL9(gp41)
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide sequences (IVQQQSNLLRAIEAQQHL and LRAIEAQQHLLQLTVWGI) contain the exact sequence of a previously described HLA-B51 epitope, RAIEAQQHL, none of the 15 HLA-B51 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55958

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HXB2 Location	gp160(584-592) gp41(73-81) DNA(7974..8000)	gp160 Epitope Map
Author Location	gp41
Epitope	`ERYLKDQQL`	Epitope Alignment
Epitope Name	EL9(gp41)
Subtype	B
Species (MHC/HLA)	human(A32)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A32-restricted epitope ERYLKDQQL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide RVLAVERYLKDQQLLGIW.

References

Displaying record number 55933

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HXB2 Location	gp160(585-593) gp41(74-82) DNA(7977..8003)	gp160 Epitope Map
Author Location	gp41
Epitope	`RYLKDQQLL`	Epitope Alignment
Epitope Name	RL9(gp41)
Subtype	B
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A24-restricted epitope RYLKDQQLL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide RVLAVERYLKDQQLLGIW.
7 of the 30 HLA-A24 carriers responded to RYLKDQQLL-containing peptide with average magnitude of CTL response of 551 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55934

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HXB2 Location	gp160(586-593) gp41(75-82) DNA(7980..8003)	gp160 Epitope Map
Author Location	gp41
Epitope	`YLKDQQLL`	Epitope Alignment
Epitope Name	RL9(gp41)
Subtype	B
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A24-restricted epitope YLKDQQLL elicited an immune response in Chinese HIV-1 positive subjects RVLAVERYLKDQQLLGIW.
7 of the 30 HLA-A24 carriers responded to YLKDQQLL-containing peptide with average magnitude of CTL response of 551 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56021

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HXB2 Location	gp160(606-614) gp41(95-103) DNA(8040..8066)	gp160 Epitope Map
Author Location	gp41
Epitope	`TAVPWNASW`	Epitope Alignment
Epitope Name	TW9(gp41)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope TAVPWNASW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KLICTTAVPWNASWSNK.
1 of the 12 HLA-B35 carriers responded to a TAVPWNASW-containing peptide with average magnitude of CTL response of 800 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56436

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HXB2 Location	gp160(698-707) gp41(187-196) DNA(8316..8345)	gp160 Epitope Map
Author Location	gp41
Epitope	`VFAVLSIVNR`	Epitope Alignment
Epitope Name	VR10(gp41)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B7-restricted epitope VFAVLSIVNR elicited no immune response in Chinese HIV-1 positive subjects as part of peptide LVGLRIVFAVLSIVNRVR.
Although the tested peptide sequence (LVGLRIVFAVLSIVNRVR) contains the exact sequence of a previously described HLA-B7 optimal epitope, VFAVLSIVNR, none of the 9 HLA-B7 carriers responded to it (author communication and Fig.1).

References

Displaying record number 56434

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HXB2 Location	gp160(704-712) gp41(193-201) DNA(8334..8360)	gp160 Epitope Map
Author Location	gp41
Epitope	`IVNRNRQGY`	Epitope Alignment
Epitope Name	IY9(gp41)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide AVLSIVNRNRQGYSPLSF contains the exact sequence of a previously described HLA-A30 epitope, IVNRNRQGY, none of the 9 HLA-A30 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55953

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HXB2 Location	gp160(767-780) gp41(256-269) DNA(8523..8564)	gp160 Epitope Map
Author Location	gp41
Epitope	`SYHRLRDLLLIVTR`	Epitope Alignment
Epitope Name	SR14(gp41)
Subtype	B
Species (MHC/HLA)	human(A3, A31)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A3- and -A31-restricted epitope SYHRLRDLLLIVTR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SLCLFSYHRLRDLLLIV.

References

Displaying record number 56428

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HXB2 Location	gp160(770-780) gp41(259-269) DNA(8532..8564)	gp160 Epitope Map
Author Location	gp160
Epitope	`RLRDLLLIVTR`	Epitope Alignment
Epitope Name	RR11(gp160)
Subtype	B
Species (MHC/HLA)	human(A3, A31)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
HLA-A*03-restricted epitope RLRDLLLIVTR elicited no immune response in Chinese HIV-1 positive subjects as part of peptide HRLRDLLLIVTRIVELL.
Although the tested peptide sequence HRLRDLLLIVTRIVELL contains the exact sequence of a previously described HLA-A3 epitope, RLRDLLLIVTR, none of the 3 HLA-A3 carriers responded to it (author communication and Fig.1). When tested in Chinese HLA-A31 positive subjects, this peptide did elicit an immune response.

References

Displaying record number 55971

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HXB2 Location	gp160(777-785) gp41(266-274) DNA(8553..8579)	gp160 Epitope Map
Author Location	gp41
Epitope	`IVTRIVELL`	Epitope Alignment
Epitope Name	IL9(gp41)
Subtype	B
Species (MHC/HLA)	human(A68)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A68-restricted epitope IVTRIVELL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LIVTRIVELLGRRGWEAL.

References

Displaying record number 56460

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HXB2 Location	gp160(787-795) gp41(276-284) DNA(8583..8609)	gp160 Epitope Map
Author Location	gp41
Epitope	`RRGWEVLKY`	Epitope Alignment
Epitope Name	RY9(gp41)
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, LLGRRGWEaLKYLWNLL, contains a variant, RRGWEaLKY that differs by 1 substitution from the previously described HLA-A1 optimal epitope RRGWEVLKY. None of the 4 HLA-A1 carriers responded to the variant RRGWEaLKY.

References

Displaying record number 55951

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HXB2 Location	gp160(794-802) gp41(283-291) DNA(8604..8630)	gp160 Epitope Map
Author Location	gp41
Epitope	`KYLWNLLQY`	Epitope Alignment
		Show epitope variants
Epitope Name	KY9(gp41)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope KYLWNLLQY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EALKYLWNLLQYWIQELK. This epitope differs from the previously described HLA-A30-restricted epitope sequence, KYCWNLLQY, at 1 residue, KYlWNLLQY.
3 of the 15 HLA-A30 carriers responded to an KYlWNLLQY-containing peptide with average magnitude of CTL response of 110 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56039

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HXB2 Location	gp160(805-814) gp41(294-303) DNA(8637..8666)	gp160 Epitope Map
Author Location	gp41
Epitope	`QELKNSAVSL`	Epitope Alignment
Epitope Name	QL10(gp41)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B40-restricted epitope QELKNSAVSL elicited an immune response in Chinese HIV-1 positive subjects LLQYWIQELKNSAVSLL.
1 of the 20 HLA-B40 carriers responded to QELKNSAVSL-containing peptide with average magnitude of CTL response of 190 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55911

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HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41
Epitope	`SLLNATAIAV`	Epitope Alignment
		Show epitope variants
Epitope Name	SV10(gp41)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope SLLNATAIAV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide ELKNSAVSLLNATAIAVA. This epitope differs from the previously described HLA-A2-restricted epitope sequence, SLLNATDIAV, at 1 residue, SLLNATaIAV.
2 of the 55 HLA-A2 carriers responded to SLLNATAIaV-containing peptide with average magnitude of CTL response of 270 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55962

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HXB2 Location	gp160(831-838) gp41(320-327) DNA(8715..8738)	gp160 Epitope Map
Author Location	gp41
Epitope	`EVVQRAYR`	Epitope Alignment
		Show epitope variants
Epitope Name	ER8(gp41)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope EVVQRAYR elicited an immune response in Chinese HIV-1 positive subjects as part of peptides AVAEGTDRVIEVVQRAYR and VIEVVQRAYRAILHIPTR. This epitope differs from the previously described HLA-A33-restricted epitope, EVAQRAYR, at 1 residue, EVvQRAYR.
2 of the 20 HLA-A33 carriers responded to an EVvQRAYR-containing peptide with average magnitude of CTL response of 55 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55982

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	gp41
Epitope	`IPTRIRQGL`	Epitope Alignment
		Show epitope variants
Epitope Name	IL9(gp41)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope IPTRIRQGL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide YRAILHIPTRIRQGLERA. This epitope differs from the previously described HLA-B7-restricted epitope sequence, IPRRIRQGL, at 1 residue, IPtRIRQGL.
1 of the 9 HLA-B7 carriers responded to IPtRIRQGL-containing peptide with average magnitude of CTL response of 70 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56421

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HXB2 Location	gp160(846-854) gp41(335-343) DNA(8760..8786)	gp160 Epitope Map
Author Location	gp41
Epitope	`RIRQGLERA`	Epitope Alignment
Epitope Name	RA10(gp41)
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide TRIRQGLERALL contains the exact sequence of a previously described HLA-A2 optimal epitope, RIRQGLERA, none of the 55 HLA-A2 carriers responded to it.

References

Displaying record number 55996

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HXB2 Location	Nef(19-27) DNA(8851..8877)	Nef Epitope Map
Author Location	Nef
Epitope	`RMRRAEPAA`	Epitope Alignment
Epitope Name	RA9(Nef)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope RMRRAEPAA elicited an immune response in Chinese HIV-1 positive subjects as part of peptide PSVRERMRRAEPAADGV.
2 of the 21 HLA-B15 carriers responded to RMRRAEPAA-containing peptide with average magnitude of CTL response of 115 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56443

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HXB2 Location	Nef(37-45) DNA(8905..8931)	Nef Epitope Map
Author Location	Nef
Epitope	`LEKHGAITS`	Epitope Alignment
Epitope Name	LS9(Nef)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Although the tested peptide SRDLEKHGAITSSNTAA contains the exact sequence of a previously described HLA-B40 optimal epitope, LEKHGAITS, none of the 20 HLA-B40 carriers responded to it (author communication and Fig.1).

References

Displaying record number 55974

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HXB2 Location	Nef(68-76) DNA(8998..9024)	Nef Epitope Map
Author Location	Nef
Epitope	`FPVRPQVPL`	Epitope Alignment
		Show epitope variants
Epitope Name	FL9(Nef)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope FPVRPQVPL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EVGFPVRPQVPLRPMTYK. This epitope differs from the previously described HLA-B7-restricted epitope, FPVTPQVPL, at 1 residue, FPVrPQVPL.
7 of the 9 HLA-B7 carriers responded to FPVrPQVPL-containing peptide with average magnitude of CTL response of 370 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55973

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HXB2 Location	Nef(68-77) DNA(8998..9027)	Nef Epitope Map
Author Location	Nef
Epitope	`FPVRPQVPLR`	Epitope Alignment
		Show epitope variants
Epitope Name	FR10(Nef)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope FPVRPQVPL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EVGFPVRPQVPLRPMTYK. This epitope differs from the previously described HLA-B7-restricted epitope, FPVTPQVPLR, at 1 residue, FPVrPQVPLR.
7 of the 9 HLA-B7 carriers responded to FPVrPQVPLR-containing peptide with average magnitude of CTL response of 370 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55975

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HXB2 Location	Nef(71-79) DNA(9007..9033)	Nef Epitope Map
Author Location	Nef
Epitope	`RPQVPLRPM`	Epitope Alignment
		Show epitope variants
Epitope Name	TM9(Nef)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RPQVPLRPM elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EVGFPVRPWVPLRPMTYK. This epitope differs from the previously described HLA-B7 epitope, TPQVPLRPM, at 1 residue, rPQVPLRPM.
7 of the 9 HLA-B7 carriers responded to rPQVPLRPM-containing peptide with average magnitude of CTL response of >370 SFC/million PBMC.

References

Displaying record number 55914

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef
Epitope	`QVPLRPMTYK`	Epitope Alignment
Epitope Name	QK10(Nef)
Subtype	B
Species (MHC/HLA)	human(A11, A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
HLA-A3- and -A11-restricted epitope QVPLRPMTYK elicited an immune response in Chinese HIV-1 positive subjects as part of peptides EVGFPVRPQVPLRPMTYK and QVPLRPMTYKGALDLSHF.
1 of the 3 HLA-A3 carriers responded to a QVPLRPMTYK-containing peptide with average magnitude of CTL response of 230 SFC/million PBMC (author communication and Fig.1). 13 of the 28 HLA-A11 carriers responded to QVPLRPMTYK-containing peptide EVGFPVRPQVPLRPMTYK with average magnitude of CTL response of 263 SFC/million PBMC; and 5 of the 28 HLA-A11 carriers responded to QVPLRPMTYK-containing peptide QVPLRPMTYKGALDLSHF with average magnitude of CTL response of 133 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56013

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HXB2 Location	Nef(74-81) DNA(9016..9039)	Nef Epitope Map
Author Location	Nef
Epitope	`VPLRPMTY`	Epitope Alignment
Epitope Name	VY8(Nef)
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B35-restricted epitope VPLRPMTY elicited an immune response in Chinese HIV-1 positive subjects as part of peptides EVGFPVRPQVPLRPMTYK and QVPLRPMTYKGALDLSHF.
9 of the 12 HLA-B35 carriers responded to VPLRPMTY-containing peptide EVGFPVRPQVPLRPMTYK with average magnitude of CTL response of >654 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55921

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HXB2 Location	Nef(75-82) DNA(9019..9042)	Nef Epitope Map
Author Location	Nef
Epitope	`PLRPMTYK`	Epitope Alignment
Epitope Name	PK8(Nef)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope PLRPMTYK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QVPLRPMTYKGALDLSHF.
5 of the 28 HLA-A11 carriers responded to a PLRPMTYK-containing peptide QVPLRPMTYKGALDLSHF with average magnitude of CTL response of 133 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55977

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HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef
Epitope	`RPMTYKAAV`	Epitope Alignment
Epitope Name	RL9(Nef)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B7-restricted epitope RPMTYKAAV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QVPLRPMTYKGALDLSHF.

References

Displaying record number 55976

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HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef
Epitope	`RPMTYKGAL`	Epitope Alignment
		Show epitope variants
Epitope Name	RL9(Nef)
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined HLA-B7-restricted epitope RPMTYKGAL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QVPLRPMTYKGALDLSHF. This epitope differs from the previously described HLA-B7-restricted epitopes RPMTYKAAL and RPMTYKAAV, at 1 or 2 residues, RPMTYKgAL and RPMTYKgAl.

References

Displaying record number 55901

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HXB2 Location	Nef(83-91) DNA(9043..9069)	Nef Epitope Map
Author Location	Nef
Epitope	`GALDLSFFL`	Epitope Alignment
		Show epitope variants
Epitope Name	GL9(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope GALDLSFFL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide YKGALDLSHFLKEKGGL. This epitope differs from the previously described HLA-A2-restricted epitope, GAFDLSFFL, at 1 residue, GAlDLSFFL.
21 of the 55 HLA-A2 carriers responded to GAlDLSFFL-containing peptide with average magnitude of CTL response of 226 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55922

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HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location	Nef
Epitope	`AVDLSHFLK`	Epitope Alignment
Epitope Name	AK9(Nef)
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A11-restricted epitope AVDLSHFLK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide YKGALDLSHFLKEKGGL.
11 of the 28 HLA-A11 carriers responded to FLGKIWPShK-containing peptide with average magnitude of CTL response of 196 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55915

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HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location	Nef
Epitope	`ALDLSHFLK`	Epitope Alignment
		Show epitope variants
Epitope Name	AK10(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope ALDLSHFLK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide YKGALGLSHFLKEKGGL. This epitope differs from the previously published HLA-A3- and -A11-restricted epitope AVDLSHFLK, at 1 residue, AlDLSHFLK.
1 of the 3 HLA-A3 carriers responded to AlDLSHFLK-containing peptide with average magnitude of CTL response of 80 SFC/million PBMC and 11 of the 28 HLA-A11 carriers responded with an average magnitude of CTL response of 196 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56035

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HXB2 Location	Nef(92-100) DNA(9070..9096)	Nef Epitope Map
Author Location	Nef
Epitope	`KEKGGLEGL`	Epitope Alignment
Epitope Name	KL9(Nef)
Subtype	B
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
HLA-B40-restricted epitope KEKGGLEGL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SHFLKEKGGLEGLIYSQK.
11 of the 20 HLA-B40 carriers responded to KEKGGLEGL-containing peptide with average magnitude of CTL response of 321 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55988

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HXB2 Location	Nef(106-114) DNA(9112..9138)	Nef Epitope Map
Author Location	Nef
Epitope	`RQDILDLWV`	Epitope Alignment
		Show epitope variants
Epitope Name	RV9(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RQDILDLWV elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QKRQDILDLWVYHTQGYF. This epitope differs from the previously described HLA-B13-restricted epitope RQDILDLWi at 1 residue, RQDILDLWv.
3 of the 29 HLA-B13 carriers responded to RQDILDLWv-containing peptide with average magnitude of CTL response of 50 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55978

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HXB2 Location	Nef(106-115) DNA(9112..9141)	Nef Epitope Map
Author Location	Nef
Epitope	`RQDILDLWVY`	Epitope Alignment
		Show epitope variants
Epitope Name	RY10(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RQDILDLWVY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QKRQDILDLWVYHTQGYF. This epitope differs from the previously described HLA-B7-restricted epitope RQDILDLWIY, at 1 residue, RQDILDLWvY.
2 of the 9 HLA-B7 carriers responded to a RQDILDLWvY-containing peptide with average magnitude of CTL response of 45 SFC/million PBMC.

References

Displaying record number 55997

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HXB2 Location	Nef(117-127) DNA(9145..9177)	Nef Epitope Map
Author Location	Nef
Epitope	`TQGYFPDWQNY`	Epitope Alignment
Epitope Name	TY11(Nef)
Subtype	B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-B15-restricted epitope TQGYFPDWQNY elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LWVYHTQGYFPDWQNY.
9 of the 21 HLA-B15 carriers responded to TQGYFPDWQNY-containing peptide with average magnitude of CTL response of 327 SFC/million PBMC.

References

Displaying record number 56463

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HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location	Nef
Epitope	`YFPDWQNYT`	Epitope Alignment
Epitope Name	YT9(Nef)
Subtype	B
Species (MHC/HLA)	human(A1, A29)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A29-restricted eiptope YFPDWQNYT elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QGYFPDWQNYTGPGRF.
Although the tested peptide sequence, QGYFPDWQNYTGPGRF, contains the exact sequence of a previously described HLA-A1 optimal epitope, YFPDWQNYT, none of the 4 HLA-A1 carriers responded to it. 1 of the 8 HLA-A29 carriers responded to YFPDWQNYT-containing peptide with a magnitude of CTL response of 90 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55941

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HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location	Nef
Epitope	`YFPDWQNYT`	Epitope Alignment
Epitope Name	YT9(Nef)
Subtype	B
Species (MHC/HLA)	human(A*29)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	optimal epitope, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
HLA-A*29-restricted epitope YFPDWQNYT elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QGYFPDWQNYTPGPGRF.
>10% of the 4 HLA-A*29 carriers responded to YFPDWQNYT-containing peptide with average magnitude of CTL response of ˜100 SFC/million PBMC.

References

Displaying record number 55979

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HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef
Epitope	`TPGPGRFPL`	Epitope Alignment
		Show epitope variants
Epitope Name	TL10(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope TPGPGRFPL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QNYTPGPGRFPLTFGWCF. This epitope differs from the previously described HLA-B7 epitope TPGPGVRYPL, at 3 residues, TPGPGrf-PL.
1 of the 9 HLA-B7 carriers responded to TPGPGrf-PL-containing peptide with average magnitude of CTL response of 120 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55960

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef
Epitope	`GRFPLTFGW`	Epitope Alignment
		Show epitope variants
Epitope Name	TW9(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope GRFPLTFGW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QNYTPGPGRFPLTFGWCF. This epitope differs from the previously described HLA-A33-restricted epitope, TRYPLTFGW, at 2 residues, gRfPLTFGW.
5 of the 20 HLA-A33 carriers responded to gRfPLTFGW-containing peptide with average magnitude of CTL response of 343 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55930

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HXB2 Location	Nef(134-141) DNA(9196..9219)	Nef Epitope Map
Author Location	Nef
Epitope	`RFPLTFGW`	Epitope Alignment
		Show epitope variants
Epitope Name	RW8(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RFPLTFGW elicited an immune response in Chinese HIV-1 positive subjects as part of peptide QNYTPGPGRFPLTFGWCF. This epitope differs from the previously described HLA-A24 epitope, RYPLTFGW, at 1 residue, RfPLTFGW.
16 of the 30 HLA-A24 carriers responded to RfPLTFGW-containing peptide with average magnitude of CTL response of 558 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 55902

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HXB2 Location	Nef(136-145) DNA(9202..9231)	Nef Epitope Map
Author Location	Nef
Epitope	`PLTFGWCFKL`	Epitope Alignment
		Show epitope variants
Epitope Name	PL11(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope PLTFGWCFKL elicited an immune response in Chinese HIV-1 positive subjects as part of peptides QNYTPGPGRFPLTFGWCF and RFPLTFGWCFKLVPV. This epitope differs from the previously published HLA-A2-restricted epitope PLTFGWCYKL, at 1 residue, PLTFGWCfKL.
10 of the 55 HLA-A2 carriers responded to PLTFGWCfKL-containing peptide with average magnitude of CTL response of 192 SFC/million PBMC.

References

Displaying record number 55903

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef
Epitope	`VLMWKFDSRL`	Epitope Alignment
		Show epitope variants
Epitope Name	VL10(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope VLMWKFDSRL elicited an immune response in Chinese HIV-1 positive subjects as part of peptide PEKEVLMWKFDSRLAFHH. This epitope differs from the previously described HLA-A2-restricted epitope VLEWRFDSRL, at 2 residues, VLmWkFDSRL.
5 of the 55 HLA-A2 carriers responded to a VLmWkFDSRL-containing peptide with average magnitude of CTL response of 400 SFC/million PBMC.

References

Displaying record number 55998

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HXB2 Location	Nef(183-191) DNA(9343..9369)	Nef Epitope Map
Author Location	Nef
Epitope	`WKFDSRLAF`	Epitope Alignment
		Show epitope variants
Epitope Name	WF9(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope WKFDSRLAF elicited an immune response in Chinese HIV-1 positive subjects as part of peptide PEKEVLMWKFDSRLAFHH. This epitope differs from teh previously described HLA-B15-restricted epitope, WRFDSRLAF, at 1 residue, WkFDSRLAF.
2 of the 21 HLA-B15 carriers responded to WkFDSRLAF-containing peptide with average magnitude of CTL response of 165 SFC/million PBMC (author communication and Fig.1).

References

Displaying record number 56462

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HXB2 Location	Nef(183-192) DNA(9343..9372)	Nef Epitope Map
Author Location	Nef
Epitope	`WRFDSRLAFH`	Epitope Alignment
Epitope Name	WH10(Nef)
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, PEKEVLMWRFDSRLAFHH, contains a variant, WkFDSRLAFH that differs by 1 substitution from the previously described HLA-A1-restricted epitope WRFDSRLAFH. None of the 4 HLA-A1 carriers responded to variant WkFDSRLAFH (author communication and Fig.1).

References

Displaying record number 56049

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HXB2 Location	Nef(188-196) DNA(9358..9384)	Nef Epitope Map
Author Location	Nef
Epitope	`RLAFHHMAR`	Epitope Alignment
		Show epitope variants
Epitope Name	RR9(Nef)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Author defined epitope RLAFHHMAR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide KFDSRLAFHHMAREKH. This epitope differs from the previously described HLA-B52-restricted epitope, RLAFHHVAR, at 1 residue, RLAFHHmAR.
1 of the 5 HLA-B52 carriers responded to RLAFHHmAR-containing peptide with average magnitude of CTL response of 40 SFC/million PBMC.

References

Displaying record number 56448

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HXB2 Location	Nef(190-198) DNA(9364..9390)	Nef Epitope Map
Author Location	Nef
Epitope	`AFHHVAREL`	Epitope Alignment
Epitope Name	AL9(Nef)
Subtype	B
Species (MHC/HLA)	human(B52)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	non-susceptible form, chronic infection

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
The tested peptide sequence, AFHHmAREkHPEYYKDC, contains a variant, AFHHmAREk that differs by 2 substitutions from the previously described HLA-B52 epitope AFHHVAREL. None of the 4 HLA-B52 carriers responded to variant AFHHMAREK.