Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 746

Download this epitope record as JSON.

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	Env
Epitope	`RGPGRAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords	Th1

Vaccine Details

Vaccine type	DNA
Vaccine strain	B clade IIIB
Vaccine component	gp160, Rev
Adjuvant	IL-12, IL-15, IL-2

Notes

A study of the DNA vaccine pCMV160IIIB/REV with IL-15 and IL-2 or IL-12 expression plasmids.
Intranasal immunization of BALB/c mice with HIV DNA and IL-15 plasmid induced increased Th1 and CTL responses.
Co-administration of IL-15 with IL-12 or IL-2 plasmids did not alter the effect of IL-15.
Both the CTL (peptide pulsed targets) and DTH response (injection of peptide into footpad) to this peptide was monitored.
The Ab response to NNTRKSIRIQRGPGRAFVTIGKIGN was monitored, and IL-15 co-administration resulted in a decrease in the IgG1/IgG2a ratio.

References

Xin1999 K. Q. Xin, K. Hamajima, S. Sasaki, T. Tsuji, S. Watabe, E. Okada, and K. Okuda. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine. Vaccine, 17:858-66, 1999. PubMed ID: 10067692. Show all entries for this paper.