Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 57478

HXB2 Location	Gag(36-44) p17(36-44) DNA(895..921)	Gag Epitope Map
Author Location	Gag(36-44)
Epitope	WASRELERF	Epitope Alignment
Epitope Name	WF9
Subtype	B
Species (MHC/HLA)	human(B*3501)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	computational epitope prediction

Notes

• 44 candidate B*3501-restricted epitopes were predicted by computational analysis of HIV-1 Gag. Twelve candidates had significant binding affinity for HLA-B*3501. Two previously-unknown candidates also had positive EliSpot responses among 4 chronically-infected B35-positive patients carrying subtype B HIV-1.
• Previously-documented B35-restricted epitope WASRELERF had significant binding affinity for HLA-B*3501 and a positive IFN-gamma EliSpot response in 2/4 HLA-B*3501-positive patients.

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.

Displaying record number 57480

HXB2 Location	Gag(124-132) p17(124-132) DNA(1159..1185)	Gag Epitope Map
Author Location	Gag(124-132)
Epitope	NSSKVSQNY	Epitope Alignment
Epitope Name	NY9
Subtype	B
Species (MHC/HLA)	human(B*3501)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	computational epitope prediction

Notes

• 44 candidate B*3501-restricted epitopes were predicted by computational analysis of HIV-1 Gag. Twelve candidates had significant binding affinity for HLA-B*3501. Two previously-unknown candidates also had positive EliSpot responses among 4 chronically-infected B35-positive patients carrying subtype B HIV-1.
• Previously-documented B35-restricted epitope NSSKVSQNY had a positive IFN-gamma EliSpot response in 1/4 HLA-B*3501-positive patients.

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.

Displaying record number 57477

HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	Gag(216-224)
Epitope	HPVHAGPIA	Epitope Alignment
Epitope Name	HA9
Subtype	B
Species (MHC/HLA)	human(B*3501)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	computational epitope prediction

Notes

• 44 candidate B*3501-restricted epitopes were predicted by computational analysis of HIV-1 Gag. Twelve candidates had significant binding affinity for HLA-B*3501. Two previously-unknown candidates also had positive EliSpot responses among 4 chronically-infected B35-positive patients carrying subtype B HIV-1.
• Novel epitope HPVHAGPIA had significant binding affinity for HLA-B*3501 and a positive IFN-gamma EliSpot response in 4/4 HLA-B*3501-positive patients.

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.

Displaying record number 57479

HXB2 Location	Gag(254-262) p24(122-130) DNA(1549..1575)	Gag Epitope Map
Author Location	Gag(254-262)
Epitope	PPIPVGEIY	Epitope Alignment
Epitope Name	PY9
Subtype	B
Species (MHC/HLA)	human(B*3501)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	computational epitope prediction

Notes

• 44 candidate B*3501-restricted epitopes were predicted by computational analysis of HIV-1 Gag. Twelve candidates had significant binding affinity for HLA-B*3501. Two previously-unknown candidates also had positive EliSpot responses among 4 chronically-infected B35-positive patients carrying subtype B HIV-1.
• Previously-documented B35-restricted epitope PPIPVGEIY had significant binding affinity for HLA-B*3501 and a positive IFN-gamma EliSpot response in 2/4 HLA-B*3501-positive patients.

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.

Displaying record number 57476

HXB2 Location	Gag(484-492) p2p7p1p6(121-129) DNA(2239..2265)	Gag Epitope Map
Author Location	Gag(484-492)
Epitope	YPLTSLRSL	Epitope Alignment
Epitope Name	YL9
Subtype	B
Species (MHC/HLA)	human(B*3501)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	computational epitope prediction

Notes

• 44 candidate B*3501-restricted epitopes were predicted by computational analysis of HIV-1 Gag. Twelve candidates had significant binding affinity for HLA-B*3501. Two previously-unknown candidates also had positive EliSpot responses among 4 chronically-infected B35-positive patients carrying subtype B HIV-1.
• Novel epitope YPLTSLRSL had significant binding affinity for HLA-B*3501 and a positive IFN-gamma EliSpot response in 1/4 HLA-B*3501-positive patients.

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.