Search CTL/CD8+ T-Cell Epitope Database

Found 28 matching records:

Displaying record number 61528

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HXB2 Location	Gag(31-41) p17(31-41) DNA(880..912)	Gag Epitope Map
Author Location	p17(31-41)
Epitope	`LKHIVWASREL`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag LL11
Subtype	B
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade B epitope Gag LL11, LKHIVWASREL, was found in 1182/1644 Clade B and 18/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 2/26 A/E-infected subjects of the KI cohort.
CTL from A/E-infected subjects stimulated by the consensus B LL11 peptide used did not cross-recognize the clade A/E derived peptide, LL1-1M-4L.

References

Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.

Displaying record number 61529

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HXB2 Location	Gag(31-41) p17(31-41) DNA(880..912)	Gag Epitope Map
Author Location	p17(31-41)
Epitope	`MKHLVWASREL`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag LL11-1M-4L
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-388: A02:06, B40:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade A/E epitope Gag LL11-1M-4L, LKHIVWASREL, was found in no Clade B and 147/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 14/26 A/E-infected subjects of the KI cohort.
CTL from A/E-infected subjects stimulated by the consensus B LL11 peptide used did not cross-recognize the clade A/E derived peptide, LL1-1M-4L.

References

Displaying record number 61531

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HXB2 Location	Gag(39-46) p17(39-46) DNA(904..927)	Gag Epitope Map
Author Location	p17(39-46)
Epitope	`RELERFAL`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag RV8-8L
Subtype	CRF01_AE
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-388: A02:06, B40:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade A/E epitope Gag RV8-8L, RELERFAL, was found in 111/1644 Clade B and 217/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 17/26 A/E-infected subjects of the KI cohort. CTL from A/E-infected subjects stimulated by the consensus B RV8 peptide used cross-recognized both clades B and A/E derived peptides, RV8 and RV8-8L, RELERFAl.
CTL from A/E-infected subjects stimulated by the consensus B RV8 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61530

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HXB2 Location	Gag(39-46) p17(39-46) DNA(904..927)	Gag Epitope Map
Author Location	p17(39-46)
Epitope	`RELERFAV`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag RV8
Subtype	B
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade B epitope Gag RV8, RELERFAV, was found in 1299/1644 Clade B and 20/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 4/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B and A/E peptides evenly.
CTL from A/E-infected subjects stimulated by the consensus B RV8 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61532

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HXB2 Location	Gag(210-217) p24(78-85) DNA(1417..1440)	Gag Epitope Map
Author Location	p24(78-85)
Epitope	`AEWDRLHP`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag AP8
Subtype	B
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade B epitope Gag p24 AP8, AEWDRLHP, was found in 1263/1644 Clade B and 53/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 1/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B and A/E peptides evenly.
CTL from A/E-infected subjects stimulated by the consensus B RV8 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61533

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HXB2 Location	Gag(210-217) p24(78-85) DNA(1417..1440)	Gag Epitope Map
Author Location	p24(78-85)
Epitope	`AEWDRVHP`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag p24 AP8-6V
Subtype	CRF01_AE
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-388: A02:06, B40:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade A/E epitope Gag p24 AP8-6V, AEWDRVHP, was found in 128/1644 Clade B and 185/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 10/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clade B AP8 and clade A/E AP8 equally.
CTL from A/E-infected subjects stimulated by the consensus B AP8 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61534

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HXB2 Location	Gag(210-218) p24(78-86) DNA(1417..1443)	Gag Epitope Map
Author Location	p24(78-86)
Epitope	`AEWDRLHPV`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag AV9
Subtype	B
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade B epitope Gag p24 AV9, AEWDRLHPV, was found in 1135/1644 Clade B and 47/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 1/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B and A/E peptides evenly.
CTL from A/E-infected subjects stimulated by the consensus B AV9 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61535

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HXB2 Location	Gag(210-218) p24(78-86) DNA(1417..1443)	Gag Epitope Map
Author Location	p24(78-86)
Epitope	`AEWDRVHPV`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag p24 AV9-6V
Subtype	CRF01_AE
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-388: A02:06, B40:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade A/E epitope Gag p24 AV9-6V, AEWDRVHPV, was found in 121/1644 Clade B and 178/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 8/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B and A/E peptides evenly.
CTL from A/E-infected subjects stimulated by the consensus B AV9 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61537

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HXB2 Location	Gag(211-221) p24(79-89) DNA(1420..1452)	Gag Epitope Map
Author Location	p24(79-89)
Epitope	`EWDRVHPVHAG`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag p24 EG11-5V
Subtype	CRF01_AE
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade A/E epitope Gag p24 EG11-5V, EWDRVHPVHAG, was found in 107/1644 Clade B and 149/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 5/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clade B EG11 more strongly than clade A/E peptide EG11.
CTL from A/E-infected subjects stimulated by the consensus B EG11 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61536

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HXB2 Location	Gag(211-221) p24(79-89) DNA(1420..1452)	Gag Epitope Map
Author Location	p24(79-89)
Epitope	`EWDRLHPVHAG`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag p24 EG11
Subtype	B
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade B epitope Gag p24 EG11, EWDRLHPVHAG, was found in 921/1644 Clade B and 48/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 1/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clade B EG11 peptide more strongly than clade A/E EG11 peptide.
CTL from A/E-infected subjects stimulated by the consensus B EG11 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61538

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HXB2 Location	Gag(275-282) p24(143-150) DNA(1612..1635)	Gag Epitope Map
Author Location	p24(143-150)
Epitope	`RMYSPTSI`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag RI8
Subtype	B
Species (MHC/HLA)	human(B*52:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade B epitope Gag p24 RI8, RMYSPTSI, was found in 1033/1644 Clade B and 30/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 2/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B peptides more strongly than A/E peptides.
CTL from A/E-infected subjects stimulated by the consensus B RI8 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61539

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HXB2 Location	Gag(275-282) p24(143-150) DNA(1612..1635)	Gag Epitope Map
Author Location	p24(143-150)
Epitope	`RMYSPVSI`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag p24 RI8-6V
Subtype	CRF01_AE
Species (MHC/HLA)	human(B*52:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-724: B52:01, C01:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade A/E epitope Gag p24 RI8-6V, RMYSPVSI, was found in 1033/1644 Clade B and 30/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 2/26 A/E-infected subjects of the KI cohort. CTL induced by the clade B peptide were able to recognize clades B peptides more strongly than A/E peptides.
CTL from A/E-infected subjects stimulated by the consensus B RI8 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61540

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HXB2 Location	Gag(277-285) p24(145-153) DNA(1618..1644)	Gag Epitope Map
Author Location	p24(145-153)
Epitope	`YSPTSILDI`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag YI9
Subtype	B
Species (MHC/HLA)	human(C*01:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade B epitope Gag p24 YI9, YSPTSILDI, was found in 1032/1644 Clade B and 30/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 2/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B peptides and A/E peptides evenly.
CTL from A/E-infected subjects stimulated by the consensus B YI9 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61541

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HXB2 Location	Gag(277-285) p24(145-153) DNA(1618..1644)	Gag Epitope Map
Author Location	p24(145-153)
Epitope	`YSPVSILDI`	Epitope Alignment
		Show epitope variants
Epitope Name	Gag YI9-4V
Subtype	CRF01_AE
Species (MHC/HLA)	human(C*01:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-724: B52:01, C01:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade A/E epitope Gag p24 Gag YI9-4V, YSPVSILDI, was found in 345/1644 Clade B and 212/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 15/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clades B peptides and A/E peptides evenly.
CTL from A/E-infected subjects stimulated by the consensus B YI9 peptide used cross-recognized both clades B and A/E infected cells.

References

Displaying record number 61546

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HXB2 Location	Gag(341-349) p24(209-217) DNA(1810..1836)	Gag Epitope Map
Author Location	p24(207-219)
Epitope	`ATLEEMMTA`	Epitope Alignment
Epitope Name	Gag AA9
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-648: A*02:06
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	optimal epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Epitope Gag p24 AA9, ATLEEMMTA, is conserved between clades B and A/E and was found in 1468/1644 Clade B and 285/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 25/26 A/E-infected subjects of the KI cohort.

References

Displaying record number 61547

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HXB2 Location	Pol(282-290) RT(127-135) DNA(2928..2954)	Pol Epitope Map
Author Location	RT(127-135)
Epitope	`YTAFTIPSI`	Epitope Alignment
Epitope Name	Pol YI9
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-648: A*02:06
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	optimal epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Epitope Pol RT YI9, YTAFTIPSI, is conserved between clades B and A/E and was found in 574/1003 Clade B and 44/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in 16/26 A/E-infected subjects of the KI cohort.

References

Displaying record number 61548

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HXB2 Location	Pol(423-431) RT(268-276) DNA(3351..3377)	Pol Epitope Map
Author Location	RT(268-276)
Epitope	`SQIYAGIKV`	Epitope Alignment
Epitope Name	Pol SV9
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-964: A*02:06
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	optimal epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Epitope Pol RT SV9, SQIYAGIKV, is conserved between clades B and A/E and was found in 438/1003 Clade B and 3859 Clade A/E Los Alamos database HIV-1 sequences. It was found in 18/26 A/E-infected subjects of the KI cohort.

References

Displaying record number 61542

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HXB2 Location	Pol(595-603) RT(440-448) DNA(3867..3893)	Pol Epitope Map
Author Location	RT(440-448)
Epitope	`FYVDGAANR`	Epitope Alignment
		Show epitope variants
Epitope Name	Pol RT FR9
Subtype	B
Species (MHC/HLA)	human(A*33:03)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade B epitope Pol RT FR9, FYVDGAANR, was found in 838/1003 Clade B and 9/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in 9/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clade B FR9 peptide more strongly than the barely recognized clade A/E FR9 peptide.
CTL from A/E-infected subjects stimulated by the consensus B FR9 peptide used recognized clade B-infected but not clade A/E-infected cells.

References

Displaying record number 61543

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HXB2 Location	Pol(595-603) RT(440-448) DNA(3867..3893)	Pol Epitope Map
Author Location	RT(440-448)
Epitope	`FYVDGAASR`	Epitope Alignment
		Show epitope variants
Epitope Name	Pol RT FR9-8S
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*33:03)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-632: A24:02, A33:03
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel clade B epitope Pol RT FR9-8S, FYVDGAASR, was found in 47/1003 Clade B and 45/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in 15/26 A/E-infected subjects of the KI cohort. CTL induced by this clade B peptide were able to recognize clade B FR9 peptide more strongly than the barely recognized clade A/E FR9 peptide.
CTL from A/E-infected subjects stimulated by the consensus B FR9 peptide used recognized clade B-infected but not clade A/E-infected cells.

References

Displaying record number 61549

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HXB2 Location	Pol(767-775) Integrase(52-60) DNA(4383..4409)	Pol Epitope Map
Author Location	Integrase(50-60)
Epitope	`GQVDCSPGI`	Epitope Alignment
Epitope Name	Pol GI9
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-388: A02:06, B40:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Novel epitope Pol Integrase GI9, GQVDCSPGI, is conserved between clades B and A/E and was found in 915/1003 Clade B and 55/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in all 26 A/E-infected subjects of the KI cohort.

References

Displaying record number 61550

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HXB2 Location	Pol(809-817) Integrase(94-102) DNA(4509..4535)	Pol Epitope Map
Author Location	Integrase(94-102)
Epitope	`GQETAYFLL`	Epitope Alignment
Epitope Name	Pol GL9
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-964: A*02:06
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	optimal epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Epitope Pol Integrase GL9, GQETAYFLL, is conserved between clades B and A/E and was found in 519/1003 Clade B and 52/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in 19/26 A/E-infected subjects of the KI cohort.

References

Displaying record number 61551

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HXB2 Location	Pol(872-881) Integrase(157-166) DNA(4698..4727)	Pol Epitope Map
Author Location	Integrase(157-166)
Epitope	`ELKKIIGQVR`	Epitope Alignment
Epitope Name	Pol ER10
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*33:03)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-632: A24:02, A33:03
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	optimal epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Epitope Pol Integrase ER10, ELKKIIGQVR, is conserved between clades B and A/E and was found in 770/1003 Clade B and 40/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in 21/26 A/E-infected subjects of the KI cohort.

References

Displaying record number 61545

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HXB2 Location	Pol(912-919) Integrase(197-204) DNA(4818..4841)	Pol Epitope Map
Author Location	Integrase(197-204)
Epitope	`GERIIDII`	Epitope Alignment
		Show epitope variants
Epitope Name	Pol GI8-5I
Subtype	CRF01_AE
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-837: A02:01, B40:02
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
A previously identified consensus B epitope Pol GI8-5I, GERIIDII, was found in 378/1003 Clade B and 56/59 Clade A/E Los Alamos database HIV-1 sequences. It was found in 23/26 A/E-infected subjects of the KI cohort. CTL that recognize that consensus B GI8 peptide can recognize clade A/E GI8 peptide more strongly than clade B GI8 peptide.
CTL from A/E-infected subjects stimulated by the consensus B GI8 peptide were able to recognize cells that were both clade B-infected or clade A/E-infected.

References

Displaying record number 61544

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HXB2 Location	Pol(912-919) Integrase(197-204) DNA(4818..4841)	Pol Epitope Map
Author Location	Integrase(197-204)
Epitope	`GERIVDII`	Epitope Alignment
		Show epitope variants
Epitope Name	Pol GI8
Subtype	B
Species (MHC/HLA)	human(B*40:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
A previously identified consensus B epitope Pol GI8, GERIVDII, was found in 535/1003 Clade B and no Clade A/E Los Alamos database HIV-1 sequences. It was not found in any A/E-infected subject of the KI cohort either. CTL that recognize that consensus B GI8 peptide can recognize clade A/E GI8 peptide more strongly than clade B GI8 peptide.
CTL from A/E-infected subjects stimulated by the consensus B GI8 peptide were able to recognize cells that were both clade B-infected or clade A/E-infected.

References

Displaying record number 61525

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HXB2 Location	Nef(83-91) DNA(9043..9069)	Nef Epitope Map
Author Location	Nef(83-91)
Epitope	`GAFDLSFFL`	Epitope Alignment
		Show epitope variants
Epitope Name	Nef GL9-3F-7F
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-648: A*02:06
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade A/E epitope Nef GL9, GAFDLSFFL, was found in 12/1494 Clade B and 47/76 Clade A/E Los Alamos database HIV-1 sequences. It was found in 16/26 A/E-infected subjects of the KI cohort. CTL that recognize a consensus B GL9 peptide can cross-recognize clade A/E-infected cells.
CTL from A/E-infected subjects stimulated by the consensus B GL9 peptide used did not cross-recognize both the consensus-B and A/E peptides evenly, but more strongly recognized the clade A/E-derived peptide, GAfDLSfFL.

References

Displaying record number 61524

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HXB2 Location	Nef(83-91) DNA(9043..9069)	Nef Epitope Map
Author Location	Nef(83-91)
Epitope	`GALDLSHFL`	Epitope Alignment
		Show epitope variants
Epitope Name	Nef GL9
Subtype	B
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
A previously identified consensus B epitope Nef GL9, GALDLSHFL, was found in 529/1494 Clade B and no Clade A/E Los Alamos database HIV-1 sequences. It was found in one A/E-infected subject of the KI cohort. CTL that recognize that consensus B GL9 peptide can recognize clade A/E-infected cells but not clade B-infected cells, as strain NL4-3 clade B GL9 peptide is aAvDLSHFL, while the consensus B sequence used is GALDLSHFL.
CTL from A/E-infected subjects stimulated by the consensus B GL9 peptide used did not cross-recognize both the consensus-B and A/E peptides evenly, but more strongly recognized the clade A/E-derived peptide, GAfDLSfFL.

References

Displaying record number 61527

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HXB2 Location	Nef(134-143) DNA(9196..9225)	Nef Epitope Map
Author Location	Nef(134-143)
Epitope	`RYPLCFGWCF`	Epitope Alignment
		Show epitope variants
Epitope Name	Nef RF10-5C
Subtype	B
Species (MHC/HLA)	human(A*24:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-632: A24:02, A33:03
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade A/E epitope Nef RF10-5C, RYPLCFGWCF, was found in 94/1494 Clade B and 56/76 Clade B Los Alamos database HIV-1 sequences. It was found in 10/25 A/E-infected subjects of the KI cohort. CTL that recognize a consensus B RF10 peptide can cross-recognize clade A/E-infected cells.
CTL from A/E-infected subjects stimulated by the consensus B RF10 peptide used did cross-recognize both the consensus-B and A/E peptides evenly.

References

Displaying record number 61526

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HXB2 Location	Nef(134-143) DNA(9196..9225)	Nef Epitope Map
Author Location	Nef(134-143)
Epitope	`RYPLTFGWCF`	Epitope Alignment
		Show epitope variants
Epitope Name	Nef RF10
Subtype	B
Species (MHC/HLA)	human(A*24:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
Clade B epitope Nef RF10, RYPLTFGWCF, was found in 800/1494 Clade B and no Clade A/E Los Alamos database HIV-1 sequences. It was found in 2/25 A/E-infected subjects of the KI cohort. CTL that recognize a consensus B RF10 peptide can cross-recognize clade A/E-infected cells.
CTL from A/E-infected subjects stimulated by the consensus B RF10 peptide used did cross-recognize both the consensus-B and A/E peptides evenly.