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Displaying record number 61469

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HXB2 Location	Gag(277-285) p24(145-153) DNA(1618..1644)	Gag Epitope Map
Author Location	Gag(277-285)
Epitope	YSPVSILDI	Epitope Alignment
		Show epitope variants
Epitope Name	YI9
Subtype	CRF01_AE
Species (MHC/HLA)	human(C*01:02)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords	HLA associated polymorphism

Notes

• Significant associations between HIV-1 AE amino acids and Vietnamese HLA alleles were found to higher pVL (plasma viral load) and/or lower CD4+ T-cell counts at 8 positions in Gag and 19 positions in Pol each. HLA-AP (associated polymorphisms) were studied in 388 treatment-naive Vietnamese patients with chronic HIV-1 infection.
• Gag epitope YSPVSILDI (YI9) was the only published epitope that contained an HLA-AP detected in this study. A 4T mutant, YSPtSILDI was found to be its escape.

References

VanTran2016 Giang Van Tran, Takayuki Chikata, Jonathan M. Carlson, Hayato Murakoshi, Dung Hoai Nguyen, Yoshiko Tamura, Tomohiro Akahoshi, Nozomi Kuse, Keiko Sakai, Sachiko Sakai, Kyle Cobarrubias, Shinichi Oka, Zabrina L. Brumme, Kinh Van Nguyen, Masafumi Takiguchi, and NHTD Treatment-Naive Cohort Study Group. A Strong Association of Human Leukocyte Antigen-Associated Pol and Gag Mutations with Clinical Parameters in HIV-1 Subtype A/E Infection. AIDS, 30(5):681-689, 13 Mar 2016. PubMed ID: 26595539. Show all entries for this paper.