Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 55488

HXB2 Location	Gag(19-27) p17(19-27) DNA(844..870)	Gag Epitope Map
Author Location	p17
Epitope	IRLRPGGKK	Epitope Alignment
Epitope Name	IK9
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described HLA-B27-restricted IRLRPGGKK, were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55490

HXB2 Location	Gag(168-175) p24(36-43) DNA(1291..1314)	Gag Epitope Map
Author Location	p24
Epitope	VIPMFSAL	Epitope Alignment
Epitope Name	VL8
Subtype	B
Species (MHC/HLA)	human(Cw1)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described HLA-Cw1-restricted VIPMFSAL, were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55440

HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24
Epitope	KRWIILGLNK	Epitope Alignment
		Show epitope variants
Epitope Name	KK10
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	immunodominance, superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• Previously described epitope KRWIILGLNK is HLA-B27 restricted. Early immunodominance of the KK10-specific CTL response was followed by the stereotypical L268M escape to KRWIImGLNK and then its equivalent control via variant-specific CTLs. Variant R264K to KkWIILGLNK did not appear in the primary infection.
• Superinfection resulted in new immunodominances, a reversion to WT KK10 and later escape of the reverted WT KK10 to KkWIILGLNK (R264K), KRWIImGLNK, KRWvILGLNK and KkWIImGLNK. 2 distinct mutations accompanied this last studied escape, T239V and N252S.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55484

HXB2 Location	Vpr(31-39) DNA(5649..5675)	Vpr Epitope Map
Author Location	Vpr
Epitope	VRHFPRIWL	Epitope Alignment
Epitope Name	VL9
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described HLA-B27-restricted VRHFPRIWL, were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55486

HXB2 Location	Vpr(59-67) DNA(5733..5759)	Vpr Epitope Map
Author Location	Vpr
Epitope	AIIRILQQL	Epitope Alignment
Epitope Name	AL9
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described HLA-A2-restricted AIIRILQQL were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55487

HXB2 Location	gp160(218-226) gp120(218-226) DNA(6876..6902)	gp160 Epitope Map
Author Location	gp120
Epitope	CAPAGFAIL	Epitope Alignment
		Show epitope variants
Epitope Name	CL9
Subtype	B
Species (MHC/HLA)	human(Cw1)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	immunodominance, escape, superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• Epitope CAPAGFAIL (CL9) is previously described, with restriction to HLA-A2. Env CL9 developed variants - CtPAGFAIL at A217T that recombined the superinfecting virus to its variant sequence, CtPAGFtIL, and CtPAGFvIL.
• This epitope appears on the A list of optimal epitopes, added June 2009.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

ZunigaPerCom2008 R. Zuniga. Personal communication, 2008. Show all entries for this paper.

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Displaying record number 55493

HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41
Epitope	SLLNATAIAV	Epitope Alignment
Epitope Name	SAV10
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described HLA-A2-restricted SLLNATAIAV were seen, post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55485

HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	gp41
Epitope	IPRRIRQGL	Epitope Alignment
Epitope Name	IL9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described, HLA-B7-restricted IPRRIRQGL were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55495

HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef
Epitope	RPMTYKAAL	Epitope Alignment
Epitope Name	RL9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described, HLA-B7-restricted RPMTYKAAL were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55492

HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef
Epitope	RPMTYKAAV	Epitope Alignment
Epitope Name	RV9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described, HLA-B7-restricted RPMTYKAAV were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55489

HXB2 Location	Nef(105-115) DNA(9109..9141)	Nef Epitope Map
Author Location	Nef
Epitope	RRQDILDLWIY	Epitope Alignment
Epitope Name	RY11
Subtype	B
Species (MHC/HLA)	human(Cw7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described, HLA-Cw7-restricted RRQDILDLWIY were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55494

HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location	Nef
Epitope	YFPDWQNYT	Epitope Alignment
Epitope Name	YT9
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described, HLA-A1-restricted YFPDWQNYT were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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Displaying record number 55491

HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef
Epitope	TPGPGVRYPL	Epitope Alignment
Epitope Name	TL10
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	superinfection

Notes

• Loss of viral replication control by an elite controller after superinfection was found to coincide with rapid recombination events in 2, ~50 residue regions of Gag and Env that include immunodominant epitopes KK10 (KRWIILGLNK) and CL9 (CAPAGFAIL). Viral escape was seen at both epitopes and consequent CTL responses against the epitope-variants.
• CTL responses to previously described, HLA-B7-restricted TPGPGVRYPL were seen post-superinfection and -recombination.

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.

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