Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 1730

HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17(77-85 93TH253 subtype CRF01)
Epitope	SLYNTIATL	Epitope Alignment
Epitope Name	G77-85
Subtype	CRF01_AE
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV positive controls, and 0/9 HIV negative women that were not exposed.
• This epitope was reactive in HIV+ control study subjects 125 and 144 who carried HLA-A2.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1723

HXB2 Location	Gag(82-91) p17(82-91) DNA(1033..1062)	Gag Epitope Map
Author Location	p17(82-91 93TH253 subtype CRF01)
Epitope	IATLWCVHQR	Epitope Alignment
Epitope Name	G82-91
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in the HEPS study subject 265 who was HLA A2/A11.
• This epitope was strongly reactive in HIV+ study subject 053 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1718

HXB2 Location	Pol(248-257) RT(93-102) DNA(2826..2855)	Pol Epitope Map
Author Location	Pol(240-249 93TH253 subtype CRF01)
Epitope	GIPHPAGLKK	Epitope Alignment
Epitope Name	P248-257
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in the HEPS study subject 265 who was HLA A2/A11 and after a second stimulation in vitro gave a strong response in HEPS study subject 128 who was HLA A11/A33.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1719

HXB2 Location	Pol(272-281) RT(117-126) DNA(2898..2927)	Pol Epitope Map
Author Location	Pol(264-273 93TH253 subtype CRF01)
Epitope	SVPLDESFRK	Epitope Alignment
Epitope Name	P272-281
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope after a second stimulation in vitro gave a strong response in HEPS study subject 128 who was HLA A11/A33.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1721

HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	Pol(305-313 93TH253 subtype CRF01)
Epitope	AIFQSSMTK	Epitope Alignment
Epitope Name	P313-321
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in the HEPS study subject 128 who was HLA A11/A33.
• This epitope was strongly reactive in HIV+ study subjects 053 and 184 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1731

HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	Pol(339-347 93TH253 subtype CRF01)
Epitope	VIYQYMDDL	Epitope Alignment
Epitope Name	P334-342
Subtype	CRF01_AE
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was reactive in HIV+ control study subject 144 who carried HLA-A2.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1732

HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	Pol( 93TH253 subtype CRF01)
Epitope	ILRIPVHGV	Epitope Alignment
Epitope Name	P464-472
Subtype	CRF01_AE
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was reactive in HIV+ control study subject 144 who carried HLA-A2.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1722

HXB2 Location	Pol(495-505) RT(340-350) DNA(3567..3599)	Pol Epitope Map
Author Location	Pol(487-497 93TH253 subtype CRF01)
Epitope	QIYQEPFKNLK	Epitope Alignment
Epitope Name	P495-505
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in the HEPS study subject 128 who was HLA A11/A33.
• This epitope was reactive in HIV+ study subjects 053 and 184 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1720

HXB2 Location	Pol(571-579) RT(416-424) DNA(3795..3821)	Pol Epitope Map
Author Location	Pol(563-571 93TH253 subtype CRF01)
Epitope	FVNTPPLVK	Epitope Alignment
Epitope Name	P571-579
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in the HEPS study subject 128 who was HLA A11/A33.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1715

HXB2 Location	gp160(6-12) gp120(6-12) DNA(6240..6260)	gp160 Epitope Map
Author Location	gp120(6-15 CM243 subtype CRF01)
Epitope	TQMNWPNLWK	Epitope Alignment
Epitope Name	E6-15
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope after a second stimulation in vitro gave a weak response in HEPS study subject 186 who was HLA A2/A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1726

HXB2 Location	gp160(36-46) gp120(36-46) DNA(6330..6362)	gp160 Epitope Map
Author Location	gp120(36-46 CM243 subtype CRF01)
Epitope	VTVYYGVPVWR	Epitope Alignment
Epitope Name	E36-4
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope after a second stimulation in vitro gave a weak response in HEPS study subject 186 who was HLA A2/A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1733

HXB2 Location	gp160(191-200) gp120(191-200) DNA(6795..6824)	gp160 Epitope Map
Author Location	gp120(194-202 CM243 subtype CRF01)
Epitope	YRLINCNTSV	Epitope Alignment
Epitope Name	E191-200
Subtype	CRF01_AE
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was reactive in HIV+ control study subject 144 who carried HLA-A2.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1716

HXB2 Location	gp160(309-318) gp120(309-318) DNA(7149..7178)	gp160 Epitope Map
Author Location	gp120(314-323 CM243 subtype CRF01)
Epitope	ITVGPGQVFY	Epitope Alignment
Epitope Name	E309-318
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was strongly reactive in HIV+ control study subject 184 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1717

HXB2 Location	gp160(340-348) gp120(340-348) DNA(7242..7268)	gp160 Epitope Map
Author Location	gp120(346-354 CM243 subtype CRF01)
Epitope	RVLKQVTEK	Epitope Alignment
Epitope Name	E340-348
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in HIV+ control study subject 053 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1734

HXB2 Location	gp160(747-755) gp41(236-244) DNA(8463..8489)	gp160 Epitope Map
Author Location	gp41(741-749 CM243 subtype CRF01)
Epitope	RLVSGFLAL	Epitope Alignment
Epitope Name	E747-755
Subtype	CRF01_AE
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was reactive in HIV+ control study subject 144 who carried HLA-A2.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1729

HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41(814-823 CM243 subtype CRF01)
Epitope	SLLNATAIAV	Epitope Alignment
Epitope Name	E813-82
Subtype	CRF01_AE
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was reactive in HIV+ control study subjects 125 and 144 who carried HLA-A2.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1724

HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(71-80 93TH253 subtype CRF01)
Epitope	QVPLRPMTYK	Epitope Alignment
Epitope Name	N73-82
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in HEPS study subjects 265 who was HLA A2/A11 and 128 who was HLA A11/A33, and after a second in vitro stimulation, in study subject 256 who was HLA A11/33, making it the most reactive epitope tested in HLA-A11 HEPS women, with 3/4 responding.
• This epitope was strongly reactive in HIV+ study subject 053 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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Displaying record number 1725

HXB2 Location	Nef(83-92) DNA(9043..9072)	Nef Epitope Map
Author Location	Nef(81-90 93TH253 subtype CRF01)
Epitope	GAFDLSFFLK	Epitope Alignment
Epitope Name	N83-92
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was strongly reactive in HIV+ study subjects 053 and 184 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.

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