Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 1481

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160( IIIB)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords	Th1, Th2

Vaccine Details

Vaccine type	vaccinia
Vaccine strain	B clade IIIB
Vaccine component	gp160

Notes

Helicobacter pylori induces Th1 responses early, but predominantly Th2 responses later in infection (at 6 weeks) -- differentiation of HIV-1 gp160 CD4+ help and CD8+ CTL effector cells in response to HIV gp160-vaccinia vaccination is impaired in BALB/c mice infected with H. pylori.

References

Shirai2001 M. Shirai, R. Fujinaga, T. Masaki, and J. A. Berzofsky. Impaired development of HIV-1 gp160-specific CD8(+) cytotoxic T cells by a delayed switch from Th1 to Th2 cytokine phenotype in mice with Helicobacter pylori infection. Eur. J. Immunol., 31(2):516-26, Feb 2001. PubMed ID: 11180117. Show all entries for this paper.