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- Molecularly cloned primary NSI macrophage tropic strain 2.1 and SI non-macrophage tropic strain 1.2 were isolated from study participant ACH320 and use to infect irradiated XID mice that had been reconstituted with human PBMC from B14+ seronegative donors -- results indicate CTL may favor selective outgrowth of macrophage tropic strains.
- The CTL clone TCC108 specific for SAEPVPLQL, previously described by van Baalen 1997, and van Baalen 1998, was stimulated in vitro and given to the mice to apply specific CTL pressure.
- The macrophage-tropic HIV-1 strain #2.1 escaped CTL pressure more efficiently (7/14 animals) than its non-macrophage-tropic counterpart #1.2(SI) -- the latter isolate was suppressed in 13/14 animals -- macrophage may serve as a CTL sanctuary and reduced pressure on macrophage tropic HIV strains may allow additional replication to assist with acquisition of escape.
- Specific HIV-1 variants selectively induced by TCC108 were for strain 1.2: SEEPVPLQL, and for strain 2.1: SAEHVPLQL, SAESVPLQL, SVEPVPLQL, SLEPVPLQL, SAEPVPFQL, and SAEPVPFQL.
M. Schutten, C. A. van Baalen, C. Guillon, R. C. Huisman, P. H. Boers, K. Sintnicolaas, R. A. Gruters, and A. D. Osterhaus. Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure. J. Virol., 75(6):2706-9, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/6/2706. PubMed ID: 11222694.
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