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Displaying record number 58376

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location
Epitope	`RGPGRAFVTI`	Epitope Alignment
Epitope Name	H, P18-I10
Subtype	A
Species (MHC/HLA)	mouse(H-2D^d)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Intracellular cytokine staining
Keywords	mother-to-infant transmission, vaccine antigen design

Vaccine Details

Vaccine type	Bacillus BCG prime with vaccinia Ankara (MVA) boost
Vaccine strain	A clade, multiple epitope immunogen
Vaccine component	p17 Gag, p24 Gag, other

Notes

The HIVA polyprotein contains p24, p17, and a polyepitope string of conserved epitopes. A candidate vaccine was constructed with Mycobacterium bovis bacillus Calmette-Guerin (BCG) as the vector. When mice were primed with BCG-HIVA and boosted with MVA-HIVA, the frequencies of HIV-specific CD8+ T cells producing IFN-γ were higher in adult mice vaccinated intradermally compared to newborn mice or adults vaccinated subcutaneously. HIV-specific CTL activity was higher in newborn mice than in adults. This method may provide a model for bivalent vaccination against infant HIV-1 and tuberculosis.
Epitope H (P18-I10) was used to assess the immunogenicity of the HIVA immunizations.

References

Saubi2011 Narcis Saubi, Eung-Jun Im, Raquel Fernández-Lloris, Olga Gil, Pere-Joan Cardona, Josep Maria Gatell, Tomáš Hanke, and Joan Joseph. Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes. Clin. Dev. Immunol., 2011:516219, 2011. PubMed ID: 21603216. Show all entries for this paper.