Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 53856

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HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	Gag(169-177)
Epitope	EVIPMFSAL	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding, Other
Keywords	subtype comparisons, immunodominance, optimal epitope

Notes

• Reverse immunogenetics was used to identify HIV-1 epitopes presented by HLA-A*2601. 110 peptides were predicted to bind to HLA-A*2601. 24 of these were demonstrated to bind through a HLA-A*2601 stabilization assay. Four of these, including this one, were shown to be epitopes endogenously presented by this allele, that can induce peptide-specific CD8 T-cells. HLA-A*2601 is common in Asia.
• Immunodominant epitope recognized in 5/7 HIV-infected individuals with HLA-A*2601. This epitope is highly conserved in clade B and E (CRF01).

References

Satoh2005 Manami Satoh, Yuji Takamiya, Shinichi Oka, Katsushi Tokunaga, and Masafumi Takiguchi. Identification and Characterization of HIV-1-Specific CD8+ T Cell Epitopes Presented by HLA-A*2601. Vaccine, 23(29):3783-3790, 31 May 2005. PubMed ID: 15893615. Show all entries for this paper.

Displaying record number 53857

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HXB2 Location	Pol(604-612) RT(449-457) DNA(3894..3920)	Pol Epitope Map
Author Location	Pol(604-612)
Epitope	ETKLGKAGY	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding, Other
Keywords	immunodominance, characterizing CD8+ T cells, optimal epitope

Notes

• Reverse immunogenetics was used to identify HIV-1 epitopes presented by HLA-A*2601. Four epitopes endogenously presented by this allele induced peptide-specific CD8 T-cells. HIV-infected individuals predominantly detected 2 of the epitopes, which might be useful for vaccine development. HLA-A*2601 is common in Asia.
• Immunodominant epitope recognized in 4/6 HIV-infected individuals with HLA-A*2601. This epitope is highly conserved in clade E (CRF01), and moderately conserved in clade B.

References

Satoh2005 Manami Satoh, Yuji Takamiya, Shinichi Oka, Katsushi Tokunaga, and Masafumi Takiguchi. Identification and Characterization of HIV-1-Specific CD8+ T Cell Epitopes Presented by HLA-A*2601. Vaccine, 23(29):3783-3790, 31 May 2005. PubMed ID: 15893615. Show all entries for this paper.

Displaying record number 53855

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HXB2 Location	Pol(647-656) RT(492-501) DNA(4023..4052)	Pol Epitope Map
Author Location	Pol(647-656)
Epitope	EVNIVTDSQY	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding, Other
Keywords	immunodominance, optimal epitope

Notes

• Reverse immunogenetics was used to identify HIV-1 epitopes presented by HLA-A*2601. 110 peptides were predicted to bind to HLA-A*2601. 24 of these were demonstrated to bind through a HLA-A*2601 stabilization assay. Four of these, including this one, were shown to be epitopes endogenously presented by this allele, that can induce peptide-specific CD8 T-cells. HLA-A*2601 is common in Asia.
• This epitope was recognized in only 1/7 HLA-A*2601 HIV infected individuals.

References

Satoh2005 Manami Satoh, Yuji Takamiya, Shinichi Oka, Katsushi Tokunaga, and Masafumi Takiguchi. Identification and Characterization of HIV-1-Specific CD8+ T Cell Epitopes Presented by HLA-A*2601. Vaccine, 23(29):3783-3790, 31 May 2005. PubMed ID: 15893615. Show all entries for this paper.

Displaying record number 53854

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HXB2 Location	gp160(466-475) gp120(466-475) DNA(7620..7649)	gp160 Epitope Map
Author Location	Env(464-473)
Epitope	EVFRPGGGDM	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding, Other
Keywords	immunodominance, optimal epitope

Notes

• Reverse immunogenetics was used to identify HIV-1 epitopes presented by HLA-A*2601. 110 peptides were predicted to bind to HLA-A*2601. 24 of these were demonstrated to bind through a HLA-A*2601 stabilization assay. Four of these, including this one, were shown to be epitopes endogenously presented by this allele, that can induce peptide-specific CD8 T-cells.HLA-A*2601 is common in Asia.
• This epitope was recognized in only 1/7 HLA-A*2601 HIV infected individuals.

References

Satoh2005 Manami Satoh, Yuji Takamiya, Shinichi Oka, Katsushi Tokunaga, and Masafumi Takiguchi. Identification and Characterization of HIV-1-Specific CD8+ T Cell Epitopes Presented by HLA-A*2601. Vaccine, 23(29):3783-3790, 31 May 2005. PubMed ID: 15893615. Show all entries for this paper.