HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 701

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(302-312 HXB2)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Safrit1994b J. T. Safrit, A. Y. Lee, C. A. Andrews, and R. A. Koup. A Region of the Third Variable Loop of HIV-1 gp120 Is Recognized by HLA-B7-Restricted CTLs from Two Acute Seroconversion Patients. J. Immunol., 153:3822-3830, 1994. HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope was defined, RPNNNTRKSI, with anchor residues at the proline and isoleucine; the anchor residues are relatively well conserved. A Serine to Arginine change at position 9 of the epitope abrogated clone recognition in one of the patients. This amino acid change is one factor that has been associated with a change from a nonsyncytium-inducing to a syncytium-inducing phenotype of HIV-1.. PubMed ID: 7523505. Show all entries for this paper.


Displaying record number 865

HXB2 Location gp160(770-780)
gp41(259-269)
DNA(8532..8564)
gp160 Epitope Map
Author Location gp41(770-780 BH10)
Epitope RLRDLLLIVTR Epitope Alignment
RLRDLLLIVTR epitope logo
Species (MHC/HLA) human(A*3101)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Safrit1994a J. T. Safrit, C. A. Andrews, T. Zhu, D. D. Ho, and R. A. Koup. Characterization of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocyte Clones Isolated during Acute Seroconversion: Recognition of Autologous Virus Sequences within a Conserved Immunodominant Epitope. J. Exp. Med., 179:463-472, 1994. HIV-1 specific CTL clones were isolated from two individuals at acute seroconversion. In one patient, two HLA A31-restricted clones recognized the same fragment of gp41, peptide RLRDLLLIVTR, but one was sensitive to a Thr to Val substitution, while the other was not. A CTL HLA A32-restricted clone from the other patient recognized the gp41 peptide VLSIVNRVRQGYSPLSFQTH. Autologous viral sequences from seroconversion were recognized by the CTL clones, but not the HIV-1 strain MN. PubMed ID: 8294860. Show all entries for this paper.

Safrit1994b J. T. Safrit, A. Y. Lee, C. A. Andrews, and R. A. Koup. A Region of the Third Variable Loop of HIV-1 gp120 Is Recognized by HLA-B7-Restricted CTLs from Two Acute Seroconversion Patients. J. Immunol., 153:3822-3830, 1994. HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope was defined, RPNNNTRKSI, with anchor residues at the proline and isoleucine; the anchor residues are relatively well conserved. A Serine to Arginine change at position 9 of the epitope abrogated clone recognition in one of the patients. This amino acid change is one factor that has been associated with a change from a nonsyncytium-inducing to a syncytium-inducing phenotype of HIV-1.. PubMed ID: 7523505. Show all entries for this paper.


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