Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 55339

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	Gag
Epitope	`SLYNTVATL`	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to epitope SL9, SLYNTVATL, a patient with oscillating ART had IFN-gamma secretion by CD127 lo cells during viremia and CD127hi cell-IFN-gamma production during viremic control. Shortly after ART cessation, CD127 mixed cells secreted IFN-gamma. HLA-restriction was to -A2.

References

Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.

Displaying record number 55332

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(162-172)
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to epitope KF11, KAFSPEVIPMF, IFN-gamma was produced by CD127 lo cells by both controllers and chronic patients. IL-2 and TNF-alpha were produced by both CD127 hi and lo cells in controllers. HLA-restriction was to -B*57.

References

Displaying record number 55334

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(131-140)
Epitope	`KRWIILGLNK`	Epitope Alignment
Epitope Name	KK10
Subtype	B
Species (MHC/HLA)	human(B*27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to epitope KK10, KRWIILGLNK, IFN-gamma was produced by CD127 lo cells in chronic patients without viremia. IL-2 and TNF-alpha were not secreted. In patients with early ART, IFN-gamma was secreted by both CD127 hi and lo cells before treatment but was maintained in CD127 hi cells after treatment. CD127 hi cells were responsible for producing IL-2 and TNF-alpha after ART. HLA-restriction to KK10 was -B*27.

References

Displaying record number 55341

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HXB2 Location	Vif(61-69) DNA(5221..5247)	Vif Epitope Map
Author Location	Vif
Epitope	`DAKLIITTY`	Epitope Alignment
Epitope Name	Vif-DY9
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	HIV-1 infection
Patient MHC/HLA	A02, A03, B35, B51
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to epitope DY9, DAKLIITTY, a patient with oscillating ART had IFN-gamma secretion by CD127 lo cells during viremia and CD127hi cell-IFN-gamma production during viremic control. Shortly after ART cessation, CD127 mixed cells secreted IFN-gamma. HLA-restriction is to -B*35.

References

Displaying record number 55337

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HXB2 Location	gp160(841-855) gp41(330-344) DNA(8745..8789)	gp160 Epitope Map
Author Location	Env(837-851)
Epitope	`LHIPTRIRQGLERAL`	Epitope Alignment
Epitope Name	EE211
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to peptide EE211, LHIPTRIRQGLERAL, a patient with early ART had IFN-gamma secretion by both CD127 hi and lo cells before treatment but was maintained in CD127 hi cells after treatment. CD127 hi cells were responsible for producing IL-2 and TNF-alpha after ART.

References

Displaying record number 55335

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HXB2 Location	Nef(29-43) DNA(8881..8925)	Nef Epitope Map
Author Location	Nef(29-43)
Epitope	`GVGAVSRDLEKHGAI`	Epitope Alignment
Epitope Name	GI-15 or Nef8
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to peptide GI-15, IFN-gamma and IL-2 were produced by CD127 hi cells in patients given early ART . TNF-alpha was secreted by CD127 lo cells. Longitudinally, in one patient, IFN-gamma was secreted by both CD127 hi and lo cells before treatment but was maintained in CD127 hi cells after treatment. CD127 hi cells were responsible for producing IL-2 and TNF-alpha after ART.

References

Displaying record number 55333

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HXB2 Location	Nef(90-97) DNA(9064..9087)	Nef Epitope Map
Author Location	Nef(89-96)
Epitope	`FLKEKGGL`	Epitope Alignment
Epitope Name	FL8
Subtype	B
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to epitope FL8, FLKEKGGL, IFN-gamma and TNF-alpha were produced by CD127 lo cells in chronic patients with viremia. IL-2 was produced by both CD127 hi and lo cells. HLA-restriction was to -B*8.

References

Displaying record number 55340

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HXB2 Location	Nef(122-141) DNA(9160..9219)	Nef Epitope Map
Author Location	Nef
Epitope	`PDWQNYTPGPGVRYPLTFGW`	Epitope Alignment
Epitope Name	Nef13 (containing epitope TL10)
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to peptide Nef13, containing epitope TL10, TPGPGVRYPL, a patient with oscillating ART had IFN-gamma secretion by CD127 lo cells during viremia and CD127hi cell-IFN-gamma production during viremic control. Shortly after ART cessation, CD127 mixed cells secreted IFN-gamma. TL10 HLA-restriction is to -B*35.

References

Displaying record number 55336

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HXB2 Location	Nef(128-136) DNA(9178..9204)	Nef Epitope Map
Author Location	Nef(128-136)
Epitope	`TPGPGVRYP`	Epitope Alignment
Epitope Name	TP9
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
In response to epitope TP9, TPGPGVRYP, IFN-gamma was produced by CD127 mix cells in patients with chronic infection and viremia. Chronically infected patients with low VL did not secrete IFN-gamma. HLA-restriction was to -B*07.