HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 83

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 195

HXB2 Location Gag(183-191)
p24(51-59)
DNA(1336..1362)
Gag Epitope Map
Author Location p24
Epitope DLNTMLNTV Epitope Alignment
DLNTMLNTV epitope logo
Show epitope variants
Species (MHC/HLA) human(B14, Cw8)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 322

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFWKTLRA Epitope Alignment
DRFWKTLRA epitope logo
Show epitope variants
Species (MHC/HLA) human(B14)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 333

HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Show epitope variants
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 463

HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords review, subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 467

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMMDL Epitope Alignment
VIYQYMMDL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 517

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 574

HXB2 Location Pol(651-660)
RT(496-505)
DNA(4035..4064)
Pol Epitope Map
Author Location RT
Epitope VTDSQYALGI Epitope Alignment
VTDSQYALGI epitope logo
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 819

HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 991

HXB2 Location Nef(74-81)
DNA(9016..9039)
Nef Epitope Map
Author Location Nef
Epitope VPLRPMTY Epitope Alignment
VPLRPMTY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 1054

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Show epitope variants
Species (MHC/HLA) human(B7)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 1069

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Show epitope variants
Species (MHC/HLA) human(B49)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 1095

HXB2 Location Nef(190-198)
DNA(9364..9390)
Nef Epitope Map
Author Location Nef(190-198 LAI)
Epitope AFHHVAREL Epitope Alignment
AFHHVAREL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

Connan1994 F. Connan, F. Hlavac, J. Hoebeke, J. G. Guillet, and J. Choppin. A Simple Assay for Detection of Peptides Promoting the Assembly of HLA Class I Molecules. Eur. J. Immunol., 24:777-780, 1994. Peptides from influenza and HIV-1 were tested for their ability to promote the assembly of HLA-A2 and HLA-B51 molecules in T2 cell lysates. HIV Pol 476-484 allowed significant assembly of HLA-A2, and is a target for CTL. Nef peptide 186-194 produced significant assembly of HLA-B51. A hydrophobic anchor residue (V, L, I) at position 9 could occupy pocket F, and a hydrophobic residue (V, L) at position 3 or 4 may anchor to hydrophobic pocket D of HLA-B51. Proline at position 2 increases HLA-B51 anchoring. PubMed ID: 8125145. Show all entries for this paper.

Hadida1995 F. Hadida, G. Haas, G. Zimmermann, A. Hosmalin, R. Spohn, A. Samri, G. Jung, P. Debre, and B. Autran. CTLs from Lymphoid Organs Recognize an Optimal HLA-A2 Restricted and HLA-B52 Restricted Nonapeptide and Several Epitopes in the C-Terminal Region of HIV-1 Nef. J. Immunol., 154:4174-4186, 1995. An in vitro limiting dilution analysis showed CTL recognition in the context of HLA B52 and A2.1, A2.2 and A2.4 in nanomolar concentrations. Molecular modeling suggests motifs important for peptide binding to the pocket of an HLA-A2.1 molecule. PubMed ID: 7535824. Show all entries for this paper.

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


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