HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 59061

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17
Epitope GGKKKYKMK Epitope Alignment
GGKKKYKMK epitope logo
Subtype HIV-2
Species (MHC/HLA) human(B*35)
Immunogen HIV-2 infection
Country Gambia, Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV-2

Notes

References

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 48

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 128

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen  
Experimental methods  
Keywords  

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 182

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location p24
Epitope TPQDLNQML Epitope Alignment
TPQDLNQML epitope logo
Species (MHC/HLA) human(B53)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Gotch1993 F. Gotch, S. N. McAdam, and C. E. Allsopp et al. Cytotoxic T Cells in HIV-2 Seropositive Gambians. Identification of a Virus-Specific MHC-Restricted Peptide Epitope. J. Immunol., 151:3361-3369, 1993. PubMed ID: 7690804. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 212

HXB2 Location Gag(203-212)
p24(71-80)
DNA(1396..1425)
Gag Epitope Map
Author Location p24
Epitope EIINEEAAEW Epitope Alignment
EIINEEAAEW epitope logo
Subtype HIV-2
Species (MHC/HLA) human(A*25)
Immunogen HIV-2 infection
Country Gambia, Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV-2

Notes

References

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.

vanBaalen1996 C. A. van Baalen, M. R. Klein, R. C. Huisman, M. E. Dings, S. R. Kerkhof Garde, A. M. Geretti, R. Gruters, C. A. van Els, F. Miedema, and A. D. Osterhaus. Fine-Specificity of Cytotoxic T Lymphocytes Which Recognize Conserved Epitopes of the Gag Protein of Human Immunodeficiency Virus Type 1. J. Gen. Virol., 77:1659-1665, 1996. PubMed ID: 8760412. Show all entries for this paper.


Displaying record number 244

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen  
Experimental methods  
Keywords  

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 284

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 293

HXB2 Location Gag(263-277)
p24(131-145)
DNA(1576..1620)
Gag Epitope Map
Author Location p24(265-279)
Epitope KRWIILGLNKIVRMY Epitope Alignment
KRWIILGLNKIVRMY epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Nixon1990 D. F. Nixon, S. Huet, J. Rothbard, M.-P. Kieny, M. Delchambre, C. Thiriart, C. R. Rizza, F. M. Gotch, and A. J. McMichael. An HIV-1 and HIV-2 Cross-Reactive Cytotoxic T Cell Epitope. AIDS, 4:841-845, 1990. An HLA-B27 specific CTL clone from an HIV-1 infected individual that reacts with the Gag SF2 epitope KRWIILGLNKIVRMY also cross-reacts with the HIV-2 ROD analog RRWIQIGLQKSVRMY. The CTL also reacts with HIV-1 ELI KRWIIVGLNKIVRMY and SIVmm142 RRWIQLGLQKSVRMY, but only at very high concentration of peptide with SIVk6w78 RRWIQLRLQKSVRMY. The binding of the SIVk6w78 peptide to HLA-B27 does not seem to be reduced, so the authors suggest that the reduced ability to stimulate is in this case due to T-cell receptor interaction. PubMed ID: 1701304. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 329

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFYKLTRA Epitope Alignment
DRFYKLTRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 465

HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol
Epitope HPDIVIYQY Epitope Alignment
HPDIVIYQY epitope logo
Species (MHC/HLA) human(B35)
Immunogen  
Experimental methods  
Keywords  

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 59064

HXB2 Location gp160(376-383)
gp120(376-383)
DNA(7350..7373)
gp160 Epitope Map
Author Location gp120
Epitope TNCRGEFL Epitope Alignment
TNCRGEFL epitope logo
Subtype HIV-2
Species (MHC/HLA) human(Cw*04)
Immunogen HIV-2 infection
Country Gambia, Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV-2

Notes

References

Johnson1993 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Recognition of a Highly Conserved Region of Human Immunodeficiency Virus Type 1 gp120 by an HLA-Cw4-Restricted Cytotoxic T-Lymphocyte Clone. J. Virol., 67:438-445, 1993. The epitope sequence FNCGGEFF stimulates CTL response; the natural variants FNCRGEFF (SF2), TNCRGEFL (ROD) and LNCGGEFF (NDK) do not serve as epitopes. This was the first report of an HIV antigen specific target cells restricted by an HLA-C molecule, Cw4. PubMed ID: 7677956. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 781

HXB2 Location gp160(376-383)
gp120(376-383)
DNA(7350..7373)
gp160 Epitope Map
Author Location gp120(376-383)
Epitope FNCGGEFF Epitope Alignment
FNCGGEFF epitope logo
Species (MHC/HLA) human(Cw4)
Immunogen HIV-1 infection
Country Gambia
Experimental methods  
Keywords variant cross-reactivity

Notes

References

Johnson1993 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Recognition of a Highly Conserved Region of Human Immunodeficiency Virus Type 1 gp120 by an HLA-Cw4-Restricted Cytotoxic T-Lymphocyte Clone. J. Virol., 67:438-445, 1993. The epitope sequence FNCGGEFF stimulates CTL response; the natural variants FNCRGEFF (SF2), TNCRGEFL (ROD) and LNCGGEFF (NDK) do not serve as epitopes. This was the first report of an HIV antigen specific target cells restricted by an HLA-C molecule, Cw4. PubMed ID: 7677956. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 59063

HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope EKYLQDQAR Epitope Alignment
EKYLQDQAR epitope logo
Subtype HIV-2
Species (MHC/HLA) human(B*14)
Immunogen HIV-2 infection
Country Gambia, Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV-2

Notes

References

Johnson1992 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Identification of Overlapping HLA Class I-Restricted Cytotoxic T Cell Epitopes in a Conserved Region of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Definition of Minimum Epitopes and Analysis of the Effects of Sequence Variation. J. Exp. Med., 175:961-971, 1992. Fine mapping and mutational analysis of gp41 epitopes: ERYLKDQQL, HLA B14 and YLKDQQLL, HLA B8. PubMed ID: 1372650. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 844

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41
Epitope YLQDQARL Epitope Alignment
YLQDQARL epitope logo
Subtype HIV-2
Species (MHC/HLA) human(B*08)
Immunogen HIV-2 infection
Country Gambia, Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV-2

Notes

References

Johnson1992 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Identification of Overlapping HLA Class I-Restricted Cytotoxic T Cell Epitopes in a Conserved Region of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Definition of Minimum Epitopes and Analysis of the Effects of Sequence Variation. J. Exp. Med., 175:961-971, 1992. Fine mapping and mutational analysis of gp41 epitopes: ERYLKDQQL, HLA B14 and YLKDQQLL, HLA B8. PubMed ID: 1372650. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 996

HXB2 Location Nef(74-81)
DNA(9016..9039)
Nef Epitope Map
Author Location Nef
Epitope VPLRPMTY Epitope Alignment
VPLRPMTY epitope logo
Species (MHC/HLA) human(B35)
Immunogen  
Experimental methods  
Keywords  

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


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