Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 54965

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HXB2 Location	Gag(215-223) p24(83-91) DNA(1432..1458)	Gag Epitope Map
Author Location	Gag(215-223)
Epitope	`LHPVHAGPI`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, LHPVHAGPI, is similar to human protein PTPRE, sequence LnPVHAGPIV and human protein T cell leukemia Homeobox 1, sequence LHPgHAePIV.

References

Rolland2007a Morgane Rolland, David C. Nickle, Wenjie Deng, Nicole Frahm, Christian Brander, Gerald H. Learn, David Heckerman, Nebosja Jojic, Vladimir Jojic, Bruce D. Walker, and James I. Mullins. Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins. PLoS ONE, 2(9):e823, 2007. PubMed ID: 17786195. Show all entries for this paper.

Displaying record number 54967

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HXB2 Location	Gag(291-300) p24(159-168) DNA(1660..1689)	Gag Epitope Map
Author Location	Gag(291-300)
Epitope	`EPFRDYVDRF`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, EPFRDYVDRF, is similar to human protein COPINE 5, sequence vPFRDYVDR.

References

Displaying record number 54966

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HXB2 Location	Gag(328-336) p24(196-204) DNA(1771..1797)	Gag Epitope Map
Author Location	Gag(328-336)
Epitope	`PDCKTILKA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, PDCKTILKA, is similar to human protein Deltex 4 homolog, sequence HPDCKTI.

References

Displaying record number 54968

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HXB2 Location	Pol(212-221) RT(57-66) DNA(2718..2747)	Pol Epitope Map
Author Location	Pol(209-221)
Epitope	`NTPVFAIKKK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, NTPVFAIKKK, is similar to human protein HERV, sequence SPwNTPVFvIKKK.

References

Displaying record number 54969

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HXB2 Location	Pol(319-327) RT(164-172) DNA(3039..3065)	Pol Epitope Map
Author Location	Pol(319-327)
Epitope	`MTKILEPFR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, MTKILEPFR, is similar to human protein Piwi-like 2, sequence MTKILEPc and human protein SON DNA Binding protein, sequence sMTKILdsF.

References

Displaying record number 54970

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HXB2 Location	Pol(501-509) RT(346-354) DNA(3585..3611)	Pol Epitope Map
Author Location	Pol(501-508)
Epitope	`FKNLKTGKY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, FKNLKTGKY, is similar to human protein Str Spe Recognition protein, sequence FKNsKTG.

References

Displaying record number 54971

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HXB2 Location	Pol(648-657) RT(493-502) DNA(4026..4055)	Pol Epitope Map
Author Location	Pol(648-657)
Epitope	`VNIVTDSQYA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, VNIVTDSQYA, is similar to human protein HERV, sequence VNIyTDSQYA and human protein Thrombospondin 3 precursor, sequence VNtVTDddYA.

References

Displaying record number 54972

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HXB2 Location	Pol(798-806) Integrase(83-91) DNA(4476..4502)	Pol Epitope Map
Author Location	Pol(798-806)
Epitope	`YIEAEVIPA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, YIEAEVIPA, is similar to an unnamed human protein, sequence gYIEAaVIPAG and human protein p53 inducible protein, sequence EIEAEV.

References

Displaying record number 54976

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HXB2 Location	Vpr(7-15) DNA(5577..5603)	Vpr Epitope Map
Author Location	Vpr(7-15)
Epitope	`DQGPQREPY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, DQGPQREPY, is similar to human protein Carcinoma associated protein, sequence qRP-DQGPQRPP, and human proline-rich protein, sequence DQGPQRpP.

References

Displaying record number 54977

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HXB2 Location	Tat(18-26) DNA(5882..5908)	Tat Epitope Map
Author Location	Tat(18-26)
Epitope	`PKTACTNCY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, PKTACTNCY, is similar to human protein Zinc finger protein, sequence SQPKsACgNCY.

References

Displaying record number 54980

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HXB2 Location	Rev(10-18) DNA(5997..6023)	Rev Epitope Map
Author Location	Rev(10-18)
Epitope	`EELLKTVRL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, EELLKTVRL, is similar to human protein nucleolar RNA associated protein, sequence EELLKeVRL, and a human protein, sequence LLKTVRLlRLL.

References

Displaying record number 54979

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HXB2 Location	Vpu(7-15) DNA(6080..6106)	Vpu Epitope Map
Author Location	Vpu(7-15)
Epitope	`LAIVALVVA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, LAIVALVVA, is similar to human protein Trypsin-domain protein, sequence alVALVVApL, and human small inducible cytokine 28 protein, sequence LAIVALaV.

References

Displaying record number 54974

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HXB2 Location	gp160(478-486) gp120(478-486) DNA(7656..7682)	gp160 Epitope Map
Author Location	Env(469-477)
Epitope	`NWRSELYKY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, NWRSELYKY, is similar to human protein peroxysomal acylcoA thioestherase, sequence hNWRSELY.

References

Displaying record number 54975

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HXB2 Location	Nef(15-23) DNA(8839..8865)	Nef Epitope Map
Author Location	Nef(15-23)
Epitope	`TVRERMRRA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, TVRERMRRA, is similar to human protein Rhomboid protein, sequence TTVRsRMRRA.

References

Displaying record number 54978

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HXB2 Location	Nef(101-109) DNA(9097..9123)	Nef Epitope Map
Author Location	Nef(101-109)
Epitope	`IYSQKRQDI`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
This HIV-1 epitope, IYSQKRQDI, is similar to human protein Ig heavy chain variable region, sequence tYSQKfQDI.