Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 53426

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HXB2 Location	gp160(308-322) gp120(308-322) DNA(7146..7190)	gp160 Epitope Map
Author Location	gp140( iiib)
Epitope	RIQRGPGRAFTIGK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	mouse
Immunogen	vaccine
Patient MHC/HLA	H-2d
Experimental methods	Chromium-release assay, Proliferation
Keywords	adjuvant comparison

Vaccine Details

Notes

• Mice were immunized with gp140 and an adjuvant that was an oil-in -water emulsion containing liposomes with lipid A with encapsulated antigen. Stable and unstable emulsions were found to have similar potencies of inducing antigen-specific T-cell proliferation and IgG antibodies, but stable emulsions also induced antigen-specific CTL responses. Stable emulsions had lowered IgG2a/IgG1 ratios than unstable.

References

Richards2004 Roberta L. Richards, Mangala Rao, Thomas C. Vancott, Gary R. Matyas, Deborah L. Birx, and Carl R. Alving. Liposome-Stabilized Oil-in-Water emulsions as Adjuvants: Increased Emulsion Stability Promotes Induction of Cytotoxic T Lymphocytes against an HIV Envelope Antigen. Immunol. Cell Biol., 82(5):531-8, Oct 2004. PubMed ID: 15479439. Show all entries for this paper.