Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 53832

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag(147-155)
Epitope	ISPRTLNAW	Epitope Alignment
		Show epitope variants
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	epitope processing, responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• ISPRTLNAW is the C consensus form of the epitope and was the autologous form in the mother, and was transmitted to her infant. By 33 weeks a new dominant form of the epitope had emerged in the infant, mSPRTLNAW, and two additional variants had arisen, one with a substitution proximal to the epitope, plSPRTLNAW, and lSPRTLNAW.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.

Displaying record number 53833

HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag(240-249)
Epitope	TSTLQEQIAW	Epitope Alignment
		Show epitope variants
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• TSTLQEQIAW is the C consensus form of the epitope and the autologous form in the mother was TSTLQEQItW, and this was the form transmitted to her infant. The mother does not carry B57, and the B57 escape footprint was inherited paternally. By 33 weeks a new dominant form of the epitope had emerged in the infant, TSnLQEQIAW, and the consensus form was also present in the infant.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.

Displaying record number 53834

HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag(263-272)
Epitope	KRWIILGLNK	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Country	Barbados
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• A B27 escape footprint was passed from a B27+ father to his partner, who then passed the variant to their child. KRWIILGLNK is the B consensus form of this epitope, the paternal form was KqWIIiGLNK, the maternal form, KqWvImGLNK, and this was the form passed on to the child.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.

Displaying record number 53828

HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(73-82)
Epitope	QVPLRPMTYK	Epitope Alignment
		Show epitope variants
Subtype	C
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*0301, A*7401, B*1510, B*3501, Cw*0401; A*0301, A*68, B*0702, B*1510, Cw*0401, Cw*0702
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• QVPLRPMTYK is the C subtype consensus form of an epitope recognized in a mother, who carried this autologous variant: QVPLRPMTfK. QVPLRPMTfK was the dominant form in her infant at 2 weeks of age, but new variants rapidly emerged: QVPLkPMTfK, QVPLRPMnYK, QVPvRPMTfK, QVPLRPMsYr, QVPLRPMsYK.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.

Displaying record number 53831

HXB2 Location	Nef(82-90) DNA(9040..9066)	Nef Epitope Map
Author Location	Nef(82-90)
Epitope	KAAFDLSFF	Epitope Alignment
		Show epitope variants
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• KAAFDLSFF is the C consensus form of the epitope; the autologous form in the mother was KAAFDLgFF, and this was transmitted to her infant. By 33 weeks a new dominant form of the epitope had emerged in the infant: gAAFDLgFF.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.

Displaying record number 53830

HXB2 Location	Nef(116-124) DNA(9142..9168)	Nef Epitope Map
Author Location	Nef(116-124)
Epitope	HTQGYFPDW	Epitope Alignment
		Show epitope variants
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• HTQGYFPDW is the C consensus form of the epitope; the autologous form in the mother was HTQGfFPDW, and this was transmitted to her infant. By 33 weeks a new dominant form of the epitope had emerged in the infant: nTQGfFPDW.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.

Displaying record number 53829

HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef(128-137)
Epitope	TPGPGVRYPL	Epitope Alignment
		Show epitope variants
Subtype	C
Species (MHC/HLA)	human(B*4201)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*30, A*3001, B*1503, B*4201, Cw*0202, Cw*1701; A*0301, A*3001, B*4201, B*5802, Cw*0602, Cw*1701
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

• HIV-specific CTLs in infants were shown to be able to select for viral escape variants early in life, despite a lack of escape with the same CTL specificity in the mother. Infant CTL responses may be compromised by transmission of escape variants that arose in the mother and also those that arose in the father, if the father was the source of the mother's infection.
• Escape variants tSgpgvrypl and tQgpgvrypl were rapidly selected in an infant, by 26 weeks, but were not found in the infant's mother. These forms were demonstrated to be escape mutations by Elispot, and also had reduced binding to B*4201 in a competitive inhibition assay.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.