Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 52294

HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17(77-85 LAI)
Epitope	SLYNTVATL	Epitope Alignment
Epitope Name	LR23
Subtype	B
Species (MHC/HLA)	mouse(A*0201)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses, immunodominance

Vaccine Details

Notes

• When HIV-1 peptides were used to vaccinate HLA-A2.1 transgenic A2-Kb mice, strong responses to five peptides were observed when the peptides were given individually, but immunodominance limited the response to some of the peptides when they were given in combination Peter2001. IL-12 can counteract immunodominance in BALB/c mice, so it was given with the multiple epitope vaccination, and was instead found to specifically eliminate the HLA-A2.1-epitope CTL responses, but not Kb CTL responses. This was possibly a consequence of transient depletion of T-cells, B cells and macropahges in the spleen.

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.

Displaying record number 52297

HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	RT(346-354 LAI)
Epitope	VIYQYMDDL	Epitope Alignment
Epitope Name	LR26
Subtype	B
Species (MHC/HLA)	mouse(A*0201)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses, immunodominance

Vaccine Details

Notes

• When HIV-1 peptides were used to vaccinate HLA-A2.1 transgenic A2-Kb mice, strong responses to five peptides were observed when the peptides were given individually, but immunodominance limited the response to some of the peptides when they were given in combination Peter2001. IL-12 can counteract immunodominance in BALB/c mice, so it was given with the multiple epitope vaccination, and was instead found to specifically eliminate the HLA-A2.1-epitope CTL responses, but not Kb CTL responses. This was possibly a consequence of transient depletion of T-cells, B cells and macropahges in the spleen.

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.

Displaying record number 52292

HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT(476-484 LAI)
Epitope	ILKEPVHGV	Epitope Alignment
Epitope Name	LR22
Subtype	B
Species (MHC/HLA)	mouse(A*0201)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses, immunodominance

Vaccine Details

Notes

• When HIV-1 peptides were used to vaccinate HLA-A2.1 transgenic A2-Kb mice, strong responses to five peptides were observed when the peptides were given individually, but immunodominance limited the response to some of the peptides when they were given in combination Peter2001. IL-12 can counteract immunodominance in BALB/c mice, so it was given with the multiple epitope vaccination, and was instead found to specifically eliminate the HLA-A2.1-epitope CTL responses, but not Kb CTL responses. This was possibly a consequence of transient depletion of T-cells, B cells and macropahges in the spleen.

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.

Displaying record number 52301

HXB2 Location	Pol(956-964) Integrase(241-249) DNA(4950..4976)	Pol Epitope Map
Author Location	RT(956-964 HXB2R)
Epitope	LLWKGEGAV	Epitope Alignment
Epitope Name	LR28
Subtype	B
Species (MHC/HLA)	mouse(A*0201)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses, immunodominance

Vaccine Details

Notes

• When HIV-1 peptides were used to vaccinate HLA-A2.1 transgenic A2-Kb mice, strong responses to five peptides were observed when the peptides were given individually, but immunodominance limited the response to some of the peptides when they were given in combination Peter2001. IL-12 can counteract immunodominance in BALB/c mice, so it was given with the multiple epitope vaccination, and was instead found to specifically eliminate the HLA-A2.1-epitope CTL responses, but not Kb CTL responses. This was possibly a consequence of transient depletion of T-cells, B cells and macropahges in the spleen.

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.

Displaying record number 52299

HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41(814-823 LAI)
Epitope	SLLNATDIAV	Epitope Alignment
Epitope Name	LR27
Subtype	B
Species (MHC/HLA)	mouse(A*0201)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses, immunodominance

Vaccine Details

Notes

• When HIV-1 peptides were used to vaccinate HLA-A2.1 transgenic A2-Kb mice, strong responses to five peptides were observed when the peptides were given individually, but immunodominance limited the response to some of the peptides when they were given in combination Peter2001. IL-12 can counteract immunodominance in BALB/c mice, so it was given with the multiple epitope vaccination, and was instead found to specifically eliminate the HLA-A2.1-epitope CTL responses, but not Kb CTL responses. This was possibly a consequence of transient depletion of T-cells, B cells and macropahges in the spleen.

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.