Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 61629

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag(147-155)
Epitope	ISPRTLNAW	Epitope Alignment
		Show epitope variants
Epitope Name	ISW9
Subtype	B
Species (MHC/HLA)	human(B*57:03)
Immunogen	HIV-1 infection
Country	Barbados, Botswana, Spain, United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords	subtype comparisons, variant cross-reactivity

Notes

• Response to KF11 in B*5703-positive subtype C-infected subjects is associated with a lower viral setpoint, while response in B*5701-positive B-infected subjects is associated with a 10-fold higher viral setpoint. This difference seems to depend strongly on the residue at Gag173.
• ISPRTLNAW was in the region of the KF11 epitope and its I147X escape mutation was associated with HLA-B*5703 in B-infected subjects of the Barbados cohort.

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.

Displaying record number 59380

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag(162-172)
Epitope	KAFSPEVIPMF	Epitope Alignment
		Show epitope variants
Epitope Name	KF11
Subtype	B, C
Species (MHC/HLA)	human(B*57:01, B*57:03)
Immunogen	HIV-1 infection
Country	Barbados, Botswana, Spain, United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords	subtype comparisons, variant cross-reactivity

Notes

• Response to KF11 in B*5703-positive subtype C-infected subjects is associated with a lower viral setpoint, while response in B*5701-positive B-infected subjects is associated with a 10-fold higher viral setpoint. This difference seems to depend strongly on the residue at Gag173.
• B-infected B*5701-positive KF11 responders have a higher viral setpoint than non-responders.
• Escape variants A163G and S165N are selected in ˜70% of C-infected B*5703-positive subjects, but are not found in B-infected B*5703-positive subjects i.e. not associated with B*5703.

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.

Displaying record number 61630

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag(240-249)
Epitope	TSTLQEQIGW	Epitope Alignment
		Show epitope variants
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B*57:03)
Immunogen	HIV-1 infection
Country	Barbados, Botswana, Spain, United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords	subtype comparisons, variant cross-reactivity

Notes

• Response to KF11 in B*5703-positive subtype C-infected subjects is associated with a lower viral setpoint, while response in B*5701-positive B-infected subjects is associated with a 10-fold higher viral setpoint. This difference seems to depend strongly on the residue at Gag173.
• TSTLQEQIGW was in the region of the KF11 epitope and its T242N escape mutation was associated with HLA-B*5703 in B-infected subjects of the Barbados cohort.

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.

Displaying record number 59381

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HXB2 Location	Pol(530-538) RT(375-383) DNA(3672..3698)	Pol Epitope Map
Author Location	Gag(162-172)
Epitope	IATESIVIW	Epitope Alignment
Epitope Name	IAW9
Subtype	B, C
Species (MHC/HLA)	human(B*57:01, B*57:03)
Immunogen	HIV-1 infection
Country	Barbados, Botswana, Spain, United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords	subtype comparisons, variant cross-reactivity

Notes

• Response to KF11 in B*5703-positive subtype C-infected subjects is associated with a lower viral setpoint, while response in B*5701-positive B-infected subjects is associated with a 10-fold higher viral setpoint. This difference seems to depend strongly on the residue at Gag173.
• IATESIVIW was used as a control to show that B*5703-restricted IAW9-specific T cells had no differences in the level of stimulation by wild type NL43 versus Gag-S173T mutant NL43.

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.