Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 61454

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HXB2 Location	Nef(17-25) DNA(8845..8871)	Nef Epitope Map
Author Location	Nef(17-25)
Epitope	RERMRRAEP	Epitope Alignment
		Show epitope variants
Epitope Name	Nef17-25
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada, Peru, United States
Experimental methods	Other
Keywords	vaccine-induced immune responses, escape

Notes

• Vaccine-enhanced viral escape of the STEP trial was documented in this study in 4 Nef epitopes. A mathematical model (Shifted Poisson Mixture Model, SPMM, Love et al.) was used to designate patients infected with a single founder virus; and Gag, Pol and Nef were studied for differences in escape between vaccinated and placebo-treated groups.
• Marginally significant (p = 0.065) increase was seen in Nef epitope RERMRRAEP escape/diversity for STEP-vaccine administered patients (0/22 placebo patients vs. 5/29 vaccine-primed patients).

References

Park2016a Sung Yong Park, Wendy J Mack, and Ha Y Lee. Enhancement of viral escape in HIV-1 Nef by STEP vaccination. AIDS, 30(16):2449-2458, Oct 23 2016. PubMed ID: 27427874. Show all entries for this paper.

Displaying record number 61453

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HXB2 Location	Nef(65-76) DNA(8989..9024)	Nef Epitope Map
Author Location	Nef(65-76)
Epitope	EVGFPVRPQVPL	Epitope Alignment
		Show epitope variants
Epitope Name	Nef65-76
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada, Peru, United States
Experimental methods	Other
Keywords	vaccine-induced immune responses, escape

Notes

• Vaccine-enhanced viral escape of the STEP trial was documented in this study in 4 Nef epitopes. A mathematical model (Shifted Poisson Mixture Model, SPMM, Love et al.) was used to designate patients infected with a single founder virus; and Gag, Pol and Nef were studied for differences in escape between vaccinated and placebo-treated groups.
• Significant (p = 0.0038) increases were seen in immunodominant epitope EVGFPVRPQVPL escape/diversity for STEP-vaccine administered patients (1/22 placebo patients vs. 6/29 vaccine-primed patients).

References

Park2016a Sung Yong Park, Wendy J Mack, and Ha Y Lee. Enhancement of viral escape in HIV-1 Nef by STEP vaccination. AIDS, 30(16):2449-2458, Oct 23 2016. PubMed ID: 27427874. Show all entries for this paper.

Displaying record number 61455

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HXB2 Location	Nef(166-174) DNA(9292..9318)	Nef Epitope Map
Author Location	Nef(166-174)
Epitope	HPMSQHGIE	Epitope Alignment
		Show epitope variants
Epitope Name	Nef166-174
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada, Peru, United States
Experimental methods	Other
Keywords	vaccine-induced immune responses, escape

Notes

• Vaccine-enhanced viral escape of the STEP trial was documented in this study in 4 Nef epitopes. A mathematical model (Shifted Poisson Mixture Model, SPMM, Love et al.) was used to designate patients infected with a single founder virus; and Gag, Pol and Nef were studied for differences in escape between vaccinated and placebo-treated groups.
• Marginally significant (p = 0.065) increase was seen in Nef epitope HPMSQHGIE escape/diversity for STEP-vaccine administered patients (0/22 placebo patients vs. 7/29 vaccine-primed patients).

References

Park2016a Sung Yong Park, Wendy J Mack, and Ha Y Lee. Enhancement of viral escape in HIV-1 Nef by STEP vaccination. AIDS, 30(16):2449-2458, Oct 23 2016. PubMed ID: 27427874. Show all entries for this paper.

Displaying record number 61456

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HXB2 Location	Nef(174-184) DNA(9316..9348)	Nef Epitope Map
Author Location	Nef(174-184)
Epitope	EDPEKEVLEWR	Epitope Alignment
		Show epitope variants
Epitope Name	Nef174-184
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada, Peru, United States
Experimental methods	Other
Keywords	vaccine-induced immune responses, escape

Notes

• Vaccine-enhanced viral escape of the STEP trial was documented in this study in 4 Nef epitopes. A mathematical model (Shifted Poisson Mixture Model, SPMM, Love et al.) was used to designate patients infected with a single founder virus; and Gag, Pol and Nef were studied for differences in escape between vaccinated and placebo-treated groups.
• Marginally significant (p = 0.083) increase was seen in Nef epitope EDPEKEVLEWR escape/diversity for STEP-vaccine administered patients (0/22 placebo patients vs. 7/29 vaccine-primed patients).

References

Park2016a Sung Yong Park, Wendy J Mack, and Ha Y Lee. Enhancement of viral escape in HIV-1 Nef by STEP vaccination. AIDS, 30(16):2449-2458, Oct 23 2016. PubMed ID: 27427874. Show all entries for this paper.