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Displaying record number 52765

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160( IIIB)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Epitope Name	P18-I10
Subtype	B
Species (MHC/HLA)	mouse(H-2D^d)
Immunogen	vaccine
Patient MHC/HLA	H-2d
Experimental methods	CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding
Keywords

Vaccine Details

Vaccine type	vaccinia
Vaccine strain	B clade IIIB
Vaccine component	Env V3
Adjuvant	B7, ICAM, LFA-3

Notes

BALB/c mice were vaccinated with T-cell depleted splenocytes pulsed with peptides given in combination with immunostimulatory molecules B7, ICAM or LFA expressed in a recombinant pox virus. Increasing antigen gave an increased frequency of CD8+ T-cells, but the co-stimulatory molecules increased the avidity of the response.

References

Oh2003b SangKon Oh, James W Hodge, Jeffrey D Ahlers, Donald S Burke, Jeffrey Schlom, and Jay A Berzofsky. Selective Induction of High Avidity CTL by Altering the Balance of Signals from APC. J. Immunol., 170(5):2523-2530, Mar 2003. PubMed ID: 12594278. Show all entries for this paper.