Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 57230

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HXB2 Location	Gag(141-155) p24(9-23) DNA(1210..1254)	Gag Epitope Map
Author Location	Gag(141-155)
Epitope	`QMVHQAISPRTLNAW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
This peptide, containing HLA-B*5801-restricted epitope, ISPRTLNAW, elicited a response in the subject on day 221 post-infection.

References

OConnell2009 Karen A. O'Connell, Jie Xu, Anna P. Durbin, Linda G. Apuzzo, Hejab Imteyaz, Thomas M. Williams, Stuart C. Ray, Joseph B. Margolick, Robert F. Siliciano, and Joel N. Blankson. HIV-1 Evolution Following Transmission to an HLA-B*5801-Positive Patient. J. Infect. Dis., 200(12):1820-1824, 15 Dec 2009. PubMed ID: 19909081. Show all entries for this paper.

Displaying record number 57231

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HXB2 Location	Gag(157-171) p24(25-39) DNA(1258..1302)	Gag Epitope Map
Author Location	Gag(157-171)
Epitope	`KVVEEKAFSPEVIPM`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
This peptide elicited a response in the subject on day 221 post-infection. Although it contained partial HLA-B*57/58-restricted epitope, KAFSPEVIPMF, it was not able to respond to that optimal epitope.

References

Displaying record number 57186

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag(240-249)
Epitope	`TSTLQEQIGW`	Epitope Alignment
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, mutation acquisition, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Gag epitope TSTLQEQIGW escaped to TSnLQEQIGW (T242N) by day 67 in the HLA-B*5810 host. Other variants seen were TS-LpEQIGW and TSTLpEQIGW. The subject was able to respond to peptide AGTTSTLQEQIGWMT on day 221.

References

Displaying record number 57233

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HXB2 Location	Gag(301-315) p24(169-183) DNA(1690..1734)	Gag Epitope Map
Author Location	Gag(301-315)
Epitope	`YKTLRAEQASQEVKN`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
This peptide containing a partial epitope, QASQEVKN, elicited a response in the subject on day 221 post-infection. An overlapping peptide containing the complete optimal HLA-B*5801-restricted peptide QASQEVKNW did not elicit response, though response to the optimal epitope itself was seen 2 years post-infection.

References

Displaying record number 57237

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HXB2 Location	Gag(471-479) p2p7p1p6(108-116) DNA(2200..2226)	Gag Epitope Map
Author Location	Gag(471-479)
Epitope	`TPSQKQEPI`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A33:03:01, B42:01, B53:01:01
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, viral fitness and reversion, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope TPSQKQEPI did not elicit a response in the subject on day 221 post-infection. A P478S mutation to TPSQKQEsI in the subject, and TPSQKQEPt in the transmitter that reverted to TPSQKQEPI in subject were seen. Putative HLA-restriction was B*53 carried by the transmitter.

References

Displaying record number 57238

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HXB2 Location	Gag(477-486) p2p7p1p6(114-123) DNA(2218..2247)	Gag Epitope Map
Author Location	Gag(477-486)
Epitope	`EPIDKELYPL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A33:03:01, B42:01, B53:01:01
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope EPIDKELYPL did not elicit a response in the subject on day 221 post-infection. A P478S mutation to EsIDKELYPL in the subject, and EPtDKELYPL in the transmitter that reverted to EPIDKELYPL in subject were seen. Putative HLA-restriction was B*53 carried by the transmitter.

References

Displaying record number 57239

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HXB2 Location	Gag(484-492) p2p7p1p6(121-129) DNA(2239..2265)	Gag Epitope Map
Author Location	Gag(484-492)
Epitope	`YPLASLRSL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A33:03:01, B42:01, B53:01:01
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope YPLASLRSL did not elicit a response in the subject on day 221 post-infection. YPLASLkSL in the transmitter that reverted to YPLASLRSL in subject was seen. Putative HLA-restriction was B*53 carried by the transmitter.

References

Displaying record number 57242

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HXB2 Location	Pol(328-338) RT(173-183) DNA(3066..3098)	Pol Epitope Map
Author Location	RT(177-183)
Epitope	`KQNPDIVIYQY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A33:03:01, B42:01, B53:01:01; A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope KQNPDIVIYQY did not elicit a response in the subject on day 221 post-infection. A K177E mutation to eQNPDIVIYQY in the subject was seen. Putative HLA-restriction was A*30 carried by both the transmitter and subject.

References

Displaying record number 57232

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HXB2 Location	Pol(397-411) RT(242-256) DNA(3273..3317)	Pol Epitope Map
Author Location	RT(242-256)
Epitope	`QPIVLPEKDSWTVND`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
This peptide containing HLA-B*5801-restricted epitope, IVLPEKDSW, elicited a response in the subject on day 221 post-infection.

References

Displaying record number 57234

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HXB2 Location	Pol(525-539) RT(370-384) DNA(3657..3701)	Pol Epitope Map
Author Location	RT(370-384)
Epitope	`EAVQKIATESIVIWG`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
This peptide containing HLA-B*5801-restricted epitope, KIATESIVIW, elicited a response in the subject on day 221 post-infection.

References

Displaying record number 57243

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HXB2 Location	Pol(589-602) RT(434-447) DNA(3849..3890)	Pol Epitope Map
Author Location	RT(434-447)
Epitope	`IVGAETFYVDGAAN`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope IVGAETFYVDGAAN did not elicit a response in the subject on day 221 post-infection. A V435A mutation to IaGAETFYVDGAAN in the subject was seen. Putative HLA-restriction was A*6802, carried by the subject.

References

Displaying record number 57205

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HXB2 Location	Pol(838-847) Integrase(123-132) DNA(4596..4625)	Pol Epitope Map
Author Location	Integrase(123-132)
Epitope	`STTVKAACWW`	Epitope Alignment
Epitope Name	SW9
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, mutation acquisition, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Integrase epitope STTVKAACWW escaped to SamVKAACWW (T125M) by day 137. Another variant seen was SaTVKAACWW. CTL response to the peptide GSNFTSTTVKAACWW (Gag 118-132), containing epitope SW10 was seen by day 221.

References

Displaying record number 57240

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HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	Env(298-307)
Epitope	`RPNNNTRKSI`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A33:03:01, B42:01, B53:01:01
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope RPNNNTRKSI did not elicit a response in the subject on day 221 post-infection. RPNNNTRKgI in the transmitter that reverted to RPNNNTRKSI in subject was seen. Putative HLA-restriction was B*42 carried by the transmitter.

References

Displaying record number 57241

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HXB2 Location	gp160(794-802) gp41(283-291) DNA(8604..8630)	gp160 Epitope Map
Author Location	Env(794-802)
Epitope	`KYWWNLLQY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A33:03:01, B42:01, B53:01:01; A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Epitope KYWWNLLQY did not elicit a response in the subject on day 221 post-infection. A K794R mutation to rYWWNLLQY in the subject was seen. Putative HLA-restriction was A*30 carried by both the transmitter and subject.

References

Displaying record number 57204

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HXB2 Location	Nef(82-90) DNA(9040..9066)	Nef Epitope Map
Author Location	Nef(82-90)
Epitope	`KAAVDLSHF`	Epitope Alignment
Epitope Name	KF9
Subtype	B
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, mutation acquisition, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Nef epitope KAAVDLSHF variants KgAVDlSHF (A83G), KAAlDLSHF (V85L) and the rare KAAVDLSHl (F90L) were seen by day 221. None of these elicited CTL response.

References

Displaying record number 57235

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HXB2 Location	Nef(101-115) DNA(9097..9141)	Nef Epitope Map
Author Location	Nef(101-115)
Epitope	`IYSQKRQDILDLWVY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A30:01:01, A68:01:01, B58:01, B58:02
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, acute/early infection, elite controllers

Notes

Full genome and longitudinal sequence analyses were performed on a transmission pair from transmission on, to determine the extent of B*5801-restricted epitope mutations as compared to other HIV-1 epitope variations. Although escape was rapid in HLA-B*5801-restricted epitopes in 3 proteins, relative control of viral replication was maintained. The protective effect of HLA allele B*5801 superseded the presence of rapid disease progression-associated HLA allele B*5802.
Peptide IYSQKRQDILDLWVY elicited a response in the subject on day 221 post-infection. A V114I mutation to IYSQKRQDILDLWiY was seen.