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Displaying record number 280

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(263-272)
Epitope	KRWIILGLNK	Epitope Alignment
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords	review, escape

Notes

• Single point mutations were introduced and viral viability and CTL recognition tested -- an Arg to Lys change at anchor position P2 abrogates binding to B27, but doesn't change viral viability in vitro.
• Goulder1997e is a review of immune escape that summarizes this study.

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Nietfeld1995 W. Nietfeld, M. Bauer, M. Fevrier, R. Maier, B. Holzwarth, R. Frank, B. Maier, Y. Riviere, and A. Meyerhans. Sequence Constraints and Recognition by CTL of an HLA-B27-Restricted HIV-1 Gag Epitope. J. Immunol., 154:2188-2197, 1995. Single point mutations were introduced into this epitope in the viral strain LAI, and the ability of comparable peptides to sensitize target strains was tested. The change of anchor residue R 264 to (L or G), results in infectious virus, and corresponding peptide has reduced binding affinities for HLA-B27. The change of G 267 to K or E abrogated infectivity, and the peptide bound to HLA-B27, but did not serve as a target; thus nonrecognition of peptides derived from quasispecies analysis of a small region might not really be associated with an escape mutant, but rather a non-viable mutant. PubMed ID: 7868892. Show all entries for this paper.