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Displaying record number 280

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Nietfeld1995 W. Nietfeld, M. Bauer, M. Fevrier, R. Maier, B. Holzwarth, R. Frank, B. Maier, Y. Riviere, and A. Meyerhans. Sequence Constraints and Recognition by CTL of an HLA-B27-Restricted HIV-1 Gag Epitope. J. Immunol., 154:2188-2197, 1995. Single point mutations were introduced into this epitope in the viral strain LAI, and the ability of comparable peptides to sensitize target strains was tested. The change of anchor residue R 264 to (L or G), results in infectious virus, and corresponding peptide has reduced binding affinities for HLA-B27. The change of G 267 to K or E abrogated infectivity, and the peptide bound to HLA-B27, but did not serve as a target; thus nonrecognition of peptides derived from quasispecies analysis of a small region might not really be associated with an escape mutant, but rather a non-viable mutant. PubMed ID: 7868892. Show all entries for this paper.


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