Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 1351

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	Env( IIIB)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Epitope Name	I-10
Subtype	B
Species (MHC/HLA)	mouse(H-2D^d)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords	epitope processing, immunodominance, optimal epitope

Notes

The CTL line LINE-IIIB was generated by repetitive restimulation of BALB/c spleen cells with vSC-25, IIIB gp160-expressing vaccinia.
RGPGRAFVTI represents the active minimal epitope within the previously described immunodominant epitope P18IIIB (RIQRGPGRAFVTIGK, gp160(308-322)).
External processing of P18IIIB results in the removal of the 2 C-terminal residues (GK) of I-10 by ACE (angiotensin-1-converting-enzyme) in sera to produce I-10, and this processing is essential for target cell presentation of RIQRGPGRAFVTIGK.

References

Nakagawa2000 Y. Nakagawa, T. Takeshita, J. A. Berzofsky, and H. Takahashi. Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes. Immunology, 101(1):76-82, Sep 2000. PubMed ID: 11012756. Show all entries for this paper.