Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 277

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(265-274)
Epitope	KRWIILGLNK	Epitope Alignment
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dynamics, TCR usage

Notes

• In one individual, TCR usage changed over time indicating that new populations of CTL can be recruited.
• TCR usage showed a CTL clonal response to this epitope that persisted over 5 years.
• CTL clones specific for HIV epitopes may represent between 0.2 and 1% of the total CD8+ population of T cells.

References

Moss1995 P. A. H. Moss, S. L. Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. McMichael, and J. I. Bell. Persistent High Frequency of Human Immunodeficiency Virus-Specific Cytotoxic T Cells in Peripheral Blood of Infected Donors. Proc. Natl. Acad. Sci. U.S.A., 92:5773-5777, 1995. PubMed ID: 7597028. Show all entries for this paper.

Displaying record number 525

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT(309-317)
Epitope	ILKEPVHGV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	TCR usage

Notes

• Two clones were obtained with different TCR usage, V_beta1 and V_beta21.

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Moss1995 P. A. H. Moss, S. L. Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. McMichael, and J. I. Bell. Persistent High Frequency of Human Immunodeficiency Virus-Specific Cytotoxic T Cells in Peripheral Blood of Infected Donors. Proc. Natl. Acad. Sci. U.S.A., 92:5773-5777, 1995. PubMed ID: 7597028. Show all entries for this paper.