Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 52065

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	RT(128-135 IIIB)
Epitope	TAFTIPSI	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, escape

Notes

• HIV polymorphisms in the RT protein were examined relation to HLA alleles found in a population of 473 participants in the Western Australian HIV Cohort Study. 64 significant associations between polymorphisms at particular positions and HLA alleles were detected, for HLA-B7, -B12, -B35 and -B15. Fifteen of these were in positions with known epitopes, 4 in anchor residues, 11 in other positions. Six additional polymorphic sites associated with particular HLA molecules flanked known epitopes and may relate to processing.
• TAFTIPSI was one of two epitopes characterized in detail. C-terminal I135x substitutions were associated with people who carried HLA-B5 -- 39/40 (98%) of HLA-B*5101 individuals had substitutions in this position, while only 127/431 (29%) who did not have HLA-B*5101 did. The predominant substitution was kytaftipsT, and this mutation is predicted to abrogate binding to HLA-B*5101.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.

Displaying record number 52069

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HXB2 Location	Pol(311-320) RT(156-165) DNA(3015..3044)	Pol Epitope Map
Author Location	RT( IIIB)
Epitope	SPAIFQSSMT	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, escape

Notes

• HIV polymorphisms in the RT protein were examined relation to HLA alleles found in a population of 473 participants in the Western Australian HIV Cohort Study. 64 significant associations between polymorphisms at particular positions and HLA alleles were detected, for HLA-B7, -B12, -B35 and -B15. Fifteen of these were in positions with known epitopes, 4 in anchor residues, 11 in other positions. Six additional polymorphic sites associated with particular HLA molecules flanked known epitopes and may relate to processing.
• HLA-B7+ individuals with a S162x (18/33) substitution had higher viral loads than those that did not, suggesting escape was associated with diminished immune control of viremia.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.

Displaying record number 52068

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	RT(158-166 IIIB)
Epitope	AIFQSSMTK	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, escape

Notes

• HIV polymorphisms in the RT protein were examined relation to HLA alleles found in a population of 473 participants in the Western Australian HIV Cohort Study. 64 significant associations between polymorphisms at particular positions and HLA alleles were detected, for HLA-B7, -B12, -B35 and -B15. Fifteen of these were in positions with known epitopes, 4 in anchor residues, 11 in other positions. Six additional polymorphic sites associated with particular HLA molecules flanked known epitopes and may relate to processing.
• HLA-A11+ individuals with a K166x (4/19) substitution had higher viral loads than those that did not, suggesting escape was associated with diminished immune control of viremia.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.

Displaying record number 52066

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HXB2 Location	Pol(330-338) RT(175-183) DNA(3072..3098)	Pol Epitope Map
Author Location	RT(175-183 IIIB)
Epitope	NPDIVIYQY	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B*35:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, escape

Notes

• HIV polymorphisms in the RT protein were examined relation to HLA alleles found in a population of 473 participants in the Western Australian HIV Cohort Study. 64 significant associations between polymorphisms at particular positions and HLA alleles were detected, for HLA-B7, -B12, -B35 and -B15. Fifteen of these were in positions with known epitopes, 4 in anchor residues, 11 in other positions. Six additional polymorphic sites associated with particular HLA molecules flanked known epitopes and may relate to processing.
• NPDIVIYQY was one of two epitopes characterized in detail. D177x substitutions are known to specifically abrogate binding to HLA-B*3501, and not other B*35 subtypes. D177x substitutions were associated with people who carried HLA-B*3501 and not other B*35 subtypes; considering high resolution typing generally strengthened the B*35 associations.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.

Displaying record number 52067

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Notes

• HIV polymorphisms in the RT protein were examined relation to HLA alleles found in a population of 473 participants in the Western Australian HIV Cohort Study. 64 significant associations between polymorphisms at particular positions and HLA alleles were detected, for HLA-B7, -B12, -B35 and -B15. Fifteen of these were in positions with known epitopes, 4 in anchor residues, 11 in other positions. Six additional polymorphic sites associated with particular HLA molecules flanked known epitopes and may relate to processing.
• 25 negative associations were also found between polymorphism and HLA alleles. The authors propose this is due to escape mutations in epitopes presented by common HLA types dominating in the population, and give examples of five amino acids which are in the consensus and tend to be stable in those with the most common HLA allele, HLA-A2.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.