HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 59 matching records:

Displaying record number 404

HXB2 Location Pol(173-181)
RT(18-26)
DNA(2601..2627)
Pol Epitope Map
Author Location RT(173-181)
Epitope GPKVKQWPL Epitope Alignment
GPKVKQWPL epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 403

HXB2 Location Pol(173-181)
RT(18-26)
DNA(2601..2627)
Pol Epitope Map
Author Location RT(18-26)
Epitope GPKVKQWPL Epitope Alignment
GPKVKQWPL epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Meier1995 U.-C. Meier, P. Klenerman, P. Griffin, W. James, B. Koppe, B. Larder, R. E. Phillips, A. J. McMichael, and R. E. Phillips. Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants. Science, 270:1360-1362, 1995. HIV bearing mutations in epitope allowed transactive inhibition of specific CTL mediated lysis. Therefore, mutations in epitopes may not only allow escape from specific CTL, but enhance the ability of wildtype virus to persist. PubMed ID: 7481824. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 407

HXB2 Location Pol(173-181)
RT(18-26)
DNA(2601..2627)
Pol Epitope Map
Author Location RT(185-193 LAI)
Epitope GPKVKQWPL Epitope Alignment
GPKVKQWPL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1995 P. Klenerman, U.-C. Meier, R. E. Phillips, and A. J. McMichael. The Effects of Natural Altered Peptide Ligands on the Whole Blood Cytotoxic T Lymphocyte Response to Human Immunodeficiency Virus. Eur. J. Immunol., 25:1927-1931, 1995. This paper explores naturally occurring altered peptide ligands and their ability to sustain CTL, serve as antagonists to CTL specific for other variants, and to allow cell killing. The authors propose that a CTL response may be sustained in vivo that fails to recognize viral variants as they arise, proposing a mechanism for T-cell original antigenic sin. PubMed ID: 7542596. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 412

HXB2 Location Pol(193-207)
RT(38-52)
DNA(2661..2705)
Pol Epitope Map
Author Location RT(205-219 BRU)
Epitope CTEMEKEGKISKIGP Epitope Alignment
CTEMEKEGKISKIGP epitope logo
Species (MHC/HLA) mouse(H-2k)
Immunogen vaccine
Experimental methods  
Keywords review

Vaccine Details

Vaccine type protein
Vaccine strain B clade BRU
Vaccine component RT

Notes

References

DeGroot1991 A. S. De Groot, M. Clerici, A. Hosmalin, S. H. Hughes, D. Barnd, C. W. Hendrix, R. Houghten, G. M. Shearer, and J. A. Berzofsky. Human Immunodeficiency Virus Reverse Transcriptase T-Helper Epitopes Identified in Mice and Humans: Correlation with a Cytotoxic T Cell Epitope. J. Infect. Dis., 164:1058-1065, 1991. This peptide stimulates both murine helper and cytotoxic T-cells and was able to stimulate IL-2 producing T-cells from 9 out of 17 HIV seropositive humans. RT epitope: CTEMEKEGKISKIGP. PubMed ID: 1720151. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 413

HXB2 Location Pol(193-207)
RT(38-52)
DNA(2661..2705)
Pol Epitope Map
Author Location RT(205-219)
Epitope CTEMEKEGKISKIGP Epitope Alignment
CTEMEKEGKISKIGP epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Hosmalin1990 A. Hosmalin, M. Clerici, R. Houghten, C. D. Pendleton, C. Flexner, D. R. Lucey, B. Moss, R. N. Germain, G. M. Shearer, and J. A. Berzofsky. An Epitope in Human Immunodeficiency Virus 1 Reverse Transcriptase Recognized by Both Mouse and Human Cytotoxic T Lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 87:2344-2348, 1990. PubMed ID: 1690429. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 420

HXB2 Location Pol(262-270)
RT(107-115)
DNA(2868..2894)
Pol Epitope Map
Author Location RT(262-270 IIIB)
Epitope TVLDVGDAY Epitope Alignment
TVLDVGDAY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, responses in children, mother-to-infant transmission

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


Displaying record number 429

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(273-282 SF2)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Show epitope variants
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 434

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302 IIIB)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 440

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(311-319 SF2)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 441

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(311-319 SF2)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 443

HXB2 Location Pol(311-320)
RT(156-165)
DNA(3015..3044)
Pol Epitope Map
Author Location RT(311-319 SF2)
Epitope SPAIFQSSMT Epitope Alignment
SPAIFQSSMT epitope logo
Species (MHC/HLA) human(B7)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Brander1997 Christian Brander and Bruce Walker. Systematic Identification of Optimal HIV-1 CTL Epitopes. In Systematic Identification of Optimal HIV-1 CTL Epitopes. pages IV--1--IV--11. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1997. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 446

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0301, A*1101, A*6801, A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Threlkeld1997 S. C. Threlkeld, P. A. Wentworth, S. A. Kalams, B. M. Wilkes, D. J. Ruhl, E. Kepgh, J. Sidney, S. Southwood, B. D. Walker, and A. Sette. Degenerate and Promiscuous Recognition by CTL of Peptides Presented by the MHC Class I A3-Like Superfamily. J. Immunol., 159(4):1648-1657, 1997. Similarities in peptide binding across A3-like superfamily results in similar peptide-MHC complex structures engaged by T-cell receptors. PubMed ID: 9257824. Show all entries for this paper.


Displaying record number 449

HXB2 Location Pol(313-321)
RT(158-166)
DNA(3021..3047)
Pol Epitope Map
Author Location RT(325-333 LAI)
Epitope AIFQSSMTK Epitope Alignment
AIFQSSMTK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Zhang1993 Q.-I. Zhang, R. Gavioli, G. Klein, and M. G. Masucci. An HLA-A11-Specific Motif in Nonamer Peptides Derived from Viral And Cellular Proteins. Proc. Natl. Acad. Sci. U.S.A., 90:2217-2221, 1993. PubMed ID: 8384718. Show all entries for this paper.


Displaying record number 461

HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(328-336 IIIB)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 459

HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(328-336 IIIB)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 463

HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords review, subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 466

HXB2 Location Pol(330-354)
RT(175-199)
DNA(3072..3146)
Pol Epitope Map
Author Location RT(342-366 LAI)
Epitope NPDIVIYQYMDDLYVGSDLEIGQHR Epitope Alignment
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walker1989 B. D. Walker, C. Flexner, K. Birch-Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. Long-Term Culture and Fine Specificity of Human Cytotoxic T-Lymphocyte Clones Reactive with Human Immunodeficiency Virus Type 1. Proc. Natl. Acad. Sci. U.S.A., 86:9514-9518, 1989. Seven HIV-1 reverse transcriptase-specific cytotoxic T-lymphocyte (CTL) clones from the peripheral blood of two seropositive subjects were generated. Five different HLA restricted CTL epitopes were identified by peptide mapping. PubMed ID: 2480604. Show all entries for this paper.


Displaying record number 473

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354 LAI)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Harrer1996 E. Harrer, T. Harrer, P. Barbosa, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of the Highly Conserved YMDD Region in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by HLA-A2-Restricted Cytotoxic T Lymphocytes from an Asymptomatic Long-Term Nonprogresser. J. Infect. Dis., 173:476-479, 1996. The amino acid stretch YMDD is a critical functional domain of reverse transcriptase, and is highly conserved. This sequence is also part of an HLA-A2-restricted epitope. The substitution YMDD to YVDD confers drug resistance to FTC and dideoxyinosine, and also abolishes the CTL specific response. PubMed ID: 8568316. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 477

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Brander1998 Christian Brander, Kelly E. Hartman, Alicja K. Trocha, Norman G. Jones, R. Paul Johnson, Bette Korber, Peggy Wentworth, Susan P. Buchbinder, Steve Wolinsky, Bruce D. Walker, and Spyros A. Kalams. Lack of Strong Immune Selection Pressure by the Immunodominant, HLA-A*0201-Restricted Cytotoxic T Lymphocyte Response in Chronic Human Immunodeficiency Virus-1 Infection. J. Clin. Invest., 101(11):2559-2566, 1 Jun 1998. PubMed ID: 9616227. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 478

HXB2 Location Pol(335-344)
RT(180-189)
DNA(3087..3116)
Pol Epitope Map
Author Location RT( LAI)
Epitope IYQYMDDLYV Epitope Alignment
IYQYMDDLYV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 481

HXB2 Location Pol(347-371)
RT(192-216)
DNA(3123..3197)
Pol Epitope Map
Author Location RT(359-383 HXB2)
Epitope DLEIGQHRTKIEELRQHLLRWGLTT Epitope Alignment
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walker1989 B. D. Walker, C. Flexner, K. Birch-Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. Long-Term Culture and Fine Specificity of Human Cytotoxic T-Lymphocyte Clones Reactive with Human Immunodeficiency Virus Type 1. Proc. Natl. Acad. Sci. U.S.A., 86:9514-9518, 1989. Seven HIV-1 reverse transcriptase-specific cytotoxic T-lymphocyte (CTL) clones from the peripheral blood of two seropositive subjects were generated. Five different HLA restricted CTL epitopes were identified by peptide mapping. PubMed ID: 2480604. Show all entries for this paper.


Displaying record number 480

HXB2 Location Pol(347-371)
RT(192-216)
DNA(3123..3197)
Pol Epitope Map
Author Location RT(191-215)
Epitope DLEIGQHRTKIEELRQHLLRWGFTT Epitope Alignment
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, escape

Notes

References

Haas1997 G. Haas, A. Hosmalin, F. Hadida, J. Duntze, P. Debre, and B. Autran. Dynamics of HIV Variants and Specific Cytotoxic T Cell Recognition in Nonprogressors and Progressors. Immunol. Lett., 57:63-68, 1997. PubMed ID: 9232427. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 483

HXB2 Location Pol(358-367)
RT(203-212)
DNA(3156..3185)
Pol Epitope Map
Author Location RT( LAI)
Epitope EELRQHLLRW Epitope Alignment
EELRQHLLRW epitope logo
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 486

HXB2 Location Pol(398-407)
RT(243-252)
DNA(3276..3305)
Pol Epitope Map
Author Location RT( LAI)
Epitope PIVLPEKDSW Epitope Alignment
PIVLPEKDSW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, escape

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 485

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT( LAI)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 490

HXB2 Location Pol(415-426)
RT(260-271)
DNA(3327..3362)
Pol Epitope Map
Author Location RT(415-426 IIIB)
Epitope LVGKLNWASQIY Epitope Alignment
LVGKLNWASQIY epitope logo
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Brander1996 Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. pages IV--50--IV--60. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1996. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 492

HXB2 Location Pol(426-434)
RT(271-279)
DNA(3360..3386)
Pol Epitope Map
Author Location RT(438-446 IIIB)
Epitope YPGIKVRQL Epitope Alignment
YPGIKVRQL epitope logo
Species (MHC/HLA) human(B42)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


Displaying record number 494

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(448-456 SF2)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B35, B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 496

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(448-456 SF2)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 497

HXB2 Location Pol(449-473)
RT(294-318)
DNA(3429..3503)
Pol Epitope Map
Author Location RT(461-485 HXB2)
Epitope PLTEEAELELAENREILKEPVHGVY Epitope Alignment
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walker1989 B. D. Walker, C. Flexner, K. Birch-Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. Long-Term Culture and Fine Specificity of Human Cytotoxic T-Lymphocyte Clones Reactive with Human Immunodeficiency Virus Type 1. Proc. Natl. Acad. Sci. U.S.A., 86:9514-9518, 1989. Seven HIV-1 reverse transcriptase-specific cytotoxic T-lymphocyte (CTL) clones from the peripheral blood of two seropositive subjects were generated. Five different HLA restricted CTL epitopes were identified by peptide mapping. PubMed ID: 2480604. Show all entries for this paper.


Displaying record number 498

HXB2 Location Pol(463-472)
RT(308-317)
DNA(3471..3500)
Pol Epitope Map
Author Location RT( LAI)
Epitope EILKEPVGHV Epitope Alignment
EILKEPVGHV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 516

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords binding affinity

Notes

References

Konya1997 J. Konya, G. Stuber, A. Bjorndal, E. M. Fenyo, and J. Dillner. Primary induction of human cytotoxic lymphocytes against a synthetic peptide of the human immunodeficiency virus type 1 protease. J. Gen. Virol., 78:2217-2224, 1997. PubMed ID: 9292009. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 510

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Ogg1998 G. S. Ogg, X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon, and A. J. McMichael. Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA. Science, 279:2103-2106, 1998. PubMed ID: 9516110. Show all entries for this paper.


Displaying record number 528

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walter1997 J. B. Walter, C. Brander, M. Mammen, D. N. Garboczi, S. A. Kalams, G. M. Whiteside, B. D. Walker, and H. N. Eisen. Stimulation of Human Cytotoxic T Cells with HIV-1-Derived Peptides Presented by Recombinant HLA-A2 Peptide Complexes. Int. Immunol., 9:451-459, 1997. HLA-A2 heavy chain and beta 2-microglobulin refolded in the presence of peptides became susceptible to lysis by HLA-A2-restricted cytotoxic T lymphocyte (CTL) clones specific for the peptides. Recombinant HLA-A2 peptide complexes covalently immobilized on microspheres stimulated the development of HLA-A2 peptide-specific CTL. PubMed ID: 9088983. Show all entries for this paper.


Displaying record number 521

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Pogue1995 R. R. Pogue, J. Eron, J. A. Frelinger, and M. Matsui. Amino-Terminal Alteration of the HLA-A*0201-Restricted Human Immunodeficiency Virus Pol Peptide Increases Complex Stability and In Vitro Immunogenicity. Proc. Natl. Acad. Sci. U.S.A., 92:8166-8170, 1995. In this mutational study a substitution of 476 I to Y did not increase affinity but did increase complex stability with HLA-A*0201. The altered peptide (Y) provided a greater stimulation of wildtype pol-specific CTL response relative to the wildtype peptide (I), in three different seropositive individuals. PubMed ID: 7545295. Show all entries for this paper.


Displaying record number 522

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 530

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Connan1994 F. Connan, F. Hlavac, J. Hoebeke, J. G. Guillet, and J. Choppin. A Simple Assay for Detection of Peptides Promoting the Assembly of HLA Class I Molecules. Eur. J. Immunol., 24:777-780, 1994. Peptides from influenza and HIV-1 were tested for their ability to promote the assembly of HLA-A2 and HLA-B51 molecules in T2 cell lysates. HIV Pol 476-484 allowed significant assembly of HLA-A2, and is a target for CTL. Nef peptide 186-194 produced significant assembly of HLA-B51. A hydrophobic anchor residue (V, L, I) at position 9 could occupy pocket F, and a hydrophobic residue (V, L) at position 3 or 4 may anchor to hydrophobic pocket D of HLA-B51. Proline at position 2 increases HLA-B51 anchoring. PubMed ID: 8125145. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 523

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Yang1996 O. O. Yang, S. A. Kalams, M. Rosenzweig, A. Trocha, N. Jones, M. Koziel, B. D. Walker, and R. P. Johnson. Efficient Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by Cytotoxic T Lymphocytes. J. Virol., 70:5799-5806, 1996. PubMed ID: 8709196. Show all entries for this paper.


Displaying record number 515

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tsomides1994 T. J. Tsomides, A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. Naturally Processed Viral Peptides Recognized by Cytotoxic T Lymphocytes on Cells Chronically Infected by Human Immunodeficiency Virus Type 1. J. Exp. Med., 180:1283-1293, 1994. Naturally processed peptides can be purified from trifluoroacetic acid lysates of HIV-1 infected cells. A gag and RT epitope were compared; both synthetic peptides are optimally active in CTL assays. The naturally processed gag peptide was more abundant than the RT peptide in HIV-1 infected HLA-A2 positive cells, and the gag specific CTL more effective, suggesting surface density of peptides may influence efficiency of CTL killing. PubMed ID: 7523570. Show all entries for this paper.


Displaying record number 518

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 525

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords TCR usage

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Moss1995 P. A. H. Moss, S. L. Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. McMichael, and J. I. Bell. Persistent High Frequency of Human Immunodeficiency Virus-Specific Cytotoxic T Cells in Peripheral Blood of Infected Donors. Proc. Natl. Acad. Sci. U.S.A., 92:5773-5777, 1995. PubMed ID: 7597028. Show all entries for this paper.


Displaying record number 527

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Musey1997 L. Musey, Y. Hu, L. Eckert, M. Christensen, T. Karchmer, and M. J. McElrath. HIV-1 Induces Cytotoxic T Lymphocytes in the Cervix of Infected Women. J. Exp. Med., 185:293-303, 1997. Mononuclear cells in cytobrush specimens from the cervical samples were stimulated with antigen. Eight women with CD4 positive counts $>=$ 500 cells/$\mu$l had HIV-1-specific CTL, but only 4/11 with counts $<$ 500 cells/$\mu$l had HIV-1-specific CTL responses. PubMed ID: 9016878. Show all entries for this paper.


Displaying record number 529

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tsomides1991 T. J. Tsomides, B. D. Walker, and H. N. Eisen. An Optimal Viral Peptide Recognized by CD8+ T Cells Binds Very Tightly to the Restricting Class I Major Histocompatibility Complex Protein on Intact Cells but Not to the Purified Class I Protein. Proc. Natl. Acad. Sci. U.S.A., 88:11276-11280, 1991. PubMed ID: 1722325. Show all entries for this paper.


Displaying record number 540

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location RT(476-485 LAI)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Subtype B
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 542

HXB2 Location Pol(483-507)
RT(328-352)
DNA(3531..3605)
Pol Epitope Map
Author Location RT(495-515 LAI)
Epitope EIQKQGQGQWTYQIYQEPFKNLKTG Epitope Alignment
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walker1989 B. D. Walker, C. Flexner, K. Birch-Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. Long-Term Culture and Fine Specificity of Human Cytotoxic T-Lymphocyte Clones Reactive with Human Immunodeficiency Virus Type 1. Proc. Natl. Acad. Sci. U.S.A., 86:9514-9518, 1989. Seven HIV-1 reverse transcriptase-specific cytotoxic T-lymphocyte (CTL) clones from the peripheral blood of two seropositive subjects were generated. Five different HLA restricted CTL epitopes were identified by peptide mapping. PubMed ID: 2480604. Show all entries for this paper.


Displaying record number 543

HXB2 Location Pol(495-505)
RT(340-350)
DNA(3567..3599)
Pol Epitope Map
Author Location RT(507-516)
Epitope QIYQEPFKNLK Epitope Alignment
QIYQEPFKNLK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Price1995 P. Price, R. P. Johnson, D. T. Scadden, C. Jassoy, T. Rosenthal, S. Kalams, and B. D. Walker. Cytotoxic CD8+ T Lymphocytes Reactive with Human Immunodeficiency Virus-1 Produce Granulocyte/Macrophage Colony-Stimulating Factor and Variable Amounts of Interleukins 2, 3, and 4 following Stimulation with the Cognate Epitope. Clin. Immunol. Immunopathol., 74:100-106, 1995. Cytokine release from stimulated CTL clones derived from either the peripheral blood or CSF of 3 patients was studied. HLA restriction was determined for two of seven clones. GM-CSF and TNF-$\alpha$ and IFN-$\gamma$ were produced by all clones; most clones produced low amounts of IL-2, IL-3, and IL-4. PubMed ID: 7527747. Show all entries for this paper.


Displaying record number 544

HXB2 Location Pol(495-507)
RT(340-352)
DNA(3567..3605)
Pol Epitope Map
Author Location RT(507-519 LAI)
Epitope QIYQEPFKNLKTG Epitope Alignment
QIYQEPFKNLKTG epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Johnson1994b R. P. Johnson and B. D. Walker. CTL in HIV-1 Infection: Responses to Structural Proteins. Curr. Topics Microbiol. Immunol., 189:35-63, 1994. Review. PubMed ID: 7523033. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 546

HXB2 Location Pol(519-527)
RT(364-372)
DNA(3639..3665)
Pol Epitope Map
Author Location RT(518-526 U455)
Epitope DVKQLTEVV Epitope Alignment
DVKQLTEVV epitope logo
Species (MHC/HLA) human(A*6802, A28)
Immunogen  
Experimental methods  
Keywords subtype comparisons

Notes

References

Dong1998 T. Dong. Personal Communication, 1998. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 548

HXB2 Location Pol(529-538)
RT(374-383)
DNA(3669..3698)
Pol Epitope Map
Author Location RT( LAI)
Epitope KITTESIVIW Epitope Alignment
KITTESIVIW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 551

HXB2 Location Pol(547-556)
RT(392-401)
DNA(3723..3752)
Pol Epitope Map
Author Location RT(559-568 LAI)
Epitope PIQKETWETW Epitope Alignment
PIQKETWETW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*3201)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 552

HXB2 Location Pol(552-561)
RT(397-406)
DNA(3738..3767)
Pol Epitope Map
Author Location RT( LAI)
Epitope TWETWWTEYW Epitope Alignment
TWETWWTEYW epitope logo
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 554

HXB2 Location Pol(587-595)
RT(432-440)
DNA(3843..3869)
Pol Epitope Map
Author Location RT(587-597 SF2)
Epitope EPIVGAETF Epitope Alignment
EPIVGAETF epitope logo
Show epitope variants
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 558

HXB2 Location Pol(587-596)
RT(432-441)
DNA(3843..3872)
Pol Epitope Map
Author Location RT(587-597 SF2)
Epitope EPIVGAETFY Epitope Alignment
EPIVGAETFY epitope logo
Species (MHC/HLA) mouse(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 560

HXB2 Location Pol(589-602)
RT(434-447)
DNA(3849..3890)
Pol Epitope Map
Author Location RT( LAI)
Epitope IVGAETFYVDGAAS Epitope Alignment
IVGAETFYVDGAAS epitope logo
Subtype B
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 561

HXB2 Location Pol(591-600)
RT(436-445)
DNA(3855..3884)
Pol Epitope Map
Author Location RT(591-600 IIIB)
Epitope GAETFYVDGA Epitope Alignment
GAETFYVDGA epitope logo
Show epitope variants
Species (MHC/HLA) human(B45)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 563

HXB2 Location Pol(592-602)
RT(437-447)
DNA(3858..3890)
Pol Epitope Map
Author Location RT(592-602 LAI)
Epitope AETFYVDGAAN Epitope Alignment
AETFYVDGAAN epitope logo
Subtype B
Species (MHC/HLA) human(A28)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Brander1996 Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. pages IV--50--IV--60. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1996. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 564

HXB2 Location Pol(593-603)
RT(438-448)
DNA(3861..3893)
Pol Epitope Map
Author Location RT(593-603 IIIB)
Epitope ETFYVDGAANR Epitope Alignment
ETFYVDGAANR epitope logo
Show epitope variants
Species (MHC/HLA) human(A26)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 567

HXB2 Location Pol(636-660)
RT(481-505)
DNA(3990..4064)
Pol Epitope Map
Author Location RT(648-672 PV22)
Epitope AIYLALQDSGLEVNIVTDSQYALGI Epitope Alignment
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kalams1994 S.A. Kalams, R. P. Johnson, A. K. Trocha, M. J. Dynan, H. S. Ngo, R. T. D'Aquila, J. T. Kurnick, and B. D. Walker. Longitudinal Analysis of T Cell Receptor (TCR) Gene Usage by HIV-1 Envelope-Specific Cytotoxic T-Lymphocyte Clones Reveals a Limited TCR Repertoire. J. Exp. Med., 179:1261-1271, 1994. This paper presents an in-depth longitudinal study of T-cell receptor gene usage to a well defined HLA B14 restricted gp41 epitope. Ten CTL clones were derived from a single individual over 31 months. T-cell receptor V-D-J sequencing was performed on PCR amplification products. All ten clones utilized V$\alpha$14 and V$\beta$4 genes; observed limited T-cell receptor diversity to an immunodominant epitope was suggested to facilitate immune escape. gp41 epitope: ERYLKDQQL. An HLA B14 restricted RT epitope from this individual used V$\alpha$21 and V$\beta$14, showing use of these genes was not a feature of all HLA B14 restricted clones from this individual. RT epitope: AIYLALQDSGLEVNIVTDSQYALGI. PubMed ID: 8145043. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 568

HXB2 Location Pol(636-660)
RT(481-505)
DNA(3990..4064)
Pol Epitope Map
Author Location RT(648-672)
Epitope AIYLALQDSGLEVNIVTDSQYALGI Epitope Alignment
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Price1995 P. Price, R. P. Johnson, D. T. Scadden, C. Jassoy, T. Rosenthal, S. Kalams, and B. D. Walker. Cytotoxic CD8+ T Lymphocytes Reactive with Human Immunodeficiency Virus-1 Produce Granulocyte/Macrophage Colony-Stimulating Factor and Variable Amounts of Interleukins 2, 3, and 4 following Stimulation with the Cognate Epitope. Clin. Immunol. Immunopathol., 74:100-106, 1995. Cytokine release from stimulated CTL clones derived from either the peripheral blood or CSF of 3 patients was studied. HLA restriction was determined for two of seven clones. GM-CSF and TNF-$\alpha$ and IFN-$\gamma$ were produced by all clones; most clones produced low amounts of IL-2, IL-3, and IL-4. PubMed ID: 7527747. Show all entries for this paper.


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