Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 54995

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HXB2 Location	Gag(197-205) p24(65-73) DNA(1378..1404)	Gag Epitope Map
Author Location	Gag( C-96BW04.09)
Epitope	AMQMLKDTI	Epitope Alignment
Epitope Name	A
Subtype	C
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	DNA, alphavirus replicon
Vaccine strain	C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component	Gag, Gag-Pol, Pol

Notes

• HIV clade C gag, pol and fusion gagpol vaccines were compared in mice. Breadth of T cell responses was improved in mice immunized with gagpol fusion genes, compared to single antigen constructs. 5 new murine CD8+ T cell epitopes were mapped.
• AMQMLKDTI has a previously identified B clade homolog AMQMLKeTI.

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.

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Displaying record number 54997

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HXB2 Location	Gag(384-392) p2p7p1p6(21-29) DNA(1939..1965)	Gag Epitope Map
Author Location	Gag( C-96BW15C05)
Epitope	KGPKRIIKC	Epitope Alignment
Epitope Name	B2
Subtype	C
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	DNA, alphavirus replicon
Vaccine strain	C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component	Gag, Gag-Pol, Pol

Notes

• HIV clade C gag, pol and fusion gagpol vaccines were compared in mice. Breadth of T cell responses was improved in mice immunized with gagpol fusion genes, compared to single antigen constructs. 5 new murine CD8+ T cell epitopes were mapped.
• This is a novel immunodominant epitope.

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.

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Displaying record number 54996

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HXB2 Location	Gag(384-392) p2p7p1p6(21-29) DNA(1939..1965)	Gag Epitope Map
Author Location	Gag( C-96BW04.09)
Epitope	KGPRRIVKC	Epitope Alignment
Epitope Name	B1
Subtype	C
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	DNA, alphavirus replicon
Vaccine strain	C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component	Gag, Gag-Pol, Pol

Notes

• HIV clade C gag, pol and fusion gagpol vaccines were compared in mice. Breadth of T cell responses was improved in mice immunized with gagpol fusion genes, compared to single antigen constructs. 5 new murine CD8+ T cell epitopes were mapped.
• This is a novel epitope.

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.

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Displaying record number 54998

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HXB2 Location	Pol(44-52) Gag/Pol-TF(44-52) DNA(2214..2240)	Pol Epitope Map
Author Location	p6(604-612 C-96BW15C05)
Epitope	AGAERQGTL	Epitope Alignment
Epitope Name	Peptide C
Subtype	C
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	DNA, alphavirus replicon
Vaccine strain	C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component	Gag, Gag-Pol, Pol

Notes

• HIV clade C gag, pol and fusion gagpol vaccines were compared in mice. Breadth of T cell responses was improved in mice immunized with gagpol fusion genes, compared to single antigen constructs. 5 new murine CD8+ T cell epitopes were mapped.
• This is a novel epitope.

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.

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Displaying record number 54999

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HXB2 Location	Pol(133-141) Protease(77-85) DNA(2481..2507)	Pol Epitope Map
Author Location	Protease( C-96BW15C05)
Epitope	IGPTPVNII	Epitope Alignment
Epitope Name	D
Subtype	C
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	DNA, alphavirus replicon
Vaccine strain	C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component	Gag, Gag-Pol, Pol

Notes

• HIV clade C gag, pol and fusion gagpol vaccines were compared in mice. Breadth of T cell responses was improved in mice immunized with gagpol fusion genes, compared to single antigen constructs. 5 new murine CD8+ T cell epitopes were mapped.
• This is a novel epitope.

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.

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Displaying record number 55000

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HXB2 Location	Pol(314-322) RT(159-167) DNA(3024..3050)	Pol Epitope Map
Author Location	RT( C-96BW15C05)
Epitope	IFQSSMTKI	Epitope Alignment
Epitope Name	E
Subtype	C
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	DNA, alphavirus replicon
Vaccine strain	C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component	Gag, Gag-Pol, Pol

Notes

• HIV clade C gag, pol and fusion gagpol vaccines were compared in mice. Breadth of T cell responses was improved in mice immunized with gagpol fusion genes, compared to single antigen constructs. 5 new murine CD8+ T cell epitopes were mapped.
• This is a novel epitope.

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.

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