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Displaying record number 54865

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag(263-272 B27)
Epitope	KRWIILGLNK	Epitope Alignment
		Show epitope variants
Epitope Name	KK10 (263-272)
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	review, immunodominance, escape, dendritic cells, mutation acquisition, viral fitness and reversion, compensatory mutation

Notes

• This commentary summarizes work by Lichterfeld et al. [ JEM Vol. 204: 2785-7 (2007)]. HLA-B27 restricted CTLs presented with epitope KK10 (KRWIILGLNK) are known to keep infection at bay in LTPs. However, a triple mutation resulting in viral escape can occur after several years. The mutations are L268M, R264K(T/G) and S173A. L268M occurs early in infection and becomes fixed when bound to HLA-B27, conferring unknown viral advantage that is suggested to be due to its 3-fold higher affinity for ILT4. This may result in impaired DC and monocyte function. It is thought that the triple mutations compensate for each other, stabilizing them.

References

McMichael2007 Andrew J McMichael. Triple Bypass: Complicated Paths to HIV Escape. J. Exp. Med., 204(12):2785-2758, 26 Nov 2007. PubMed ID: 18025124. Show all entries for this paper.