Search CTL/CD8+ T-Cell Epitope Database

Found 20 matching records:

Displaying record number 58261

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HXB2 Location	gp160(37-45) gp120(37-45) DNA(6333..6359)	gp160 Epitope Map
Author Location	Env
Epitope	`TVYYGIPVW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope TVYYGIPVW stimulated peak EliSpot response in 4 subjects, and stimulated peak proliferation response in 3 subjects all of whom had not disease end point.

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.

Displaying record number 58264

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HXB2 Location	gp160(37-45) gp120(37-45) DNA(6333..6359)	gp160 Epitope Map
Author Location	Env
Epitope	`TVYYGVPMW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope TVYYGVPMW stimulated peak EliSpot response in 2 subjects, and stimulated peak proliferation response in no subjects. 1 subject each had reached and had not reached disease end point.

References

Displaying record number 58263

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HXB2 Location	gp160(37-45) gp120(37-45) DNA(6333..6359)	gp160 Epitope Map
Author Location	Env
Epitope	`TVYYGVPVW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope TVYYGVPVW stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in 5 subjects of whom 4 had and 1 had not reached disease end point.

References

Displaying record number 58251

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HXB2 Location	gp160(44-53) gp120(44-53) DNA(6354..6383)	gp160 Epitope Map
Author Location	Env
Epitope	`VWKDAETTLF`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope VWKDAETTLF stimulated peak EliSpot response in 2 subjects, but did not stimulate any peak proliferation response. One of the subjects had peak proliferative response to VWKDAKTTLF, and neither subject had reached disease end point.

References

Displaying record number 58271

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HXB2 Location	gp160(44-53) gp120(44-53) DNA(6354..6383)	gp160 Epitope Map
Author Location	Env
Epitope	`VWKDAKTTLF`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope VWKDAKTTLF stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in 2 subjects none of whom had reached disease end point.

References

Displaying record number 58270

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HXB2 Location	gp160(44-53) gp120(44-53) DNA(6354..6383)	gp160 Epitope Map
Author Location	Env
Epitope	`VWKDAKTTLF`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope VWKDAKTTLF stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in 2 subjects none of whom had reached disease end point.

References

Displaying record number 58276

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HXB2 Location	gp160(298-306) gp120(298-306) DNA(7116..7142)	gp160 Epitope Map
Author Location	Env
Epitope	`RPYNNTRKS`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RPYNNTRKS stimulated peak EliSpot response in no subjects, but did stimulate peak proliferation response in 1 subject who did not reach disease end point.

References

Displaying record number 58272

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HXB2 Location	gp160(298-306) gp120(298-306) DNA(7116..7142)	gp160 Epitope Map
Author Location	Env
Epitope	`RPYNNTRQS`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RPYNNTRQS stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in 2 subjects one of whom had reached disease end point.

References

Displaying record number 58273

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HXB2 Location	gp160(298-306) gp120(298-306) DNA(7116..7142)	gp160 Epitope Map
Author Location	Env
Epitope	`RPYNNTRRS`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RPYNNTRQS stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in 2 subjects one of whom had reached disease end point.

References

Displaying record number 58258

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`RAIEAQQQM`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIEAQQQM stimulated peak EliSpot response in no subject, and stimulated peak proliferation response in 1 subject. The subject with peak proliferative response had not reached disease end point.

References

Displaying record number 58256

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`RAIEAQQHM`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIEAQQHM stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in 1 other subject. The subject with peak EliSpot response had peak proliferative response to RAIEAQQQM and had not reached disease end point.

References

Displaying record number 58255

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`RAIETQQHL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIETQQHL stimulated peak EliSpot response in 1 subject, but did not stimulate any peak proliferation response. The subject had peak proliferative response to RAIEVQQHL, and had not reached disease end point.

References

Displaying record number 58253

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`RAIEAQQHL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIEAQQHL stimulated peak EliSpot response in 2 subjects, but did not stimulate any peak proliferation response. One of the subjects had peak proliferative response to KAIEAQQHM, and neither subject had reached disease end point.

References

Displaying record number 58260

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`RAIEVQQHL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIEVQQHL stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in one subject who had not disease end point.

References

Displaying record number 58259

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`KAIEAQQHM`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIEAQQHM stimulated peak EliSpot response in no subject, but stimulated peak proliferation response in 1 subject who had not reached disease end point.

References

Displaying record number 58265

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HXB2 Location	gp160(584-592) gp41(73-81) DNA(7974..8000)	gp160 Epitope Map
Author Location	Env
Epitope	`ERYLKDQQL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope ERYLKDQQL stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in . 2 of the subjects had peak proliferative response to ERYLKDQQL, and one of the subjects had reached disease end point.

References

Displaying record number 58195

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HXB2 Location	gp160(749-757) gp41(238-246) DNA(8469..8495)	gp160 Epitope Map
Author Location	Env
Epitope	`VTGFLALAW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope VTGFLALAW stimulated peak EliSpot response in 2 subjects, but did not stimulate any peak proliferation response. Both subjects reached disease end point.

References

Displaying record number 58266

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	`IPRRIRQGF`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope IPRRIRQGF stimulated peak EliSpot response in 3 subjects, and did not stimulate peak proliferation response in any subjects. Subjects with peak EliSpot to this epitope had peak proliferative responses to TVYYGVPVW, RPYNNTRQS and IPRRIRQGA. None of the subjects had reached disease end point.

References

Displaying record number 58267

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	`IPRRIRQGL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope IPRRIRQGL stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in none. That subject, whose peak proliferation was to VWKDAKTTLF, had not reached disease end point.

References

Displaying record number 58269

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	`IPRRIRQGA`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope IPRRIRQGA stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in 3 subjects. None of those subjects had reached disease end point.