Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55113

HXB2 Location	Gag(197-205) p24(65-73) DNA(1378..1404)	Gag Epitope Map
Author Location	Gag
Epitope	`AMQMLKETI`	Epitope Alignment
Subtype	A, B
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Country	Finland
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	vaccine antigen design

Vaccine Details

Vaccine type	DNA
Vaccine strain	A clade, B clade
Vaccine component	Env, Gag

Notes

A novel mouse model was used to test the efficacy of 2 HIV DNA vaccines in protection against tumor challenge. Comparable immunogenicity between the single and multi-clade vaccines tested was seen in different mouse strains. CTL response to HIV-1-APCs was both in vivo and in vitro and this animal model not only evaluated vaccine immunogenicity but also confirmed the potency of GTU-multi-HIV vaccines.

References

Malm2007 Maria Malm, Rein Sikut, Kai Krohn, and Vesna Blazevic. GTU-MultiHIV DNA Vaccine Results in Protection in a Novel P815 Tumor Challenge Model. Vaccine, 25(17):3293-301, 30 Apr 2007. PubMed ID: 17289222. Show all entries for this paper.

Displaying record number 55110

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	Env
Epitope	`RGPGRAFVTI`	Epitope Alignment
Subtype	A, B
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Country	Finland
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	vaccine antigen design

Vaccine Details

Vaccine type	DNA
Vaccine strain	A clade, B clade
Vaccine component	Env, Gag

Notes

A novel mouse model was used to test the efficacy of 2 HIV DNA vaccines in protection against tumor challenge. Comparable immunogenicity between the single and multi-clade vaccines tested was seen in different mouse strains. CTL response to HIV-1-APCs was both in vivo and in vitro and this animal model was safe and not only evaluated vaccine immunogenicity but also confirmed the potency of GTU-multi-HIV vaccines.