Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 62488

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HXB2 Location	Gag(36-44) p17(36-44) DNA(895..921)	Gag Epitope Map
Author Location	Gag(36-44)
Epitope	WASRELEKF	Epitope Alignment
		Show epitope variants
Epitope Name	WF936-44
Species (MHC/HLA)	human(B*35)
Immunogen	HIV-1 infection
Patient MHC/HLA	CH131: A*23:01, A*29:01, B*15:03, B*45:01, C*02:02, C*06:02
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	dynamics, mutation acquisition, viral replication

Notes

• Some mutations under study in patient CH0131 (4 Gag and 1 Pol) were found to have strong selection pressure despite not being adaptive-immunologically responsive. Alternate, host-driven selection-pressures, are postulated by the authors to drive this selection.
• Gag epitope, WASRELEKF, contains the K43R mutation that first appeared at day 91 post-screening and was fixed in CH0131 by day 273.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.

Displaying record number 62490

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HXB2 Location	Gag(156-165) p24(24-33) DNA(1255..1284)	Gag Epitope Map
Author Location	Gag(156-164)
Epitope	VKVIEEKAF{S}	Epitope Alignment
		Show epitope variants
Epitope Name	VF9156-164
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	CH131: A*23:01, A*29:01, B*15:03, B*45:01, C*02:02, C*06:02
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	dynamics, mutation acquisition

Notes

• Some mutations under study in patient CH0131 (4 Gag and 1 Pol) were found to have strong selection pressure despite not being adaptive-immunologically responsive. Alternate, host-driven selection-pressures, are postulated by the authors to drive this selection.
• Gag epitope, VKVIEEKAF, contains the E161Q/S165N mutations that were fixed to 100% in CH0131 by day 670.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.

Displaying record number 62492

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag(240-249)
Epitope	TSNLQEQIGW	Epitope Alignment
		Show epitope variants
Epitope Name	TW10 240-249
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Patient MHC/HLA	CH131: A*23:01, A*29:01, B*15:03, B*45:01, C*02:02, C*06:02
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	dynamics, mutation acquisition, viral replication

Notes

• Some mutations under study in patient CH0131 (4 Gag and 1 Pol) were found to have strong selection pressure despite not being adaptive-immunologically responsive. Alternate, host-driven selection-pressures, are postulated by the authors to drive this selection.
• Gag epitope, TSNLQEQIGW, contains the N242T mutations that were fixed to 100% in CH0131 by day 670.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.

Displaying record number 62489

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HXB2 Location	Gag(321-329) p24(189-197) DNA(1750..1776)	Gag Epitope Map
Author Location	Gag(319-327)
Epitope	LLIQNANPD	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	CH131: A*23:01, A*29:01, B*15:03, B*45:01, C*02:02, C*06:02
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	dynamics, mutation acquisition, viral replication

Notes

• Some mutations under study in patient CH0131 (4 Gag and 1 Pol) were found to have strong selection pressure despite not being adaptive-immunologically responsive. Alternate, host-driven selection-pressures, are postulated by the authors to drive this selection.
• Gag epitope, LLIQNANPD, contains the synonymous N323tc mutation that first appeared at day 175 post-screening and was fixed to 100% in CH0131 by day 670.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.

Displaying record number 62491

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HXB2 Location	Pol(977-986) Integrase(262-271) DNA(5013..5042)	Pol Epitope Map
Author Location	Pol(978-986)
Epitope	RRKAKIIRDY	Epitope Alignment
Epitope Name	RY10 978-986
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	CH131: A*23:01, A*29:01, B*15:03, B*45:01, C*02:02, C*06:02
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	dynamics, mutation acquisition

Notes

• Some mutations under study in patient CH0131 (4 Gag and 1 Pol) were found to have strong selection pressure despite not being adaptive-immunologically responsive. Alternate, host-driven selection-pressures, are postulated by the authors to drive this selection.
• Pol epitope RRKAKIIRDY contains the A980V mutation that was fixed to 100% in CH0131 by day 670.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.