Search CTL/CD8+ T-Cell Epitope Database

Found 12 matching records:

Displaying record number 61243

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HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	Gag(20-29)
Epitope	`RLRPGGKKKY`	Epitope Alignment
Epitope Name	RY10
Species (MHC/HLA)	human(A*03:01)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Epitope RY10, RLRPGGKKKY-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression.

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.

Displaying record number 61244

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	Gag(77-85)
Epitope	`SLYNTVATL`	Epitope Alignment
Epitope Name	SL9
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Immunodominant epitope SL9, SLYNTVATL-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression. High affinity variants of a natural TCR specific for SL9-A*0201 generated even higher levels of sensitivity and polyfunctionality [Varela-Rohena2008].

References

Displaying record number 61240

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Epitope Name	KF11
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. KAFSPEVIPMF (KF11)-TCR repertoire are diverse and flexible and TCR gene usage is biased.

References

Displaying record number 61228

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	Gag
Epitope	`TPQDLNTML`	Epitope Alignment
Epitope Name	TL9
Subtype	C
Species (MHC/HLA)	human(B42, B81)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Subtype A Gag-TL9 speicific CTL are a distinct clonotype from Subtype C Gag-TL9 (TPQDLNTML)-specific oligoclonal CTL [Geldmacher2009].

References

Displaying record number 61229

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	Gag
Epitope	`TPQDLNMML`	Epitope Alignment
Epitope Name	TL9
Subtype	A
Species (MHC/HLA)	human(B42, B81)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Subtype C Gag-TL9 speicific CTL are a distinct clonotype from Subtype A Gag-TL9 (TPQDLNMML)-specific almost-monoclonal or oligoclonal CTL [Geldmacher2009].

References

Displaying record number 61242

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HXB2 Location	Gag(254-262) p24(122-130) DNA(1549..1575)	Gag Epitope Map
Author Location	Gag(254-262)
Epitope	`NPVPVGNIY`	Epitope Alignment
Epitope Name	NY9
Species (MHC/HLA)	human(B*35:01)
Immunogen	HIV-2 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Epitope NY9, NPVPVGNIY-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression, as highly avid oligoclonal CTL are observed in subjects with slow progression to disease.

References

Displaying record number 61237

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag(263-272)
Epitope	`KRWIILGLNK`	Epitope Alignment
		Show epitope variants
Epitope Name	KK10
Species (MHC/HLA)	human(B*27:05)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Immunodominant epitope KK10, KRWIILGLNK-clonotypic CTL populations evolve over time. KK10-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression. KK10-A*2705 CTL are seen to suppress viral replication by cross reactivity to dominant mutants like the L268M escape.

References

Displaying record number 61238

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	Pol
Epitope	`TAFTIPSI`	Epitope Alignment
		Show epitope variants
Epitope Name	TI8
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Immunodominant TAFTIPSI(TI8)-specific CTL are crossreactive to the I290V escape and vice versa. Clonotypes with higher affinity for wild type TI8 than the TV mutant (TAFTIPSv) are thought to drive mutant TV-virus selection while those with equal crossreactivity are seen upon emergence of the TV mutants. Despite its effectiveness, TI8-B*5101 are shown to have low affinity interaction.

References

Displaying record number 61241

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(263-272)
Epitope	`QVPLRPMTYK`	Epitope Alignment
Epitope Name	QK10
Species (MHC/HLA)	human(A*03:01)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Epitope QK10, QVPLRPMTYK-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression.

References

Displaying record number 61239

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HXB2 Location	Nef(90-97) DNA(9064..9087)	Nef Epitope Map
Author Location	Nef
Epitope	`FLKEKGGL`	Epitope Alignment
Epitope Name	FL8
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. FLKEKGGL (FL8)-TCR repertoire are diverse and flexible and TCR gene usage is biased.

References

Displaying record number 61235

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HXB2 Location	Nef(134-141) DNA(9196..9219)	Nef Epitope Map
Author Location	Nef
Epitope	`RYPLTFGW`	Epitope Alignment
		Show epitope variants
Epitope Name	RW8
Species (MHC/HLA)	human(A*24:02)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Epitope RW8, RYPLTFGW, is superimposed within RF10, RYPLTFGWCF, and both drive distinct HIV-specific CTL repertoires exhibiting different properties. RW8-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression.

References

Displaying record number 61236

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HXB2 Location	Nef(134-143) DNA(9196..9225)	Nef Epitope Map
Author Location	Nef
Epitope	`RYPLTFGWCF`	Epitope Alignment
		Show epitope variants
Epitope Name	RF10
Species (MHC/HLA)	human(A*24:02)
Immunogen	HIV-1 infection
Experimental methods	Other
Keywords	review, immunodominance, TCR usage, variant cross-reactivity

Notes

Recent findings of the HIV-specific TCR repertoire are reviewed here. Epitope RF10, RYPLTFGWCF, superimposes within itself, RYPLTFGW, and both drive distinct HIV-specific CTL repertoires exhibiting different properties. RF10-CTL avidity correlates with ability of infected individuals to respond to antigen with sensitivity, polyfunctionality and viral suppression.