Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 53048

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	RT(313-321)
Epitope	AIFQSSMTK	Epitope Alignment
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*11:01)
Immunogen
Country	Thailand
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), structure

Notes

• HLA-A*1101 has been associated with resistance to acquisition of HIV-1 infection in female sex-workers in Thailand. Its crystal structure has been determined in association with two immunodominant A*1101 HIV-1 CTL epitopes. Its anchor residues are confirmed as P2(Ile/Val) and C-term (Lys). The backbone conformation of the peptides is defined as two bulges separated by a secondary anchor residue (P6 Ser or Met) that may offer various advantages in the selection and presentation of CTL epitopes by HLA-A*1101.

References

Li2004 Lenong Li and Marlene Bouvier. Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. J. Immunol., 172(10):6175-6184, 15 May 2004. PubMed ID: 15128805. Show all entries for this paper.

Displaying record number 53049

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(73-82)
Epitope	QVPLRPMTYK	Epitope Alignment
Subtype	B, CRF01_AE
Species (MHC/HLA)	(A*11:01)
Immunogen
Country	Thailand
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), immunodominance, structure

Notes

• HLA-A*1101 has been associated with resistance to acquisition of HIV-1 infection in female sex-workers in Thailand. Its crystal structure has been determined in association with two immunodominant A*1101 HIV-1 CTL epitopes. Its anchor residues are confirmed as P2(Ile/Val) and C-term (Lys). The backbone conformation of the peptides is defined as two bulges separated by a secondary anchor residue (P6 Ser or Met) that may offer various advantages in the selection and presentation of CTL epitopes by HLA-A*1101.

References

Li2004 Lenong Li and Marlene Bouvier. Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. J. Immunol., 172(10):6175-6184, 15 May 2004. PubMed ID: 15128805. Show all entries for this paper.