Search CTL/CD8+ T-Cell Epitope Database

Found 12 matching records:

Displaying record number 53763

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HXB2 Location	Gag(267-274) p24(135-142) DNA(1588..1611)	Gag Epitope Map
Author Location	Gag(267-274 HXB2)
Epitope	ILGLNKIV	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02, A*03)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• ILGLNKIV is the epitope in the HXB2 reference strain sequence, and is also the most common form in CRF01.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53764

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HXB2 Location	Gag(269-277) p24(137-145) DNA(1594..1620)	Gag Epitope Map
Author Location	Gag(269-277 HXB2)
Epitope	GLNKVRMY	Epitope Alignment
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(B*62)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• GLNKVRMY is the epitope in the HXB2 reference strain sequence, and is also the most common form in CRF01.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53765

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HXB2 Location	Gag(275-283) p24(143-151) DNA(1612..1638)	Gag Epitope Map
Author Location	Gag(275-283 HXB2)
Epitope	RMYSPTSIL	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• The most common CRF01_AE variant RMYSPvSIL had a higher HLA-binding score than the HXB2 epitope. The rare variant, rmyspVsiW was predicted not to bind to A*02.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53767

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HXB2 Location	Nef(83-90) DNA(9043..9066)	Nef Epitope Map
Author Location	Nef(83-90 HXB2)
Epitope	AAVDLSHF	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(B*62)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE variant gAfDLSfF had a higher HLA-B*62 binding score than the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53766

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HXB2 Location	Nef(83-91) DNA(9043..9069)	Nef Epitope Map
Author Location	Nef(83-91 HXB2)
Epitope	AAVDLSHFL	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• The CRF01_AE variant gAfDLSfFL had a higher HLA-A*02 binding score than the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53768

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HXB2 Location	Nef(86-94) DNA(9052..9078)	Nef Epitope Map
Author Location	Nef(86-94 HXB2)
Epitope	DLSHFLKEK	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*03, A*11)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• The CRF01_AE variant DLSfFLKEK had same HLA-binding score as the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53769

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HXB2 Location	Nef(121-128) DNA(9157..9180)	Nef Epitope Map
Author Location	Nef(121-128 HXB2)
Epitope	FPDWQNYT	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*01)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE has 2 forms, FPDWQNYT, like the HXB2 form, and FPDWhNYT. Both are predicted to bind to A*01.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53770

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HXB2 Location	Nef(134-143) DNA(9196..9225)	Nef Epitope Map
Author Location	Nef(134-143 HXB2)
Epitope	RYPLTFGWCY	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*24)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE variant RYPLcFGWCY had same HLA-binding score as the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53771

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HXB2 Location	Nef(136-145) DNA(9202..9231)	Nef Epitope Map
Author Location	Nef(136-145 HXB2)
Epitope	PLTFGWCYKL	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE variant PLcFGWCfKL had a higher HLA-binding score than the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53772

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189 HXB2)
Epitope	VLEWRFDSRL	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE variant LmWkFDSaL had a higher HLA-binding score than the HXB2 epitope, which isn't predicted to bind to A*02.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53773

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HXB2 Location	Nef(184-191) DNA(9346..9369)	Nef Epitope Map
Author Location	Nef(184-191 HXB2)
Epitope	RFDSRLAF	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*01)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• CRF01_AE common variant kFDSaLAr had same HLA-binding score as the HXB2 epitope.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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Displaying record number 53774

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HXB2 Location	Nef(190-198) DNA(9364..9390)	Nef Epitope Map
Author Location	Nef(190-198 HXB2)
Epitope	AFHHVAREL	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*24)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

• The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
• ArrHiAREL, ArtHiAREL, and ArkHiAREL variants are the three forms found in CRF01, and none are predicted to bind to A*024.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

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