Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 53046

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160
Epitope	`RGPGRAFVTI`	Epitope Alignment
Epitope Name	P18-I10
Subtype	B
Species (MHC/HLA)	mouse
Immunogen	vaccine
Experimental methods	Chromium-release assay
Keywords	genital and mucosal immunity

Vaccine Details

Vaccine type	vaccinia with H1 influenza HA gene cassette
Vaccine strain	B clade IIIB
Vaccine component	gp160

Notes

The intraepithelial compartment of the intestinal mucosa is shown to be a major site for preventing virus spread by thymus-derived CD8alphaß-positive Ag specific CTLs and CD8alpha,alpha+gamma,delta cells, which regulate virus spread in a P18-I10 vaccinia vector mouse infection model.

References

Kuribayashi2004 Hideki Kuribayashi, Ayako Wakabayashi, Masumi Shimizu, Hiroshi Kaneko, Yoshihiko Norose, Yohko Nakagawa, Jian Wang, Yoshihiro Kumagai, David H. Margulies, and Hidemi Takahashi. Resistance to Viral Infection by Intraepithelial Lymphocytes in HIV-1 P18-I10-Specific T-Cell Receptor Transgenic Mice. Biochem. Biophys. Res. Commun., 316(2):356-363, 2 Apr 2004. PubMed ID: 15020225. Show all entries for this paper.