Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 81

HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17(77-85)
Epitope	SLYNTVATL	Epitope Alignment
Epitope Name	SL9
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dendritic cells

Notes

• Allogeneic dendritic cells (DCs) were obtained from HLA-identical siblings, pulsed with rgp160 MN or A2-restricted HIV-1 epitope peptides, and infused monthly into six HIV-infected patients.
• 1/6 showed increased env-specific CTL and increased lymphoproliferative responses, 2/6 showed increase only in proliferative responses, and 3/6 showed no change -- pulsed DCs were well tolerated.
• SLYNTVATL is a conserved HLA-A2 epitope included in this study -- 3/6 patients had this sequence as their HIV direct sequence, one had the form SLYNTVAVL and all four of these had a detectable CTL response -- the other two had either the sequence SLFSAVAVL or SLFSAVAAL and no detectable CTL response.

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.

Displaying record number 424

HXB2 Location	Pol(263-273) RT(108-118) DNA(2871..2903)	Pol Epitope Map
Author Location	RT(267-277)
Epitope	VLDVGDAYFSV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dendritic cells

Notes

• Allogeneic dendritic cells (DCs) were obtained from HLA-identical siblings, pulsed with rgp160 MN or A2-restricted HIV-1 epitope peptides, and infused monthly into six HIV-infected patients.
• 1/6 showed increased env-specific CTL and increased lymphoproliferative responses, 2/6 showed increase only in proliferative responses, and 3/6 showed no change -- pulsed DCs were well tolerated.
• VLDVGDAYFSV is a conserved HLA-A2 epitope included in this study -- 4/6 patients had this sequence as their HIV direct sequence, but only one of these had a detectable CTL response -- the other two had the sequences EEDVGDAYFSV and ELDVGDAYFSV and no detectable CTL response.

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.

Displaying record number 514

HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT(464-472)
Epitope	ILKEPVHGV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dendritic cells

Notes

• Allogeneic dendritic cells (DCs) were obtained from HLA-identical siblings, pulsed with rgp160 MN or A2-restricted HIV-1 epitope peptides, and infused monthly into six HIV-infected patients.
• 1/6 showed increased env-specific CTL and increased lymphoproliferative responses, 2/6 showed increase only in proliferative responses, and 3/6 showed no change -- pulsed DCs were well tolerated.
• ILKEPVHGV is a conserved HLA-A2 epitope included in this study -- 5/6 patients had this sequence as their HIV direct sequence, and these had a detectable CTL response-- one person carried the form ILREPVHGV and had no detectable CTL.

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.

Displaying record number 583

HXB2 Location	Pol(956-964) Integrase(241-249) DNA(4950..4976)	Pol Epitope Map
Author Location	Pol(956-964)
Epitope	LLWKGEGAV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dendritic cells

Notes

• Allogeneic dendritic cells (DCs) were obtained from HLA-identical siblings, pulsed with rgp160 MN or A2-restricted HIV-1 epitope peptides, and infused monthly into six HIV-infected patients.
• 1/6 showed increased Env-specific CTL and increased lymphoproliferative responses, 2/6 showed increase only in proliferative responses, and 3/6 showed no change -- pulsed DCs were well tolerated.
• LLWKGEGAV is a conserved HLA-A2 epitope included in this study -- 6/6 patients had this sequence as their HIV direct sequence, but only four of these had a detectable CTL response.

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.

Displaying record number 667

HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	gp120(120-128)
Epitope	KLTPLCVTL	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dendritic cells

Notes

• Allogeneic dendritic cells (DCs) were obtained from HLA-identical siblings, pulsed with rgp160 MN or A2-restricted HIV-1 epitope peptides, and infused monthly into six HIV-infected patients.
• 1/6 showed increased env-specific CTL and increased lymphoproliferative responses, 2/6 showed increase only in proliferative responses, and 3/6 showed no change -- pulsed DCs were well tolerated.
• KLTPLCVTL is a conserved HLA-A2 epitope included in this study -- all six patients had this sequence as their HIV direct sequence, and a detectable CTL response.
• CTL demonstrated against peptide-coated target, epitope is naturally processed and enhancible with vaccine.

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.

Displaying record number 876

HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41(814-823)
Epitope	SLLNATDIAV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	dendritic cells

Notes

• Allogeneic dendritic cells (DCs) were obtained from HLA-identical siblings, pulsed with rgp160 MN or A2-restricted HIV-1 epitope peptides, and infused monthly into six HIV-infected patients.
• 1/6 showed increased env-specific CTL and increased lymphoproliferative responses, 2/6 showed increase only in proliferative responses, and 3/6 showed no change -- pulsed DCs were well tolerated.
• SLLNATDIAV is a conserved HLA-A2 epitope included in this study -- 4/6 patients had this sequence as their HIV direct sequence, and 3 of these had a detectable CTL response -- the other two had either the sequence SLFNAIDIAV or SLLNTTDIVV and no detectable CTL response.
• CTL demonstrated against peptide-coated target, epitope is naturally processed and enhancible with vaccine.

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.