Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 1216

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HXB2 Location	gp160(103-111) gp120(103-111) DNA(6531..6557)	gp160 Epitope Map
Author Location	Env(102-110)
Epitope	QMHEDIISL	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, TCR usage

Notes

• CTL responses in six patients to four Env epitopes were studied: D2: LLNATAIAV, 5.3: RLRDLLLIV, D1: KLTPLCVTL, and 4.3: QMHEDIISL -- all have A2 anchor residues.
• The C terminal epitopes (D2 and 5.3) were highly variable and the variability was considered responsible for limited CTL response, while D1 and 4.3, N-terminal epitopes, were much more conserved and gave evidence of high levels of CTL response in vitro.
• Peptides 4.3 and D1 bound HLA-A*0201 molecules with high affinity.
• Peptides 4.3 and D1 stimulated CTL with a relatively limited TCR Vβ repertoire.

References

Kmieciak1998b D. Kmieciak, I. Bednarek, M. Takiguchi, T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, H. Teppler, J. Pientka, S. H. Hsu, Y. Kaneko, and D. Kozbor. The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein. Int. Immunol., 10:1789-1799, 1998. PubMed ID: 9885899. Show all entries for this paper.

Displaying record number 1217

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HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	Env(120-128)
Epitope	KLTPLCVTL	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, TCR usage

Notes

• CTL responses in six patients to four Env epitopes were studied: D2: LLNATAIAV, 5.3: RLRDLLLIV, D1: KLTPLCVTL, and 4.3: QMHEDIISL---all have A2 anchor residues.
• The C terminal epitopes (D2 and 5.3) were highly variable and the variability was considered responsible for limited CTL response, while D1 and 4.3, N-terminal epitopes, were much more conserved and gave evidence of high levels of CTL response in vitro.
• Peptides 4.3 and D1 bound HLA-A*0201 molecules with high affinity.
• Peptides 4.3 and D1 stimulated CTL with a relatively limited TCR Vβ repertoire.
• In a longitudinal study, the CTL response to the variable D2 epitope diminished over time, while the response to the conserved epitope D1 stayed higher over time.

References

Kmieciak1998b D. Kmieciak, I. Bednarek, M. Takiguchi, T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, H. Teppler, J. Pientka, S. H. Hsu, Y. Kaneko, and D. Kozbor. The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein. Int. Immunol., 10:1789-1799, 1998. PubMed ID: 9885899. Show all entries for this paper.

Displaying record number 1218

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HXB2 Location	gp160(770-778) gp41(259-267) DNA(8532..8558)	gp160 Epitope Map
Author Location	Env(679-777)
Epitope	RLRDLLLIV	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity

Notes

• CTL responses in six patients to four Env epitopes were studied: D2: LLNATAIAV, 5.3: RLRDLLLIV, D1: KLTPLCVTL, and 4.3: QMHEDIISL -- all have A2 anchor residues.
• The C terminal epitopes (D2 and 5.3) were highly variable and the variability was considered responsible for limited CTL response, while D1 and 4.3, N-terminal epitopes, were much more conserved and gave evidence of high levels of CTL response in vitro.
• Peptides 5.3 and D2 bound to HLA A*0201 with low affinity.

References

Kmieciak1998b D. Kmieciak, I. Bednarek, M. Takiguchi, T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, H. Teppler, J. Pientka, S. H. Hsu, Y. Kaneko, and D. Kozbor. The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein. Int. Immunol., 10:1789-1799, 1998. PubMed ID: 9885899. Show all entries for this paper.

Displaying record number 1219

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HXB2 Location	gp160(814-822) gp41(303-311) DNA(8664..8690)	gp160 Epitope Map
Author Location	Env(815-823)
Epitope	LLNATAIAV	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity

Notes

• CTL responses in six patients to four Env epitopes were studied: D2: LLNATAIAV, 5.3: RLRDLLLIV, D1: KLTPLCVTL, and 4.3: QMHEDIISL---all have A2 anchor residues.
• The C terminal epitopes (D2 and 5.3) were highly variable and the variability was considered responsible for limited CTL response, while D1 and 4.3, N-terminal epitopes, were much more conserved and gave evidence of high levels of CTL response in vitro.
• Peptides 5.3 and D2 bound to HLA A*0201 with low affinity and were variable, particularly D2.
• Substitutions in peptide D2: llnTIaiav did not abrogate the response, but diminished it.
• In a longitudinal study, the CTL response to the variable D2 epitope diminished over time, while the response to the conserved epitope D1 stayed higher.

References

Kmieciak1998b D. Kmieciak, I. Bednarek, M. Takiguchi, T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, H. Teppler, J. Pientka, S. H. Hsu, Y. Kaneko, and D. Kozbor. The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein. Int. Immunol., 10:1789-1799, 1998. PubMed ID: 9885899. Show all entries for this paper.